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| 1 | Influence of antibiotic-regimens on intensive-care unit-mortality and liver-cirrhosis as risk factor显示文摘AIM: To assess the rate of infection, appropriateness of antimicrobial-therapy and mortality on intensive care unit(ICU). Special focus was drawn on patients with liver cirrhosis.METHODS: The study was approved by the local ethical committee. All patients admitted to the Internal Medicine-ICU between April 1, 2007 and December 31, 2009 were included. Data were extracted retrospectively from all patients using patient charts and electronic documentations on infection, microbiological laboratory reports, diagnosis and therapy. Due to the large hepatology department and liver transplantation center, special interest was on the subgroup of patients with liver cirrhosis. The primary statistical-endpoint was the evaluation of the influence of appropriate versusinappropriate antimicrobial-therapy on in-hospitalmortality.RESULTS: Charts of 1979 patients were available. The overall infection-rate was 53%. Multiresistantbacteria were present in 23% of patients with infection and were associated with increased mortality(p < 0.000001). patients with infection had significantly increased in-hospital-mortality(34% vs 17%, p < 0.000001). Only 9% of patients with infection received inappropriate initial antimicrobial-therapy, no influence on mortality was observed. Independent risk-factors for in-hospital-mortality were the presence of septicshock, prior chemotherapy for malignoma and infection with pseudomonas spp. Infection and mortality-rate among 175 patients with liver-cirrhosis was significantly higher than in patients without liver-cirrhosis. Infection increased mortality 2.24-fold in patients with cirrhosis. patients with liver cirrhosis were at an increased risk to receive inappropriate initial antimicrobial therapy.CONCLUSION: The results of the present study report the successful implementation of early-goal-directed therapy. Liver cirrhosis patients are at increased risk of infection, mortality and to receive inappropriate therapy. Increasing burden are multiresistant-bacteria. | Mireen Friedrich-Rust Beate Wanger Florian Heupel Natalie Filmann Reinhard Brodt Volkhard AJ Kempf Johanna Kessel Thomas A Wichelhaus Eva Herrmann Stefan Zeuzem Joerg Bojunga | 2016 | World Journal of Gastroenterology2016，22，16： | 6 |
| 2 | Effect of endothelin in man显示文摘 | Vierhaper H Wanger O N owotny P | 1990 | circulation1990，81，7： | 2 |
| 3 | APACHE Ⅱ : a severity of disease classification system 显示文摘 | Knaus WA Draper EA Wanger DP | 1985 | Crit Care Med1985，13，： | 1 |
| 4 | Nosocomial outbreak caused by a multiresistant clone of Acinetobacter bau rnannii ; results of the ease control and molecular epidemiologic investigations显示文摘 | Scerpella E G Wanger A R Armitige L | 1995 | Infect Control Hosp Epidemiol1995，16，2： | 1 |
| 5 | Fiber-fortified feedings in immobile patients 显示文摘 | Grant LP Wanger LI Neill KM | 1994 | Clin Nurs Res1994，3，2： | 1 |
| 6 | Impronement of nitrc oxide-dependent vasadilation by HMG-COA reductase inhibitors through attenuation of endothelial superoxide anionformation显示文摘 | Wanger A H kohler J Buckschass U | 2000 | Arteriascl Thramb vase Bial2000，20，1： | 1 |
| 7 | Replica- rive senescence of human endothelial cells in vitro involves G, arrest, Polyploization and senescence- associated apoptosis 显示文摘 | Wanger M Hampel B Bernhard D | 2001 | gxp Gerontol2001，36，8： | 1 |
| 8 | Accumulation of cadmium in crop plants and its consequences to human health显示文摘 | Wanger G J | 1993 | Adv Agron1993，51，： | 1 |
| 9 | Accumulation of cadmium ill plants and its consequences to human heath显示文摘 | WANGER G J | 1993 | Advanced in Agronomy1993，51，： | 1 |
| 10 | APACHE Ⅱ: a severity of classification system显示文摘 | Knaus Wh Draper EA Wanger DP | 1985 | Crit Care Med1985，13，0： | 1 |
| 11 | Feeder reconfiguration for loss reduction: an application of distribution of distribution automation 显示文摘 | Wanger T P Chikani AY Haekam R | 1991 | IEEE Trans on Power Delivery1991，6，4： | 1 |
| 12 | Cord Blood transplantation study (COBLT) : Cord blood bank standard operating procedures显示文摘 | Fraser JK Cairo MS Wanger EL | 1998 | J Hematother1998，7，6： | 1 |
| 13 | Demonstration of renin mRNA,angiotension mRNA,and argiotensin converting enzyme mRNA expression in the human eye显示文摘 | Wanger J Danser A Perkx F | 1996 | Br J Ophthalmol1996，80，： | 1 |
| 14 | Toll-like receptor 2 participates in mediation of immune response in experimental pneumococcal meningitis显示文摘 | Koedel U Angele B Rupprecht T Wanger H Roggenkamp A Pfister HW | 2003 | J Immunol2003，170，1： | 1 |
| 15 | Nevadensin Glycosides from Lysinotus pauciflorus显示文摘 | Liu Y Wanger H Bauer R | | 0，，04： | 1 |
| 16 | Mechanical surface treatment on titanium and aluminum and magnesium alloy 显示文摘 | Wanger L | 1999 | Mater Science and Engineering A1999，263，2： | 1 |
| 17 | Corrosion fatigue behavior of the high strength Magnesium AZS0显示文摘 | Hilpert M Wanger L | 2000 | Journal of Material Engineering and Performance2000，9，： | 1 |
| 18 | APACHE Ⅱ:a severity of classification system显示文摘 | Knaus WA Draper EA Wanger DP | 1985 | Crit Care Med1985，13，40： | 1 |
| 19 | Estimating the economic impacts of tourism 显示文摘 | Wanger J | 1997 | Annals of Tourism Research1997，24，3： | 1 |
| 20 | Is HLA-DR4 or the HLA-DRB1* 0402 allele associated with decreased risk for CML显示文摘 | Pawelec G Wanger W | 2001 | Leukemia2001，14，3： | 1 |
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