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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | 长期应用埃索美拉唑是维持已愈合糜烂性食管炎疗效及控制胃食管反流症状的有效方法显示文摘 | Johnson DA Benjamin SB Vakil NB Goldstein JL Lamet M Whipple J Damico D Hamelin B 钟捷 | 2002 | 中华消化杂志2002，22，12： | 6 |
| 3 | Ly49 receptors activate angiogenic mouse DBA+ uterine natural killer cells显示文摘 | Patricia DA Lima Megan M Tu Mir Munir A Rahim Annie R Peng B Anne Croy Andrew P Makrigiannis | 2014 | Cellular & Molecular Immunology2014，11，5： | 3 |
| 4 | Quantification of catechin and poranthocyanidins in several portuguese grapevine varieties and red wines 显示文摘 | Sun B S Ricardo da Silva J Mv Spranger M | 2001 | Ciencia E Tecnica Vitivinico- la2001，16，1： | 1 |
| 5 | Parametric Study of Adhesive Joints with Composites 显示文摘 | NETO J A B P CAMPILHO R D S G DA SILVA L F M | 2012 | International Journal of Adhesion and Adhesives2012，，： | 1 |
| 6 | Scientific Collaboration in Biotechnology : the Case of the Northeast Region in Brazil 显示文摘 | Costa B M G da Silva Pedro E de Macedo G R | 2013 | Scientometrics2013，，： | 1 |
| 7 | Characterization of Pore Systems in Seal Rocks Using Nitrogen Gas Adsorption Combined with Mercury Injection Capillary Pressure Techniques 显示文摘 | Schmitt M Fernandes C P da Cunha Neto J A B | 2013 | Marine and Petroleum Geology2013，39，1： | 1 |
| 8 | Sphingusine regulates the tran scription of CYP17 by binding to steroidogenic factor-1 显示文摘 | Urs A N Da mer E Sewer M B | 2006 | Endocrinology2006，147，： | 1 |
| 9 | Analysis and software implementation of a robust synchronizing PLL circuit based on the pq theory显示文摘 | Rolim L G B da Costa D R Aredes M | 2006 | IEEE Trans on Industrial Electronics2006，53，6： | 1 |
| 10 | Induction motor drive system for low power applications显示文摘 | C B Jacobina M B de Rossiter Correa E R C da Silva | | 0，，01： | 1 |
| 11 | Recovery of rhamnolipids produced by pseudomonas aeruginosa using acidic precipitation, extraction, and ad- sorption on activated carbon 显示文摘 | CARMENDSM D O A DA S B M DE A PC E | 2013 | Separation Science and Technology2013，48，18： | 1 |
| 12 | Venompresent in sea anemone (Heteractis magnifica)induces apoptosis innon-small-cell lung cancer A549 cells through activation of mito-chondria-mediated pathway显示文摘 | RAMEZANPOUR M DA SILVA K B SANDERSON B J | 2014 | Biotechnol Lett2014，36，3： | 1 |
| 13 | Bonded Repair of Composite Aircraft Structures:A Review of Scientific Challenges And Opportunities显示文摘 | Katnam K B Da Silva L Young T M | 2013 | Progress in Aerospace Sciences2013，，61： | 1 |
| 14 | Two naturally occurring amino acid substitutions in the human 5-HT1A receptor:glycine 22 to serine 22 and isoleucine 28 to valine 28显示文摘 | Nakhai B Nielsen DA Linnoila M Goldman D | | 0，，： | 1 |
| 15 | Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection 显示文摘 | Petrovas C Chaon B Amhrozak DR Price DA Melen- horst JJ Hill BJ Geldmacher C Casazza JP Chatto- padhyay PK Roederer M Douek DC Mueller YM Jacob- son JM Kulkarni V Felber BK Pavlakis GN Katsikis PD Koup RA | 2009 | J Immunol2009，183，2： | 1 |
| 16 | Anticancer, antichemotactic and antimicrobial activities of marine sponges collected off the coast of Santa Catarina, southern Brazil显示文摘 | Noel R Monks Clea Lerner Amélia T Henriques Fabiane M Farias Elfrides E.S Schapoval Edna S Suyenaga Adriana B da Rocha Gilberto Schwartsmann Beatriz Mothes | 2002 | Journal of Experimental Marine Biology and Ecology2002，，1： | 1 |
| 17 | Iatrogenic ureteral lesions and repair: A review forgynecologists 显示文摘 | DE CICCO C RET DA VALOS M L VAN CLEYNENBREUGEL B | 2007 | J Minim Invasive Gynecol2007，14，4： | 1 |
| 18 | Enalapril attenuates angiotensin Ⅱ-induced atherosclerosis and vascular inflammation显示文摘 | Da Cunha V Tham D M Martin-McNulty B | 2005 | Atherosclerosis2005，178，1： | 1 |
| 19 | Screening Botryosphaeria species for lipases:Production of lipase by Botryosphaeria ribis EC-01 grown on soybean oil and other carbon sources显示文摘 | Mwssias J M da Costa B Z de Lima V M G | 2009 | Enzyme and Microbial Technology2009，45，67： | 1 |
| 20 | Enalapril attenuates angiotensin Ⅱ -induced atheroselerosis and vascular inflammation显示文摘 | DA CUNHA V THAM D M MARTIN-MCNULTY B | 2005 | Atherosclerosis2005，178，： | 1 |
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