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| 1 | Coordinated silencing of the Sp1-mediated long noncoding RNA MEG3 by EZH2 and HDAC3 as a prognostic factor in pancreatic ductal adenocarcinoma显示文摘Objective:Pancreatic ductal adenocarcinoma(PDAC)is a disease with high mortality.Many so-called'junk'noncoding RNAs need to be discovered in PDAC.The purpose of this study was therefore to investigate the function and regulatory mechanism of the long noncoding RNA MEG3 in PDAC.Methods:The Gene Expression Omnibus database(GEO database)was used to determine the differential expression of long noncoding RNAs in PDAC,and MEG3 was selected for subsequent verification.Tissue and cell samples were used to verify MEG3 expression,followed by functional detection in vitro and in vivo.Microarrays were used to characterize long noncoding RNA and mRNA expression profiles.Competing endogenous RNA analyses were used to detect differential MEG3 and relational miRNA expression in PDAC.Finally,promoter analyses were conducted to explain the downregulation of MEG3 PDAC.Results:We generated a catalogue of PDAC-associated long noncoding RNAs in the GEO database.The ectopic expression of MEG3 inhibited PDAC growth and metastasis in vitro and in vivo,which was statistically significant(P<0.05).Microarray analysis showed that multiple microRNAs interacted with MEG3.We also showed that MEG3,as a competing endogenous RNA,directly sponged miR-374a-5p to regulate PTEN expression.The transcription factor,Sp1,recruited EZH2 and HDAC3 to the promoter and transcriptionally repressed MEG3 expression.Finally,clinical data showed that MEG3 and miR-374a-5p expressions were correlated with clinicopathological features.Statistically,Sp1,EZH2,HDAC3,and miR-374 a-5p were negatively correlated with MEG3(P<0.05).Conclusions:Reduced MEG3 levels played a crucial role in the PDAC malignant phenotype,which provided insight into novel and effective molecular targets of MEG3 for pancreatic cancer treatment. | Ting Han Meng Zhuo Cuncun Yuan Xiuying Xiao Jiujie Cui Guangrong Qin Liwei Wang Feng Jiao | 2020 | Cancer Biology & Medicine2020，17，4： | 3 |
| 2 | Elevated expression level of long noncoding RNA MALAT-1 facilitatescell growth, migration and invasion in pancreatic cancer显示文摘 | Feng Jiao Hai Hu Cuncun Yuan Lei Wang Weihua Jiang Ziliang Jin Zhen Guo Liwei Wang | 2014 | Oncology Reports2014，，6： | 2 |
| 3 | Molten salt as ultrastrong polar solvent enables the most straightforward pyrolysis towards highly efficient and stable single-atom electrocatalyst显示文摘Currently,pyrolysis as the most widely used method still has some key issues not well resolved for synthesis of carbon-supported single-atom catalysts(C-SACs),e.g.,the sintering of metal atoms at high temperature as well as the high cost and complicated preparations of precursors.In this report,molten salts are demonstrated to be marvellous medium for preparation of C-SACs by pyrolysis of small molecular precursors(ionic liquid).The ultrastrong polarity on one hand establishes robust interaction with precursor and enables better carbonization,resulting in largely enhanced yield.On the other hand,the aggregation of metal atoms is effectively refrained while no nanoparticle