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| 1 | Y-chromosome microdeletions in nonobstructive azoospermia and severe oligozoospermia显示文摘现在的工作的目的是介绍病人的结果, Y 染色体 microdeletions 由 intracytoplasmic 精子注射(ICSI ) 对待,任何一个用新鲜(TESE ) 或结冰融化(TESE-C ) 阴囊的精子和呼喊的精子(EJAC ) 。这个工作的创见居住在在 Y-microdeletions (AZFa, AZFb,和 AZFc ) 和治疗的不同类型之间的比较,与详细说明人口统计,刺激,胚胎学、临床、新生(NB ) 结果。有 Y-microdeletions 的 125 个病人, 33 个病人介绍了严重 oligozoospermia (有呼喊的精子的 18 执行 ICSI ) 和 92 能分泌的精子缺乏(65 与 40 去了 TESE 有成功的精子检索并且执行了 ICSI ) 。有 51 个 TESE 治疗周期和 43 个 TESE-C 治疗周期,与 19 NB 的出生(2 在 AZFa/TESE-C, 12 在 AZFc/TESE,并且 5 在 AZFc/TESE-C ) 。29 个 EJAC 周期,有 8 NB 的出生(在 AZFc ) 。在 TESE 和 EJAC 周期,在胚胎学、临床的参数没有重要差别。在 TESE-C 周期,在 AZFc 有重要更低的卵母细胞成熟率和更低的授精率。在结论,尽管有 AZFc microdeletions 的病人介绍了高阴囊的精子恢复率和可接受的临床的结果,有 AZFa 和 AZFb microdeletions 的盒子介绍了差的预后。由于 microdeletions 的报导遗传,病人们应该在 NB 和使用 preimplantation 的可能性上关于不肥沃的后果被通知为女性的基因诊断选择。 | Carolina Goncalves Mariana Cunha Eduardo Rocha Susana Fernandess, Joaquina Silva Luis Ferraz Cristiano Oliveira Alberto Barros Mairio Sousa | 2017 | Asian Journal of Andrology2017，19，3： | 5 |
| 2 | Siderophore-Producing Rhizobacteria as a Promising Tool for Empowering Plants to Cope with Iron Limitation in Saline Soils:A Review显示文摘Iron(Fe) bioavailability to plants is reduced in saline soils;however, the exact mechanisms underlying this effect are not yet completely understood. Siderophore-expressing rhizobacteria may represent a promising alternative to chemical fertilizers by simultaneously tackling salt-stress effects and Fe limitation in saline soils. In addition to draught, plants growing in arid soils face two other major challenges: high salinity and Fe deficiency. Salinity attenuates growth, affects plant physiology, and causes nutrient imbalance,which is, in fact, one of the major consequences of saline stress. Iron is a micronutrient essential for plant development, and it is required by several metalloenzymes involved in photosynthesis and respiration. Iron deficiency is associated with chlorosis and low crop productivity. The role of microbial siderophores in Fe supply to plants and the effect of plant growth-promoting rhizobacteria(PGPR) on the mitigation of saline stress in crop culture are well documented. However, the dual effect of siderophore-producing PGPR, both on salt stress and Fe limitation, is still poorly explored. This review provides a critical overview of the combined effects of Fe limitation and soil salinization as challenges to modern agriculture and intends to summarize some indirect evidence that argues in favour of siderophore-producing PGPR as biofertilization agents in salinized soils. Recent developments and future perspectives on the use of PGPR are discussed as clues to sustainable agricultural practices in the context of present and future climate change scenarios. | Maria J.FERREIRA Helena SILVA Angela CUNHA | 2019 | Pedosphere2019，29，4： | 3 |
| 3 | Dietary approach in the treatment of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) has been identified as one of the most prevalent chronic liver disease in adults and children populations. NAFLD is usually associated with the metabolic syndrome(MS), which is chiefly related to insulin resistance and its consequences. Insulin resistance has a crucial role in the pathogenesis of hepatic steatosis and potentially nonalcoholic steatohepatitis(NASH). Because of the contemporary epidemics of MS and obesity, the burden of NAFLD is also expected to rise. Unhealthy diets, such as the so-called western diet, are enriched in fructose, trans-fatty acids and saturated fat and seem to be associated with the development of NAFLD. In human studies, certain dietary sugars, particularly fructose, are used as a substrate for lipogenesis leading to hepatic fatty infiltration, inflammation, and possibly fibrosis. Other investigations have shown that fat consumption especially cholesterol and trans/saturated fatty acids are also steatogenic and seem to increase visceral adiposity. The identification of specific dietary components that favor the development of NASH could be important for the management of this disorder. This review focuses on the effects of different dietary approaches to prevent and treat NAFLD emphasizing the macronutrients and energy composition. | Silvia Marinho Ferolla Luciana Costa Silva Maria de Lourdes Abreu Ferrari Aloísio Sales da Cunha Flaviano dos Santos Martins Cláudia Alves Couto Teresa Cristina Abreu Ferrari | 2015 | World Journal of Hepatology2015，7，24： | 2 |
