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| 1 | Obstructive jaundice due to hepatobiliary cystadenoma or cystadenocarcinoma显示文摘Hepatobiliary cystadenomas (HBC) and cystadenocarci- nomas are rare cystic lesions. Most patients with these lesions are asymptomatic, but presentation with ob- structive jaundice may occur. The first patient presented with intermittent colicky pain and recurrent obstructive jaundice. Imaging studies revealed a polypoid lesion in the left hepatic duct. The second patient had recurrent jaundice and cholangitis. Endoscopic retrograde cholan- giopancreatography (ERCP) showed a cystic lesion at the confluence of the hepatic duct. In the third patient with intermittent jaundice and cholangitis, cholangioscopy re- vealed a papillomatous structure protruding into the left bile duct system. In the fourth patient with obstructive jaundice, CT-scan showed slight dilatation of the intrahe- patic bile ducts and dilatation of the common bile duct of 3 cm. ERCP showed filling of a cystic lesion. All patients underwent partial liver resection, revealing HBC in the specimen. In the fifth patient presenting with obstructive jaundice, ultrasound examination showed a hyperecho- genic cystic lesion centrally in the liver. The resection specimen revealed a hepatobiliary cystadenocarcinoma. HBC and cystadenocarcinoma may give rise to obstruc- tive jaundice. Evaluation with cross-sectional imaging techniques is useful. ERCP is a useful tool to differentiate extraductal from intraductal obstruction. | Deha Erdogan Olivier RC Busch Erik AJ Rauws Otto M van Delden Dirk J Gouma Thomas M van Gulik | 2006 | World Journal of Gastroenterology2006，12，35： | 26 |
| 2 | Results of percutaneous sclerotherapy and surgical treatment in patients with symptomatic simple liver cysts and polycystic liver disease显示文摘AIM: To evaluate the results of the treatment of simple liver cysts (solitary and multiple) and polycystic liver disease (PLD) using percutaneous sclerotherapy and/or surgical procedures in a single tertiary referral centre. METHODS: Retrospective analysis of 54 patients referred for evaluation and possible treatment of simple liver cysts (solitary and multiple) and PLD, from January 1997 to July 2006. RESULTS: Simple liver cysts were treated in 41 pts (76/) with a mean size of 12.6 cm. The most common reason for referral was abdominal pain or discomfort (85/). Percutaneous sclerotherapy was performed as initial treatment in 30 pts, showing cyst recurrence in 6 pts (20/). Surgical treatment was initially performed in 11 pts with cyst recurrence in 3 pts (27/). PLD was treated in 13 pts (24/) with a mean size of the dominant cyst of 13 cm. Percutaneous sclerotherapy for PLD was performed in 9 pts with recurrence in 7 pts (77.8/). Surgical treatment for PLD was undertaken in 4 pts (30.8/) with recurrence in all. Eventually, 2 pts with PLD in the presence of polycystic kidney disease underwent liver-and kidney transplantation because of deterioration of liver and kidney function. CONCLUSION: The majority of patients with simple liver cysts and PLD are referred for progressive abdominal pain. As initial treatment, percutaneous sclerotherapy is appropriate. Surgical deroofing is indicated in caseof cyst recurrence after percutaneous sclerotherapy. However, the results of percutaneous sclerotherapy and surgical treatment for PLD are disappointing. Partial liver resection is indicated when there is suspicion of a pre-malignant lesion. | Deha Erdogan Otto M van Delden Erik AJ Rauws Olivier RC Busch Johan S Lameris Dirk J Gouma Thomas M van Gulik | 2007 | World Journal of Gastroenterology2007，13，22： | 15 |
| 3 | Endoscopic and Percutaneous Preoperative Biliary Drainage in Patients with Suspected Hilar Cholangiocarcinoma显示文摘 | Jaap J. Kloek Niels A. Gaag Yalda Aziz Erik A. J. Rauws Otto M. Delden Johan S. Lameris Olivier R. C. Busch Dirk J. Gouma Thomas M. Gulik | 2010 | Journal of Gastrointestinal Surgery2010，，1： | 3 |
| 4 | Percutaneous drainage and stenting for palliation of malignant bile duct obstruction显示文摘 | Otto M. Delden Johan S. Laméris | 2008 | European Radiology2008，，3： | 3 |
| 5 | Percutaneous drainage and stenting for palliation of malignant bile duct obstruction显示文摘 | Otto M. Delden Johan S. Laméris | 2008 | European Radiology2008，，3： | 3 |
| 6 | The synoptic setting of thunderstorms in western Europe显示文摘 | Aarnout van Delden | 2001 | Atmospheric Research2001，，1： | 2 |
| 7 | Effect of hepatic artery embolization on liver hypertrophy response in a rabbit liver VX2tumor model显示文摘BACKGROUND:Portal vein embolization not only induces hypertrophy of the non-embolized liver,but also enhances tumor growth.The latter could be prevented by embolizing the hepatic arteries supplying the tumor-bearing liver segments.This study aimed to determine the effects of transcatheter arterial embolization(TAE)on tumor volume and liver regeneration in a rabbit VX2 tumor model.METHODS:Twenty-three rabbits underwent subcapsular tumor implantation with a VX2 tumor.Two weeks after implantation,18 rabbits were used for TAE experiments,5were for sham controls.Tumor response and liver regeneration response of the embolized cranial and non-embolized caudal liver lobes were assessed by CT volumetry,liver to body weight index,and the amount of proliferating hepatocytes.RESULTS:All super-selective arterial tumor embolization procedures were performed successfully.Despite embolization,the tumor volume