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	题名	作者	年代	出处	被引量
1	Hepatocellular carcinoma xenograft supports HCV replication:A mouse model for evaluating antivirals显示文摘AIM: To develop a hepatocellular carcinoma (HCC) xenograft model for studying hepatitis C virus (HCV) replication in a mice, and antiviral treatment.METHODS: We developed a stable S3-green fluorescence protein (GFP) cell line that replicated the GFP-tagged HCV sub-genomic RNA derived from a highly efficient JFH1 virus. S3-GFP replicon cell line was injected subcutaneously into γ-irradiated SCID mice. We showed that the S3-GFP replicon cell line formed human HCC xenografts in SCID mice. Cells were isolated from subcutaneous tumors and then serially passaged multiple times in SCID mice by culturing in growth medium supplemented with G-418. The mouse-adapted S3-GFP replicon cells were implanted subcutaneously and also into the liver of SCID mice via intrasplenic infusion to study the replication of HCV in the HCC xenografts. The tumor model was validated for antiviral testing after intraperitoneal injection of interferon-α (IFN-α). RESULTS: A highly tumorigenic S3-GFP replicon cell line was developed that formed subcutaneous tumors within 2 wk and diffuse liver metastasis within 4 wk in SCID mice. Replication of HCV in the subcutaneous and liver tumors was confirmed by cell colony assay, detection of the viral RNA by ribonuclease protection assay and real-time quantitative reverse transcription polymerase chain reaction. High-level replication of HCV sub-genomic RNA in the tumor could be visualized by GFP expression using fluorescence microscopy. IFN-α cleared HCV RNA replication in the subcutaneous tumors within 2 wk and 4 wk in the liver tumor model. CONCLUSION: A non-infectious mouse model allows us to study replication of HCV in subcutaneous and metastatic liver tumors. Clearance of HCV by IFN-α supports use of this model to test other anti-HCV drugs.	Sidhartha Hazari Henry J Hefler Partha K Chandra Bret Poat Feyza Gunduz Tara Ooms Tong Wu Luis A Balart Srikanta Dash	2011	World Journal of Gastroenterology2011，17，3：	2
2	Stent st rut fracture-induced restenosis in a bifurcation lesion treated with the crush stenting technique 显示文摘	SURMELY J F KINOSHITA Y DASH D	2006	Circ J2006，70，：	1
3	Effect of pore size and surface area of carbide derived carbons on specific capacitance显示文摘	Chmiola J Yushin G Dash R	2006	Journal of Power Sources2006，158，1：	1
4	Decresased levels of plasma vitamin C and increased concentrations of inflammatory and oxidative seress marker after stroke显示文摘	SANCHEZ-MORENO C DASHE J F SCOTT T	2004	Stroke2004，35，1：	1
5	Lymphomas and high-grade astrocytomas: comparison of water dif- fusibility and histologic characteristics 显示文摘	Guo A C Cummings T J Dash R C	2002	Radiology2002，224，1：	1
6	Entropy-based fuzzy clustering and modeling 显示文摘	YAO J DASH M TAN S T	2000	Fuzzy Sets and Systems2000，113，3：	1
7	Lymphomas and high gradeastrocytomas:comparison of water diffusibility and histologic char-acteristics显示文摘	Guo A C Cumming T J Dash R C	2002	Radiology2002，224，1：	1
8	Alpha-fetoproteni detection of neural tube defects and the impact of standard ultrasound显示文摘	Dashe J S Twickler D M Santos R R	2006	Am J Obstet Gynecol2006，195，6：	1
9	Altered expression of miRNA- 21 and its targets in the hippocampus 'after traumatic brain injury 显示文摘	Redell JB Zhao J Dash PK	2011	J Neurosci Res2011，89，2：	1
10	Utility of Doppler velocimetry in predicting outcome in twin reversed-arterial perfusion sequence显示文摘	Dashe J S Fernandez C O Twickler D M	2001	Am J Obstet Gynecol2001，185，1：	1
11	Surface Morphology and Microcomposition of Palladium Cathodes After Electrolysis in Acidified Light and Heavy Water:Correlation With Excess Heat显示文摘	Dash J Noble G Diman D	1994	Trans Fusion Technology1994，26，：	1
12	The premelting of ice and its environmental consequences 显示文摘	DASH J G FU H WETTLAUFER J S	1999	Rep Prog Phys1999，58，：	1
13	Thermomolecular pressure in surface melting:Motivation for frost heave显示文摘	Dash J G		0，，：	1
14	The premehing of ice and its environmental sequences 显示文摘	DASH J D FU H WETrLAUFER J S	1995	Reports on Progress in Physics1995，58，：	1
15	Pituitary adenoma and parasagittal meningioma: an unusual association显示文摘	Mathuriya SN Vasishta RK Dash R J	2000	Neurol India2000，48，：	1
16	Theory of ice premelting in monosized powders显示文摘	Cahn J W Dash J G Fu Haiying		0，，1：	1
17	Entropy-based fuzzy clustering and fuzzy modeling显示文摘	Yao J Dash M Tan S T	2000	Fuzzy Sets and Systems2000，13，3：	1
18	Entropy-based fuzzy clustering and fuzzy modeling显示文摘	Yao J Dash M Tan S T	2000	Fuzzy Sets and Systems2000，113，3：	1
19	Frost heave in argon显示文摘	Zhu D-M Vilches O E Dash J G		0，，23：	1
20	Effect of compressive load on uplift capacity of model piles显示文摘	B K Dash P J Pise	2003	Journal of Geotechnical and Geoenvironmental Engineering2003，129，11：	1

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