| 4 | Clinical hematological and biochemical parameters in Swiss,BALB/c,C57BL/6 and B6D2F1 Mus musculus显示文摘Background:Animal models are widely used in scientific research in order to obtain information from a whole organism under a specific set of experimental conditions.Various lineages of mice have been used to investigate diseases and new therapeutic strategies,and,consequently,hematological and biochemical tests in these laboratory animals are essential to validate scientific studies.Our study seeks to establish reference values for hematological and biochemical parameters of four lineages of mice.Methods:We evaluated the hematological and biochemical profiles of 20 males and 20 females from the lineages Swiss(heterogeneous),BALB/c and C57BL/6(isogenic),and B6D2F1(hybrid),totaling 160 mice.Analysis were standardized using the systems pocH-100iV Diff™for 19 hematological parameters and VITROS®350 for 12 biochemical parameters.Results:Results are shown as means and standard deviation,grouped by lineage and genre.Comparing the values obtained in this study with the values from previous studies,some variations were detected,which could be explained by differences in methodologies or individual variability.Conclusion:Thus our study shows that knowledge and disclosure of the values of physiological parameters of laboratory animals is necessary,and emphasises the importance of considering variations influenced by gender,lineage and genotype in the choice of the best experimental model. | Giorgio Silva-Santana Juliet Cunha Bax Débora Cristina Silva Fernandes Daniela Tendler Leibel Bacellar Cleber Hooper Alexandre Alves Souza Oliveira Dias Cristina Barbosa Silva Aline Moreira de Souza Simone Ramos Ricardo Alexandre Santos Thainara Ramos Pinto Mariana Antunes Ramão Ana Luíza Mattos-Guaraldi | 2020 | Animal Models and Experimental Medicine2020，3，4： | 2 |
| 5 | Nitric oxide is involved in control of trypansoma cruzi-induced parasitemia and directly kills the parasite in vitro显示文摘 | Glaucia NRV Cunha FQ and Silva JS | 1994 | Infection and Immunity1994，62，11： | 2 |
| 6 | 牙周炎和院内获得性肺炎之间的关联:观察性研究的系统评价和荟萃分析显示文摘目的:评估重症监护病房(ICU)患者的牙周炎与院内获得性肺炎之间的关联。材料和方法:本研究依据系统评价和荟萃分析的首选报告项目(PRISMA)的指南进行,并已在PROSPERO(国际前瞻性系统评价注册,英国约克大学)注册,注册号为CRD42018105124。本研究在五个数据库中进行了搜索,没有语言或出版日期的限制。在检索的560项研究中,对10篇进行了全文分析,其中五项病例对照研究符合条件,纳入荟萃分析。荟萃分析结果通过敏感性分析和异质性检验进行评价。通过比值比(OR)和95%置信区间计算简要效果量度。结果:在苔萃分析中.牙周炎与院内获得性肺炎之间存在显著相关性(OR 2.55,95%CI:1.68-3.86)。在此荟萃分析中,12=0%。结论:证据表明牙周炎与院内获得性肺炎之间呈正相关。与没有牙周炎的患者相比,入住ICU的牙周炎患者更容易出现院内获得性肺炎。 | Laura Silva Jeronimo Lucas Guimaraes Abreu Fabiano Araujo Cunha Rafael Paschoal Esteves Lima 程梦琳(译) 张珊珊(审) 郑树国(审) | 2020 | 中国口腔医学继续教育杂志2020，23，5： | 2 |
| 7 | Altering the time of the second gonadotropin-releasing hormone injection and artificial insemination(AI) during Ovsynch affects pregnancies per AI in lactating dairy cows显示文摘 | Brusveen DJ Cunha AP Silva CD | 2008 | Dairy Sei2008，91，3： | 1 |
| 8 | Insulin in W/O/W multiple emulsions: biological activity after administration in normal and diabetic rats 显示文摘 | Silva Cunha A Grossiord J L Puiseux F | 1997 | J Mierueneapsulatiun1997，14，： | 1 |
| 9 | Altering the time of the second gonadotropin-releasing hormone injection and artifi- cial insemination (AI)during Ovsyneh affects pregnancies per AI in lactating dairy cows显示文摘 | Brusveen D J Cunha A P Silva C D | 2008 | J Dairy Sci2008，91，3： | 1 |
| 10 | ErbB receptors and fatty acid synthase expression in aggressive head and neck squamous cell carcinomas 显示文摘 | Silva SD Cunha IW Younes RN | 2010 | Oral Dis2010，16，8： | 1 |
| 11 | Physico-chemical propert ies of endodontic sealers of different bases显示文摘 | Marín - Bauza GA Silva - Sousa YT da Cunha SA | | 0，，04： | 1 |
| 12 | Antibacterial activity of triterpene acids and semi-synthetic derivatives against oral pathogens显示文摘 | Scalon Cunha LC Andradee Silva ML Cardoso Furtado NA | 2007 | Z Naturfosch2007，62，910： | 1 |
| 13 | Semiconductor electrochemistry approach to passivity and stress corrosion cracking susceptibility of stainless steels显示文摘 | Rangel C M Silva T M Da Cunha Belo M | 2005 | Electrochimica acta2005，50，2526： | 1 |