increased after an initial steady state.The tumor volume after embolization was smaller than that of the sham group,but this difference was not significant.Massive necrosis of the tumor,however,was seen after embolization,without damage of the surrounding liver parenchyma.There was a significant atrophy response of the tumor bearing cranial lobe after super-selective arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized,caudal lobe.This regeneration response was confirmed histologically by a significantly higher number of proliferating hepatocytes on the Ki-67 stained slides.CONCLUSIONS:Super-selective,bland arterial coil embolization causes massive necrosis of the tumor,despite increase of volume on CT scan.Atrophy of the tumor bearing liver lobe is seen after arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized lobe,despite absence of histological damage of the tumor-surrounding liver parenchyma. | Krijn P van Lienden Lisette T Hoekstra Jessica D van Trigt Joris J Roelofs Otto M van Delden Thomas M van Gulik | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 2 |
| 8 | Portal Vein Embolization Before Liver Resection: A Systematic Review显示文摘 | K. P. Lienden J. W. Esschert W. Graaf S. Bipat J. S. Lameris T. M. Gulik O. M. Delden | 2013 | CardioVascular and Interventional Radiology2013，，1： | 2 |
| 9 | Differentiation of malignant and benign proximal bile duct strictures: The diagnostic dilemma显示文摘AIM: To identify the criteria for the differentiation of hilar cholangiocarcinoma (HCCA) from benign strictures. METHODS: A total of 68 patients underwent resection of lesions suspicious for HCCA between 1998 and 2006. The results of laboratory investigations, imaging studies and brush cytology were collected. These fi ndings were analyzed to obtain the fi nal diagnosis. RESULTS: Histological examination of the resected specimens confirmed HCCA in 58 patients (85%, group Ⅰ) whereas 10 patients (15%, groupⅡ) were diagnosed to have benign strictures. The most common presenting symptom was obstructive jaundice in 77% patients (79% group Ⅰvs 60% group Ⅱ P = 0.23). Laboratory findings showed greater elevation of transaminase levels in group Ⅰcompared to group Ⅱ The various imaging modalities showed vascular involvement exclusively in the malignant group (36%,P < 0.05). Brush cytology was positive for malignant cells in only 50% patients in group Ⅰ whereas none in group Ⅱ showed malignant cells. CONCLUSION: Despite improvements in imaging techniques, 10 patients (15%) with a presumptive diagnosis of HCCA were ultimately found to have benign strictures. Except for vascular involvement which was associated significantly with malignancy, there were no conclusive features of malignancy on regular imaging modalities. This uncertainty should be taken into account when patients with a suspicious lesion at the liver hilum are considered for resection. | Jaap Jacob Kloek Otto Marinus van Delden Deha Erdogan Fibo Jan ten Kate Erik Anthoni Rauws Olivier Robert Busch Dirk Joan Gouma Thomas Mathijs van Gulik | 2008 | World Journal of Gastroenterology2008，14，32： | 2 |
| 10 | Selective Transcatheter Arterial Embolization for Treatment of Bleeding Complications or Reduction of Tumor Mass of Hepatocellular Adenomas显示文摘 | Deha Erdogan Otto M. Delden Olivier R. C. Busch Dirk J. Gouma Thomas M. Gulik | 2007 | CardioVascular and Interventional Radiology2007，，6： | 2 |
| 11 | Ultrasonography, computed tomography and magnetic resonance imaging for diagnosis and determining resectability of pancreatic adenocar cinoma: a meta-analysis 显示文摘 | Bipat S Phoa SS van Delden OM | 2005 | J Comput Assist Tomogr2005，29，4： | 1 |
| 12 | Management of liver hemangiomas according to size and symptoms 显示文摘 | Erdogan D Busch OR van Delden OM | 2007 | J Gastro- enterol Hepatol2007，22，11： | 1 |
| 13 | Endovascular thrombectomy and thrombolysis for severe cerebral sinus thrombosis:a prospective study显示文摘 | Stam J Majoie CB van Delden OM | | 0，，05： | 1 |
| 14 | Emifentanil-sevoflurane anaesthesia for laparoscopic cholecystectomy:comparison of three dose regimens显示文摘 | Van Delden PG Houweling PL Bencini AF | 2002 | Anesthesia2002，57，3： | 1 |
| 15 | Ultrasonography,computed tomography and magnedc resonance imaging for diagnosis and determining resectability of pancreatic adenocarcinoma:a meta-analysis显示文摘 | Bipat S Phoa SS Van Delden OM | 2005 | J Comput Assist Tomogr2005，29，4： | 1 |
| 16 | Endoscopic partial inferior turbinoplasty显示文摘 | DELDEN M R COOK P R DAVIS W E | 1999 | Otolaryngol Head Neck Surg1999，121，： | 1 |
| 17 | Management of liver hemangiomas according to size and Symptoms 显示文摘 | Erdogan D Busch OR van Delden OM | 2007 | J Gastroenterol Hepatol2007，22，11： | 1 |
| 18 | Remifentanil-sevoflurane anaesthesia for laparoscopic cholecystectomy:comparison of three dose regimens显示文摘 | Van Delden PG Houweling PL Bencini AF | 2002 | Anaesthesia2002，57，3： | 1 |
| 19 | In-hospital transfer is a risk factor for invasive filamentous fungal infection among hospitalized patients with hematological malignancies:a matched case-control study显示文摘 | Gayet-Ageron A Iten A Van Delden C | 2015 | Infect Control Hosp Epidemiol2015，36，3： | 1 |
| 20 | Ultrasonography, computed tomography and magnetic resonance imaging for diagnosis and determining resectability of pancreatic adenocarcinoma: a meta - analysis显示文摘 | Bipat S Phoa SS van Delden OM | 2005 | J Comput Assist Tomogr2005，29，4： | 1 |
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