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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Immobilization of commercial laccase on spent grain显示文摘 | da Silva A M Tavare A P M Rocha C M R | 2012 | Process Biochem2012，479，7： | 1 |
| 3 | Molecular differenc- es between hydrocarbon and fluorocarbon surfaetants at the COJ water interface 显示文摘 | Stone M T Da Rocha S R P Rossky P J | 2003 | Journal of Physics Chemistry2003，107，10： | 1 |
| 4 | Anticancer, antichemotactic and antimicrobial activities of marine sponges collected off the coast of Santa Catarina, southern Brazil显示文摘 | Noel R Monks Clea Lerner Amélia T Henriques Fabiane M Farias Elfrides E.S Schapoval Edna S Suyenaga Adriana B da Rocha Gilberto Schwartsmann Beatriz Mothes | 2002 | Journal of Experimental Marine Biology and Ecology2002，，1： | 1 |
| 5 | Facial nerve in rhytidoplasty:anatomic study of its trajectory in the overlying skin and the most common sites of injury显示文摘 | FADUL R Jr Da ROCHA M A | 2003 | Ann Plast Surg2003，51，3： | 1 |
| 6 | 3xP3-EGFP maker facilitates screening for transgenic silkworm Bombyx moriL, from the embryonic stage onwards 显示文摘 | THOMAS J L DA ROCHA M BESSE A | 2002 | Insect Biochemistry and Molecular Biology2002，32，： | 1 |
| 7 | Identification of androgen, estrogen and progesterone receptor mRNAs in the eye 显示文摘 | Wickham LA Gao J Toda I Rocha EM Ono M Sullivan DA | 2000 | Acta Ophthalmol Scand2000，78，2： | 1 |
| 8 | An experimental and theoretical analysis on the application of stress -based forming limit criterion 显示文摘 | BUTUC M C GRACIO J J BARATA DA ROCHA A | 2006 | International Journal of Mechanical Sciences2006，48，4： | 1 |
| 9 | The role of natural products in the discovery of new drug candidates for the treatment of neurodegenerative disorders II: Alzhe- imer' s disease 显示文摘 | Campos H C da Rocha M D Viegas F P | 2011 | CNS Neurol Disord Drug Targets2011，10，2： | 1 |
| 10 | Identification of androgen,estrogen and progesterone receptor mRNAs in the eye显示文摘 | Wickham LA Gao J Toda I Rocha EM Ono M Sullivan DA | | 0，，02： | 1 |
| 11 | TERT promoter mutations are a major indicator of poor outcome in differ- entiated thyroid carcinomas显示文摘 | Melo M da Rocha AG Vinagre J | 2014 | J Clin Endocrinol Metab2014，99，5： | 1 |
| 12 | Flavonoids and antiulcerogenic activity from Byrsonima crassa leaves extracts显示文摘 | Sannomiya M Fonseca VB da Silva MA Rocha LR Dos Santos LC Hiruma-Lima CA Souza Brito AR Vilegas W | | 0，，1： | 1 |
| 13 | Immunocytochemical location and hormonal control of androgen receptors in lacrimal tissues of the female MRL/Mp-lpr/lpr mouse model of Sjogren' s syndrome显示文摘 | Ono M Rocha F J Sullivan DA | 1995 | Exp Eye Res1995，61，6： | 1 |
| 14 | Proline accu- mulation and glutamine synthetase activity are increased by salt- induced proteolysis in cashew leaves 显示文摘 | Silveria J A Viegas Rde A da Rocha I M | 2003 | J Plant Physiol2003，160，2： | 1 |
| 15 | Natural products in anticancer therapy显示文摘 | Adriana B da Rocha Rafael M Lopes Gilberto Schwartsmann | 2001 | Cancer2001，1，： | 1 |
| 16 | Novel propellant-driven inhalation formulations:engineering polar drug particles with surface-trapped hydrofluoroalkane-philes显示文摘 | Wu L A1-Haydari M da Rocha SR | | 0，，02： | 1 |
| 17 | Endovascular treatment of acute traumatic thoracic aortic injuries:A retrospective analysis of 20 cases 显示文摘 | Urgnani F Lerut P Da Rocha M | 2009 | J Thorac Cardiovasc Surg2009，138，： | 1 |
| 18 | Mechanical and Rheological Properties of Composites Based on Polyolefin and Mineral Additives 显示文摘 | A L N da Silva M C G Rocha M A R Moraes | 2002 | Polymer Testing2002，，21： | 1 |
| 19 | Speciation of mercury using capillary electrophoresis coupled to volatile species generation - inductively coupled plasma mass spectrometry 显示文摘 | SILVA DA ROCHA M SOLDADO A B BLANCO E | 2001 | Journal of Analytical Atomic Spectrometry2001，16，9： | 1 |
| 20 | Advances in embryo culture systems显示文摘 | Smith G D da Rocha A M | | 0，，： | 1 |
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