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| 1 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 2 | Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium显示文摘 | Locovei S Wang J Dahl G | 2006 | FEBS Lett2006，580，1： | 1 |
| 3 | Developments and Chal- lenges in the Utilization of Magnesium Alloys 显示文摘 | Dahle A K John D H Dunlop G L | 2000 | Mater Forum2000，，24： | 1 |
| 4 | Proteome analysis of conditioned medium from cultured adult hippocampal progenitors显示文摘 | Dahl A Eriksson P S Persson A I Karlsson G Davidsson P Ekman R | | 0，，： | 1 |
| 5 | Context depend- ent pretrained deep neural networks {or large vocabu- lary speech recognition显示文摘 | Dahl G E Dong Yu Li Deng | 2012 | IEEE Transactions on Au- dio Speech and Language Processing2012，20，1： | 1 |
| 6 | Baker's yeast:production of D-and L-3-hydroxy esters显示文摘 | Allan C Dahl and Madsen J G | 1998 | Tetrahedron:Asymmetry1998，9，： | 1 |
| 7 | Geochemical characterization of a tar mat in the Oseberg Field Norwegian Sector,North Sea显示文摘 | Dahl B Speers G C | 1985 | Org Geochem1985，10，： | 1 |
| 8 | Increased incidence of cancer in adult Gaucher disease in Western Europe显示文摘 | DE FOST M VOM DAHL S WEVERLING G J | 2006 | Blood Cells Mol Dis2006，36，1： | 1 |
| 9 | The antimicrobial effect of calcium hydroxide in root canals pretreated with 5% iodinepotassium iodium显示文摘 | Molander A Reit C Dahlén G | 1999 | Endod Dent Traumatol1999，15，5： | 1 |
| 10 | Isolation and structure of higher diamondoids,nanometer-sized diamond molecules显示文摘 | Dahl J E Liu S G Carlson R M K | 2003 | Science2003，299，5603： | 1 |
| 11 | Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a double-blind, randomised controlled trial显示文摘 | Ajay K Kakkar Benjamin Brenner Ola E Dahl Bengt I Eriksson Patrick Mouret Jim Muntz Andrea G Soglian ákos F Pap Frank Misselwitz Sylvia Haas | 2008 | The Lancet2008，，9632： | 1 |
| 12 | Acoustic modeling using deep belief networks显示文摘 | Mohamed A Dahl G I-Iinton G | 2012 | IEEE Transactions on Audio Speech and Language Processing2012，20，1： | 1 |
| 13 | 5-year follow up of periodontal intraosseous defects treated by root planing or flap surgery显示文摘 | Nilvéus R Dahlén G | 1990 | J Clin Periodontol1990，17，6： | 1 |
| 14 | Large-scale integer programs inimage analysis显示文摘 | Dahl G Storvik G Fadnes A | 2002 | Operation Researth2002，50，3： | 1 |
| 15 | Dentin matrix protein 1 initiates hydroxyapatite formation in vitro显示文摘 | He G Dahl T Veis A | 2003 | Connect Tissue Res2003，44，1： | 1 |
| 16 | Minimal residual diseased therapy for childhood acute myeloid leukaemia: results of the AML02 multicentre trial 显示文摘 | Rubnitz JE Inaba H Dahl G | 2010 | Lancet Oncol2010，11，6： | 1 |
| 17 | Streptococci from root canals in teeth with apical periodontitis receiving endodontic treatment显示文摘 | Chávez De Paz L Svens?ter G Dahlén G | 2005 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2005，100，2： | 1 |
| 18 | RAPD fingerprinting used for discriminating among three populations of Hilsa shad (Tenualosa ilisha)显示文摘 | Rahman M Eriksen A G | 1997 | Fisheries Research1997，32，： | 1 |
| 19 | Cytotoxicity of dental alloys,met-als,and ceramics assessed by millipore filter,agar overlay,andMTT tests显示文摘 | Sjogren G Sletten G Dahl JE | 2000 | Prosthet Dent2000，84，2： | 1 |
| 20 | Clincal efficacy of L- ornithine -L-aspartate in the management of hepatic encephalopathy显示文摘 | Kireheis G Wettstein M Dahl S | 2002 | Metab Brain Dis2002，17，： | 1 |
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