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	题名	作者	年代	出处	被引量
1	Differences in viral kinetics between genotypes 1 and 3 of hepatitis C virus and between cirrhotic and non-cirrhotic patients during antiviral therapy显示文摘AIM: To evaluate the impact of hepatitis C virus (HCV) infection with genotype 1 or 3 and the presence or absence of liver cirrhosis (LC) in the early viral kinetics response to treatment. METHODS: Naive patients (n = 46) treated with interferon-α (IFN-α) and ribavirin and followed up with frequent early HCV-RNA determinations were analysed. Patients were infected with genotype 1 (n = 28, 7 with LC) or 3 (n = 18, 5 with LC). RESULTS: The fi rst phase decline was larger in geno- type 3 patients than in genotype 1 patients (1.72 vs 0.95 log IU/mL, P < 0.001). The second phase slope decline was also larger in genotype 3 patients than in genotype 1 patients (0.87 vs 0.15 log/wk, P < 0.001). Differences were found in both cirrhotic and non-cirrhotic patients. Genotype 1 cirrhotic patients had a slower 2nd phase slope than non-cirrhotic patients (0.06 vs 0.18 log/wk, P < 0.02). None of genotype 1 cirrhotic patients had a 1st phase decline larger than 1 log (non-cirrhotic patients: 55%, P < 0.02). A similar trend toward a slower 2nd phase slope was observed in genotype 3 cirrhotic pa- tients but the 1st phase slope decline was not different. Sustained viral response was higher in genotype 3 pa- tients than in genotype 1 patients (72% vs 14%, P < 0.001) and in genotype 1 non-cirrhotic patients than in genotype 1 cirrhotic patients (19% vs 0%). A secondphase decline slower than 0.3 log/wk was predictive of non-response in all groups. CONCLUSION: Genotype 3 has faster early viral decline than genotype 1. Cirrhosis correlates with a slower 2nd phase decline and possibly with a lower 1st phase slope decline in genotype 1 patients.	José Eymard Medeiros-Filho Isabel Maria Vicente Guedes de Carvalho Mello Joo Renato Rebello Pinho Avidan U Neumann Fernanda de Mello Malta Luiz Caetano da Silva Flair José Carrilho	2006	World Journal of Gastroenterology2006，12，45：	3
2	Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays 显示文摘	Barkai N Notterman DA	1999	Proc Natl Acad Sci U S A1999，96，12：	1
3	Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors显示文摘	Kafri T Blomer U Peterson DA	1997	Nat Genet1997，17，2：	1
4	Featureso airway remodelingand eosinophilicinflammationin chroni- crhinosinusitis: is the histopathology similar to asthma 显示文摘	Ponikauj U Sherris DA Kephart GM	2010	JAllergy Clin Immunol2010，112，：	1
5	Treatment of long term anterior dislocation of the TMJ显示文摘	DA Baur JR Jannuzzi U Mercan	2013	Int J Oral Maxillofac Surg2013，42，：	1
6	A simple solid injection device for the analyses of Bulbophyllum (Orchidaceae) volatiles 显示文摘	da Silva U F Borba E L Semir J Marsaioli A J	1999	Phytochemistry1999，50，：	1
7	Inhibitory effect of 2- arylbenzofurans from the Mori Cortex Radicis (Moraceae) on oxygen glucose deprivation (OGD) induced cell death of SH-SY5Y cells 显示文摘	Lee HJ Lyu da H Koo U	2011	Arch Pharm Res2011，34，8：	1
8	Fundamentals of pulmonary drug delivery显示文摘	Groneberg DA Witt C Wanger U		0，，04：	1
9	Estradiol, FSH and LH profiles in nine ethnic groups of postmenopausal Asian women: the Pan-Asia Menopause (PAM) study显示文摘	AUSMANAS MK TAN DA JAISAMRARN U	2007	Climacteric2007，10，5：	1
10	Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays 显示文摘	ALON U BARKAI N NOTTERMAN DA	1999	Proc Natl Acad Sci USA1999，96，12：	1
11	Geographic distribution of vacA allelic types of Helicobacter pylori显示文摘	Leen–Jan Van Doorn Céu Figueiredo Francis Mégraud Salvador Pena Peter Midolo Dulciene Maria De Magalh?es Queiroz Fátima Carneiro Bart Vanderborght Maria Da Glória F. Pegado Ricardo Sanna Wink De Boer Peter M. Schneeberger Pelayo Correa Enders K.W. Ng John	1999	Gastroenterology1999，，4：	1
12	Flooding effects on phosphorus dynamics in an Amazonian mangrove forest, Northern Brazil 显示文摘	MENDOZA U N DA CRUZ C C MENEZES MP	2012	Plant and Soil2012，353，：	1
13	Intestinal permeability and systemic infec-tious in critically ill patients: effect of glutamine 显示文摘	De -Souza DA Greene U	2005	Grit Care Med2005，33，5：	1
14	Li- popolysaccharide is in close proximity to each of the proteins in its membrane recept or complex transfer from CD14 to TLR4 and MD - 2显示文摘	DA SILVA CORREIA J SOLDAU K CHRISTEN U	2001	J Biol Chem2001，276，21：	1
15	Catalytic activity and stability of a chromium containing silicate in liquid phase cyclohex- ane oxidation 显示文摘	da Cruz R S e Silva J M S Aruold U I	2001	Journal of Molecular Catalysis A : Chemical2001，171，1：	1
16	Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucletide arrays显示文摘	Alon U Barkai N Noterman DA	1999	Proc Natl Acad Sci USA1999，96，12：	1
17	Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays显示文摘	Alon U Barkai N Notterman DA		0，，：	1
18	Quantification of bias related to the extraction of DNA directly from soils显示文摘	Frostegar DA Courtois S Ramisse U	1999	Ap- plied and Environmental Microbiology1999，，65：	1
19	Transcatheter aortic valve implantation for pure severe native aortic valve regurgitation显示文摘	Roy DA Schaefer U Guetta V	2013	J Am Coll Cardiol2013，61，15：	1
20	Use of partial 16S rRNA gene sequencing for identification of Legionella pneurnophila and non-pneumophila Legionella spp 显示文摘	Wilson DA Reischl U Hall GS	2007	J Clin Microbiol2007，45，1：	1

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