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| 1 | Fecal lactoferrin accurately reflects mucosal inflammation in inflammatory bowel disease显示文摘BACKGROUND Studies have demonstrated a potential role for fecal biomarkers such as fecal calprotectin(FC)and fecal lactoferrin(FL)in monitoring inflammatory bowel diseases(IBD)-Crohn's disease(CD)and ulcerative colitis(UC).However,their correlation to endoscopic scores,disease severity and affected intestinal surface has not been extensively investigated.AIM To correlate FL,and for comparison white blood cell(WBC)and C-reactive protein(CRP),with endoscopic scores,disease extent and location in CD and UC.METHODS Retrospective analysis in 188 patients who had FL,CRP and WBC determined within 30 d of endoscopy.Disease location,disease extent(number of intestinal segments involved),disease severity(determined by endoscopic scores),timing of FL testing in relation to colonoscopy,as well as the use of effective fast acting medications(steroids and biologics)between colonoscopy and FL measurement,were recorded.RESULTS In 131 CD and 57 UC patients,both CRP and FL-but not WBC-distinguished disease severity(inactive,mild,moderate,severe).In patients receiving fastacting(steroids or biologics)treatment in between FL and colonoscopy,FL showed a higher correlation to endoscopic scores when tested before vs after the procedure(r=0.596,P<0.001,vs r=0.285,P=0.15 for the Simple Endoscopic Score for CD;and r=0.402,P=0.01 vs r=0.054 P=0.84 for Disease Activity Index).Finally,FL was significantly correlated with the diseased mucosal surface(colon-ileocolon>small bowel)and the number of inflamed colon segments.CONCLUSION FL and CRP separated disease severity categories with FL showing lower discriminating P-values.FL showed a close correlation with the involved mucosal surface and with disease extent and was more closely correlated to endoscopy when determined before the procedure–this indicating that inflammatory activity changes associated with therapy might be rapidly reflected by FL levels.FL can accurately and timely characterize intestinal inflammation in IBD. | Marrieth G Rubio Kofi Amo-Mensah James M Gray Vu Q Nguyen Sam Nakat Douglas Grider Kim Love James H Boone Dario Sorrentino | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，5： | 4 |
| 2 | Identification and expansion of human colon-cancer-initiating cells显示文摘 | LUCIA R V DARIO G L EMANUELA P | 2007 | Nature2007，445，： | 1 |
| 3 | Crush syndrome 显示文摘 | Dario G | 2005 | Crit Care Med2005，33，1： | 1 |
| 4 | Capsule endoseopy: from current achieve- ments to open challenges显示文摘 | Ciuti G Meneiassi A Dario P | 2011 | IEEE Reviews in Biomedical Engineering2011，4，： | 1 |
| 5 | Advances in the application of information technology to sport performance 显示文摘 | Dario G Liebermann Larry Katz Mike D Hughes et at | 2002 | Journal of Sports Sciences2002，20，： | 1 |
| 6 | Subtemporal suboc cipital transpetrosal transsigmoidal approach to aneurysm of the basilar artery fenestration显示文摘 | Scamoni C Dario A Spriano G | 1998 | J Neurosurg Sci1998，42，3： | 1 |
| 7 | Identification and expansion of human colon-cancer-initiating cells显示文摘 | Lucia RV Dario G Lombardi DG | 2007 | Nature2007，445，4： | 1 |
| 8 | The Doublesex Homolog Dmrt5 is Required for the Development of the Caudomedial Cerebral Cortex in Mammals显示文摘 | Amandine Saulnier Marc Keruzore Sarah De Clercq Isabelle Bar Virginie Moers Dario Magnani Tessa Walcher Carol Filippis Sadia Kricha Damien Parlier Laurène Viviani Clinton K. Matson Yasushi Nakagawa Thomas Theil Magdalena G?tz Antonello Mallamaci Jean-Chri | 2013 | Cerebral Cortex2013，，11： | 1 |
| 9 | High performance spectroradiometer for very accurate radiometric calibrations and testing of blackbody sources and EO test equipment 显示文摘 | DARIO C AMIR G BUCKWALD R A | 2006 | SPIE2006，6207，： | 1 |
| 10 | An integrated system for wireless capsule endoscopy in a liquid-distended stomach 显示文摘 | DE FALCO I TORTORA G DARIO P | 2014 | IEEE transactions on biomedical engineering2014，61，3： | 1 |
| 11 | Robotics for medical applications显示文摘 | Dario P Gu G | | 0，，03： | 1 |
| 12 | Anthropomorphic robot finger for investigating artificial tactile perception 显示文摘 | Dario P Buttazzo G | 1987 | Inter J Robotics Research1987，6，3： | 1 |
| 13 | The subjective components of happiness and their attainment:a cross - cultural comparison between Italy and Cuba显示文摘 | Dario G Mayra M Lgor $ | 2006 | Soc Sci Inform2006，45，4： | 1 |
| 14 | Capsule endoscopy:from current achievements to open challenges显示文摘 | CIUTI G MENCIASSI A DARIO P | 2011 | Biomedical Engineering IEEE Reviews in2011，4，： | 1 |
| 15 | Crush syndrome显示文摘 | Dario G | 2005 | Crit Care Med2005，33，1： | 1 |
| 16 | Capsule endosco- py: from current achievements to open challenges 显示文摘 | CIUTI G MENCIASSI A DARIO P | 2011 | IEEE Reviews in Biomedical Engineering2011，，4： | 1 |
| 17 | Crush syndrome显示文摘 | Dario G | 2005 | Crit Care Med2005，33，： | 1 |
| 18 | Panic disorder:the role of the balance system显示文摘 | Perna G Dario A Caldirola D | 2001 | J Psychiatr Res2001，35，5： | 1 |
| 19 | Capsule endoscopy: Fromcurrent achievements to open challenges显示文摘 | Ciuti G Menciassi A Dario P | 2011 | IEEE Reviews inBiomedical Engineering2011，4，： | 1 |
| 20 | Development of a low-cost active 3D triangulation laser scanner for indoor navigation of miniature mobile robots显示文摘 | Fu G Menciassi A Dario P | 2012 | Robotics and Autonomous Systems2012，60，10： | 1 |
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