| 14 | IgA,IgE and IgG subclasses to Candida albicans in serum and vaginal fluid from patients with vulvovaginal candidiasis显示文摘 | DE CARVALHO R J CUNHA C M SILVA D A | 2003 | Rev Assoc Med Bras2003，49，4： | 1 |
| 15 | In vitro trypanocidal activity of triterpenes from Miconia species显示文摘 | W R Cunha M Camila D da Silva Ferreira | | 0，，05： | 1 |
| 16 | Old game, new players: Linking classical theories to new trends in transplant immunology显示文摘The evolutionary emergence of an efficient immune system has a fundamental role in our survival against pathogenic attacks. Nevertheless, this same protective mechanism may also establish a negative consequence in the setting of disorders such as autoimmunity and transplant rejection. In light of the latter, although research has long uncovered main concepts of allogeneic recognition, immune rejection is still the main obstacle to long-term graft survival. Therefore, in order to define effective therapies that prolong graft viability, it is essential that we understand the underlying mediators and mechanisms that participate in transplant rejection. This multifaceted process is characterized by diverse cellular and humoral participants with innate and adaptive functions that can determine the type of rejection or promote graft acceptance. Although a number of mediators of graft recognition have been described in traditional immunology, recent studies indicate that defining rigid roles for certain immune cells and factors may be more complicated than originally conceived. Current research has also targeted specific cells and drugs that regulate immune activation and induce tolerance. This review will give a broad view of the most recent understanding of the allogeneic inflammatory/tolerogenic response and current insights into cellular and drug therapies that modulate immune activation that may prove to be useful in the induction of tolerance in the clinical setting. | Marina Burgos da Silva Flavia Franco da Cunha Fernanda Fernandes Terra Niels Olsen Saraiva Camara | 2017 | World Journal of Transplantation2017，7，1： | 1 |
| 17 | Histamine H2 Receptor Signaling in the Pathogenesis of Sepsis: Studies in a Murine Diabetes Model显示文摘 | Daniela Carlos Fernando Spiller Fabrício O. Souto Silvia C. Trevelin Vanessa F. Borges Andressa de Freitas José C. Alves-Filho Jo?o S. Silva Bernhard Ryffel Fernando Q. Cunha | 2013 | The Journal of Immunology2013，，3： | 1 |
| 18 | Presynaptic modulation con- trolling neuronal excitability and epileptogenesis:role of kain- ate,adenosine and neuropeptide Y receptors显示文摘 | Malva JO Silva AP Cunha RA | 2003 | Neurochem Res2003，28，10： | 1 |
| 19 | Actinic prurigo of the lip: Two case reports显示文摘Actinic prurigo is a photodermatosis that can affect the skin, conjunctiva and lips. It is caused by an abnormal reaction to sunlight and is more common in high-altitude living people, mainly in indigenous descendants. The diagnosis of actinic prurigo can be challenging, mainly when lip lesions are the only manifestation, which is not a common clinical presentation. The aim of this article is to report two cases of actinic prurigo showing only lip lesions. The patients were Afro-American and were unaware of possible Indian ancestry. Clinical exam, photographs, videoroscopy examination and biopsy were performed, and the diagnosis of actinic prurigo was established. Topical corticosteroid and lip balm with ultraviolet protection were prescribed with excellent results. The relevance of this report is to show that although some patients may not demonstrate the classical clinical presentation of actinic prurigo, the associated clinical and histological exams are determinants for the correct diagnosis and successful treatment of this disease. | Ana MO Miranda Thiago M Ferrari Juliana T Werneck Arley Silva Junior Karin S Cunha Eliane P Dias | 2014 | World Journal of Clinical Cases2014，2，8： | 1 |
| 20 | IgA, IgE and IgG snb- classe to candida albicans in serum and vagina fluid from pa- tients with vulvovaginal candidiasis 显示文摘 | Carvalho R J Cunha CM Silva DA | 2003 | Rev Assoc Med Bras2003，49，4： | 1 |
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