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| 1 | Antimicrobial peptides and the gut microbiome in inflammatory bowel disease显示文摘Antimicrobial peptides(AMP)are highly diverse and dynamic molecules that are expressed by specific intestinal epithelial cells,Paneth cells,as well as immune cells in the gastrointestinal(GI)tract.They play critical roles in maintaining tolerance to gut microbiota and protecting against enteric infections.Given that disruptions in tolerance to commensal microbiota and loss of barrier function play major roles in the pathogenesis of inflammatory bowel disease(IBD)and converge on the function of AMP,the significance of AMP as potential biomarkers and novel therapeutic targets in IBD have been increasingly recognized in recent years.In this frontier article,we discuss the function and mechanisms of AMP in the GI tract,examine the interaction of AMP with the gut microbiome,explore the role of AMP in the pathogenesis of IBD,and review translational applications of AMP in patients with IBD. | John Gubatan Derek R Holman Christopher J Puntasecca Danielle Polevoi Samuel JS Rubin Stephan Rogalla | 2021 | World Journal of Gastroenterology2021，27，43： | 3 |
| 2 | The inhibition of metallo β-lactamase by thioxo-cephalosporin derivatives显示文摘 | Wing YT Anupma D Christopher JS | 2004 | Bioorg & Med Chem2004，14，： | 1 |
| 3 | Actln and actin-binding proteins in higher plants显示文摘 | David WM David RK Christopher JS | 2001 | Protoplasma2001，215，14： | 1 |
| 4 | Protein kinase C-θ:signaling from the center of the T cell synapse显示文摘 | Christopher WA Bjorn A Timothy JS | 2002 | Current Opinion in Immunology2002，14，2： | 1 |
| 5 | Surveillance for HIV-1 incidence using tests for recent infection in resource-constrained countries 显示文摘 | MeDougal JS Christopher DP Bharat SP | 2005 | AIDS2005，19，2： | 1 |
| 6 | Linkage association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism 显示文摘 | Nicolas R Jennifer GR Christopher JS | 2004 | Am Psychiatry2004，161，： | 1 |
| 7 | Role of Chemerin/CMKLR1 signaling in adipogenesis and osteoblastogenesis of bone marrow stem cells显示文摘 | Shanmugam M Aleexandra AR Christopher JS | 2010 | J Bone Mine Res2010，25，2： | 1 |
| 8 | Ustekinumab Induction and Maintenance Therapy in Refractory Crohn's Disease显示文摘 | William JS Christopher G Long LG | 2012 | N En- gl J Med2012，367，： | 1 |
| 9 | linkage and association ot the mitochondrial aspartate /glutamate carrier SLC25A12 gane with antism显示文摘 | Nicolas R Jennifer GR Christopher JS | 2004 | Am J Psychiatry2004，161，： | 1 |
| 10 | Effects of Pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance显示文摘 | Christopher JS Michele E Karen G | 2001 | Diabetes2001，50，： | 1 |
| 11 | Towards an un- derstanding of mental toughness in elite English cricketers 显示文摘 | Stephen JB Christopher JS Wil J | 2005 | Journal of Applied Sport Psychology2005，17，3： | 1 |
| 12 | Linkage association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism显示文摘 | Nicolas R Jennifer GR Christopher JS | 2004 | Am Psychiatry2004，161，： | 1 |
| 13 | Isothioureas:potent inhibitors of nitric oxidesynthase with variable isoform selectivity显示文摘 | Carry JS Lsaba S Christoph T | 1995 | Br J Pharmacol1995，114，2： | 1 |
| 14 | The Rapamycin derivative RAD inhibits mesangial cell migration through the CDK- inhibitor p27KIP1显示文摘 | Christoph D Jeffrey P Stuart JS | 2004 | Lab Invest2004，84，4： | 1 |
| 15 | Coronary intervention for persistent occlusion aftermyocardial infarction显示文摘 | Hochman JS Lamas GA Christopher EB | 2006 | N Engl J Med2006，335，： | 1 |
| 16 | Coronary intervention for persistent occlusion after myocardial infarction显示文摘 | Hochman JS Lamas GA Christopher EB | 2006 | N Engl J Med2006，335，： | 1 |
| 17 | Performance of Xpert MTB/RIF on pleural tissue for the diagnosis of pleural tuberculosis显示文摘 | Christopher DJ Schumacher SG Michael JS | 2013 | Eur Respir J2013，42，5： | 1 |
| 18 | Identification of optimal contemporary antiemetic prophylaxis for doxorubicin-cyclophosphamide chemotherapy in Chinese cancer patients: post-hoc analysis of 3 prospective studies显示文摘Objective:Chemotherapy-induced nausea and vomiting(CINV)are common with doxorubicin-cyclophosphamide(AC)chemotherapy.Recommended antiemetic regimens incorporate neurokinin-1 receptor antagonist(NK1 RA),5-hydroxytryptamine type-3 receptor antagonist(5 HT3 RA),corticosteroid,and dopamine antagonists.This post-hoc analysis compared results of 3 prospective antiemetic studies conducted among Chinese breast cancer patients who received(neo)adjuvant AC,in order to identify optimal antiemetic prophylaxis.Methods:A total of 304 patients were included:Group 1,ondansetron/dexamethasone(D1);Group 2,aprepitant/ondansetron/dexamethasone(D1);Group 3,aprepitant/ondansetron/dexamethasone(D1–3);Group 4,aprepitant/ondansetron/dexamethasone(D1–3)/olanzapine;and Group 5,netupitant/palonosetron/dexamethasone(D1–3).Antiemetic efficacies of Groups 3,4,and 5 during cycle 1 of AC were individually compared with Group 1.In addition,emesis outcomes of patients in Groups 3 and 5,and those of Groups 2 and 3,were compared.Results:When comparing efficacies of a historical doublet(5 HT3 RA/dexamethasone)with triplet antiemetic regimens(NK1 RA/5 HT3 RA/dexamethasone)with/without olanzapine,complete response(CR)percentages and quality of life(QOL)in overall phase of cycle 1 AC were compared between Group 1 and the other groups:Group 1 vs.3,41.9%vs.38.3%(P=0.6849);Group 1 vs.4,41.9%vs.65.0%(P=0.0107);and Group 1 vs.5,41.9%vs.60.0%(P=0.0460).Groups 4 and 5 achieved a better QOL.When comparing netupitant-based(Group 3)with aprepitant-based(Group 5)triplet antiemetics,CR percentages were 38.3%vs.60.0%,respectively(P=0.0176);Group 5 achieved a better QOL.When comparing 1 day(Group 2)vs.3 day(Group 3)dexamethasone,CR percentages were 46.8%and 38.3%,respectively(P=0.3459);Group 3 had a worse QOL.Conclusions:Aprepitant-containing triplets were non-superior to doublet antiemetics.Netupitant-containing triplets and adding olanzapine to aprepitant-containing triplets were superior to doublets.Netupitant/palonosetron/dexamethasone was superior to aprepitant/ondansetron/dexamethasone.Protracted administration of dexamethasone provided limited additional benefit. | Winnie Yeo Leung Li Thomas KH Lau Kwai T Lai Vicky,TC Chan Kwan H Wong Christopher CH Yip Elizabeth Pang Maggie Cheung Vivian Chan Carol CH Kwok Joyce JS Suen Frankie KF Mo | 2021 | Cancer Biology & Medicine2021，18，3： | 0 |
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