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| 1 | Mitochondrial neuronal uncoupling proteins:a target for potential disease-modification in Parkinson’s disease Philip显示文摘This review gives a brief insight into the role of mitochondrial dysfunction and oxidative stress in the converging pathogenic processes involved in Parkinson’s disease(PD).Mitochondria provide cellular energy in the form of ATP via oxidative phosphorylation,but as an integral part of this process,superoxides and other reactive oxygen species are also produced.Excessive free radical production contributes to oxidative stress.Cells have evolved to handle such stress via various endogenous anti-oxidant proteins.One such family of proteins is the mitochondrial uncoupling proteins(UCPs),which are anion carriers located in the mitochondrial inner membrane.There are five known homologues(UCP1 to 5),of which UCP4 and 5 are predominantly expressed in neural cells.In a series of previous publications,we have shown how these neuronal UCPs respond to 1-methyl-4-phenylpyridinium(MPP+;toxic metabolite of MPTP)and dopamine-induced toxicity to alleviate neuronal cell death by preserving ATP levels and mitochondrial membrane potential,and reducing oxidative stress.We also showed how their expression can be influenced by nuclear factor kappa-B(NF-B)signaling pathway specifically in UCP4.Furthermore,we previously reported an interesting link between PD and metabolic processes through the protective effects of leptin(hormone produced by adipocytes)acting via UCP2 against MPP+-induced toxicity.There is increasing evidence that these endogenous neuronal UCPs can play a vital role to protect neurons against various pathogenic stresses including those associated with PD.Their expression,which can be induced,may well be a potential therapeutic target for various drugs to alleviate the harmful effects of pathogenic processes in PD and hence modify the progression of this disease. | WL Ho Jessica WM Ho Hui-Fang Liu Danny HF So Zero HM Tse Koon-Ho Chan David B Ramsden Shu-Leong Ho | 2012 | Translational Neurodegeneration2012，1，1： | 3 |
| 2 | Integron-mediated multidrug resistance in a global collection of nontyphoidal salmonella enterica isolates显示文摘 | Mary GK Jane WM David LP | 2009 | Emerg Infect Dis2009，15，3： | 1 |
| 3 | Wound bed preparation and a brief history of TIME显示文摘 | Gregory SS David JB David WM | 2004 | International Wound Journal2004，1，： | 1 |
| 4 | Actln and actin-binding proteins in higher plants显示文摘 | David WM David RK Christopher JS | 2001 | Protoplasma2001，215，14： | 1 |
| 5 | Analgesia following total knee arthroplasty显示文摘 | Andrew T David WM | 2007 | J Curr Opin Orthop2007，18，11： | 1 |
| 6 | postinjury muhiple organ failure: the role of the gut显示文摘 | Heithan th bruce ck david wm | 2011 | shock2011，151，： | 1 |
| 7 | Analgesia following total knee arthroplasty显示文摘 | Andrew T David WM | 2007 | J Curr Opin Orthop2007，18，1： | 1 |
| 8 | Canstatin inhibits Akt activation and induces Fas-dependent apoptosis in endothelial Cells 显示文摘 | David J Panka James WM | 2003 | J Biol Chem2003，278，37： | 1 |
| 9 | Evaluation of the role of P - glycoprotein in the uptake of paroxetine, clozapine, phenytoin and carbamazapine by bovine retinal endothelial cells 显示文摘 | Lynn WM David AA Ellen BW | 2005 | Neuropharmacol2005，49，： | 1 |
| 10 | Wound bed prepartion and a brief history of time 显示文摘 | GREGORY SS DAVID JB DAVID WM | 2004 | Int Wound J2004，1，1： | 1 |
| 11 | Structure expressionand mutation of the hypoxanthine phosphoribosyltrans ferase gene显示文摘 | DAVID WM DAVID SK JOHN B | 1984 | Proc Nat Acad Sci1984，81，7： | 1 |
| 12 | Tissue Plasminpgen Activator Cerebrovascular Thrombolysis in Rabbits Is Dependent on the Rate and Route of Administration显示文摘 | David Russell Madden KP Clark WM | 1992 | Stroke1992，23，3： | 1 |
| 13 | Explaining how 'highgrade” systemic inflammation accelerates vascular risk in rheumatoid arthritis显示文摘 | Naveed S David WM Hilary C | | 0，，： | 1 |
| 14 | Connexin 40 promoter-based enrichment of embryonic stem cel-derived cardiovascular progenitor cel s显示文摘 | David R Theiss H Franz WM | | 0，，1： | 1 |
| 15 | Postinjury multiple organ failure:The role of the gut显示文摘 | Heithan TH Bruce CK David WM | 2001 | Shock2001，15，： | 1 |
| 16 | Cur- vature and leading edge sweep back effects on grid fin aero- dynamic characteristics 显示文摘 | Wm David Washington Pamela F Booth Mark S Miller | 1993 | AIAA-93-3480-Cp1993，，： | 1 |
| 17 | Post-injury multiple organ failure:the role of the gut显示文摘 | Heithan TH Bruce CK David WM | 2001 | Shock2001，15，： | 1 |
| 18 | Market orientation and new product development in global industrial firms 显示文摘 | BRENT M WREN WM E SOUDER DAVID BERKOWITZ | 2000 | Industrial Marketing Management2000，，29： | 1 |
| 19 | Mixing ratio of CaC12 and NaC1 for effective deicer 显示文摘 | L I David Jim WM c Graw Morris Mauritis JiW on Jang | 1997 | Journal of Materials in Civil Engineering1997，，5： | 1 |
| 20 | Postinjury multiple organ failure: The role of the gut 显示文摘 | Bruce CK David WM | 2001 | Shick2001，15，1： | 1 |
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