维普期刊资源整合服务平台（V6.5）

维普中文期刊产品整合服务

5篇 您的检索式：作者名="S.Sherman"

选中清除导出查看参考文献查看引证文献引用追踪共1页首页上一页第1页下一页末页 /1 跳转

		题名	作者	年代	出处	被引量
	1	胰泌素刺激后3.0TMR表观扩散系数的测量显示文摘目的对有与没有慢性胰腺炎(CP)的病人进行3.0TMR胆胰管成像扩散加权(DW)扫描,前瞻性测量胰腺的表观扩散系数(ADC)。材料与方法研究由学术委员会批准并符合HIPAA法案。对预约行MR胆胰管成像的健康志愿者与怀疑和(或)已知有CP的病人均给予知情同意通知。所有受试者均行3.0TMR胆胰管成像,包括系列DWI序列(b=0、200、400s/mm2),给予胰泌素后15min采集数据。	M.F.Akisik K.Sandrasegaran S.G.Jennings A.M.Aisen S.Sherman 唐光健	2009	国际医学放射学杂志2009，32，5：	10
	2	Strategies for PET imaging of the receptor for advanced glycation endproducts(RAGE)显示文摘The implication of the receptor for advanced glycation end-products(RAGE)in numerous diseases and neurodegenerative disorders makes it interesting both as a therapeutic target and as an inflammatory biomarker.In the context of investigating RAGE as a biomarker,there is interest in developing radiotracers that will enable quantification of RAGE using positron emission tomography(PET)imaging.We have synthesized potential small molecule radiotracers for both the intracellular([18F]InRAGER)and extracellular([18F]RAGER)domains of RAGE.Herein we report preclinical evaluation of both using in vitro(lead panel screens)and in vivo(rodent and nonhuman primate PET imaging)methods.Both radiotracers have high affinity for RAGE and show good brain uptake,but suffer from off-target binding.The source of the off-target PET signal is not attributable to binding to melatonin receptors,but remains unexplained.We have also investigated use of lipopolysaccharide(LPS)-treated mice as a possible animal model with upregulated RAGE for evaluation of new imaging agents.Immunoreactivity of the mouse brain sections revealed increases in RAGE in the male cohorts,but no difference in the female groups.However,it proves challenging to quantify the changes in RAGE due to off-target binding of the radiotracers.Nevertheless,they are appropriate lead scaffolds for future development of 2nd generation RAGE PET radiotracers because of their high affinity for the receptor and good CNS penetration.	Lindsey R.Drake Allen F.Brooks Jenelle Stauff Phillip S.Sherman Janna Arteaga Robert A.Koeppe Aimee Reed Timothy J.Montavon Marc B.Skaddan Peter J.H.Scott	2020	Journal of Pharmaceutical Analysis2020，10，5：	2
	3	Collagen fibres in the wall of odontogenic keratocysts:a study with picrosirius red and polarizing microscopy显示文摘	Hirshberg A S.Sherman A.Buchner		0，，09：	1
	4	Use and perceived effectiveness of non‐analgesic medical therapies for chronic pancreatitis in the United States显示文摘	F.Burton S.Alkaade D.Collins V.Muddana A.Slivka R. E.Brand A.Gelrud P. A.Banks S.Sherman M. A.Anderson J.Romagnuolo C.Lawrence J.Baillie T. B.Gardner M. D.Lewis S. T.Amann J. G.Lieb M.O’Connell E. D.Kennard D.Yadav D. C.Whitcomb C. E.Forsmark	2010	Alimentary Pharmacology & Therapeutics2010，，1：	1
	5	Use and perceived effectiveness of non‐analgesic medical therapies for chronic pancreatitis in the United States显示文摘	F.Burton S.Alkaade D.Collins V.Muddana A.Slivka R. E.Brand A.Gelrud P. A.Banks S.Sherman M. A.Anderson J.Romagnuolo C.Lawrence J.Baillie T. B.Gardner M. D.Lewis S. T.Amann J. G.Lieb M.O’Connell E. D.Kennard D.Yadav D. C.Whitcomb C. E.Forsmark	2010	Alimentary Pharmacology & Therapeutics2010，，1：	1

返回顶部每页显示：

共1页首页上一页第1页下一页末页 /1 跳转

goolge学术搜索-维普

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费