or cluster is formed.By this strategy,a C-SAC with atomically dispersed Fe-N_(4) sites and a high specific area over 2000 m^(2) g^(-1) is obtained,which illustrates high ORR activity in both acid and alkaline media.Moreover,this SAC exhibits superior methanol tolerance and stability after acid soaking at 85℃ for 48 h.It is believed that the molten-salts-assisted pyrolysis can be developed into a routine strategy as it not only can largely simply the synthesis of C-SACs,but also can be extended to prepare other types of SACs. | Nannan Li Wei Liu Chao Zhu Ce Hao Jingya Guo Hongyu Jing Jinwen Hu Cuncun Xin Danyang Wu Yantao Shi | 2021 | Journal of Energy Chemistry2021，30，3： | 1 |
| 4 | Hepatitis B virus polymerase impairs interferon‐α–induced STA T activation through inhibition of importin‐α5 and protein kinase C‐δ显示文摘 | Jieliang Chen Min Wu Xiaonan Zhang Wen Zhang Zhanqing Zhang Lixiang Chen Jing He Ye Zheng Cuncun Chen Fan Wang Yunwen Hu Xiaohui Zhou Cong Wang Yang Xu Mengji Lu Zhenghong Yuan | 2013 | Hepatology2013，，2： | 1 |
| 5 | Official Life: Homoerotic Self-Representation and Theater in Li Ciming's Yuemantang Riji显示文摘同性恋玩对从 mid-Qing 的看戏的娱乐文化中央到第二十个世纪的开始,特别在北京。看戏知识界特别地在精英,的生产和繁殖起了一个重要作用基于剧院的、同性恋再次培养,重重地在社会区别的追求投资自己。当不在北京歌剧的 popularisation 低估降低地位的观众的重要性是重要的时,知识界无疑地以两个认为自己是美学前卫上演戏剧的判断和在自己和男孩演员 offstage 之间的浪漫故事的文学提升。不同于在朋友之间传播了的花指南(Huapu ) ,从时期的日记在景色上记录私人想法不将,并且不能,在公共场合被表示。在有影响的 late-Qing 学者官员李次明( 183094 )的日记上绘画,我集中于公共参予的理解怎么进入了 Lis 日记的问题,以及检验他的自我表示不得不关于同性恋敏感和空格的 Qing 知识界所有权说的,它是说,他怎么并且怎么把他自己看作了介绍给其它(re-)那个自我演讲在他的写被介绍。 | Cuncun Wu | 2014 | Frontiers of History in China2014，9，2： | 0 |
| 6 | The Chinese herbal Formula Tongxieyaofang for irritable bowel syndrome:a protocol for meta-analysis of randomized controlled trials显示文摘背景:肠易激综合症(IBS)是一种慢性功能性肠病,以腹痛和肠功能改变为特征。通泻要方(TXYF)是一个长期用于治疗慢性腹泻腹痛的中药方剂,经常用于缓解IBS症状。虽然已经发表了一些关于它的研究,但对其作用效果还没有达成共识,并且最近又发表了新的相关研究。因此,需要系统评价和meta分析来评估中药通泻疗法治疗肠易激综合征的安全性和有效性。方法和分析:通过PubMed、EMBASE、Cochrane图书馆、CNKI、万方、VIP和CBM等数据库在没有日期和语言限制的情况下进行搜索。我们纳入随机对照试验将TXYF和另一种治疗IBS的方法进行对比。纳入研究的质量将在Cochrane手册5.1.0中使用偏倚风险工具进行独立评估,分类为偏倚风险低、不清楚或高。初级结果是主要症状消失和明显改善,二级结果包括直观类比标度(VAS)得分,不良事件,住院率和生活质量。荟萃分析将使用Cochrane的收集工具RevMan 5.3软件进行。结果:这项研究正在进行中,并将提交给同行评议的期刊发表。结论:本研究将为TXYF治疗IBS的安全性和有效性提供可靠证据。伦理与传播:由于本研究是基于文献的系统性评价和meta分析,因此不需要伦理审批和患者同意。这项研究的结果将提交给同行评议的期刊发表。 | Cuncun Lu Zhijiang Bi Kongyuan Wei Zhaochen Ji Long Ge Kehu Yang | 2018 | TMR Clinical Research2018，1，1： | 0 |
| 7 | A protocol for the reporting and methodological quality of robotic surgery case reports显示文摘背景:机器人手术是一种复杂且新兴的外科干预方法。近来机器人手术病例报告数量不断增加,但其报告和方法质量尚不清楚。方法:本文采用高特异度检索策略检索PubMed数据库去收集机器人手术相关病例报告,检索时间限定为2012年1月1日至2018年8月1日。用Microsoft Excel 2016生成随机数,并根据我们的纳入标准选择100个合适的机器人手术病例报告。采用数据提取表提取包括第一作者姓名,发表年份,期刊名称等信息。CARE指南和JBI检查表将被分别用于评价纳入病例报告的报告质量和方法学质量。数据提取和质量评价将由独立的两位作者完成,任何分歧将通过讨论或咨询第三个作者解决。同时将根据提取的信息进行分层分析。使用Review Manager 5.3软件(倒方差随机模型)合并与呈现分层分析的结果。结果:该项研究目前正在进行中,未来会将研究结果发表在同行评审的期刊上。结论:本研究将提供机器人手术病例报告的报告质量与方法学质量的证据,并为今后的病例报告提供借鉴与参考,但不仅限于机器人手术病例报告的报告。伦理与传播:由于本研究是基于已发表的机器人手术病例报告文献,因此,不需要伦理审查和患者知情同意。该研究结果将会提交给同行评审的期刊发表。 | Shuguo Niu Ming Liu Cuncun Lu Yuan Yuan Tingting Lu Long Ge Jinhui Tian | 2018 | TMR Clinical Research2018，1，2： | 0 |
| 8 | Sulfur production from smelter off-gas using CO–H2 gas mixture as the reducing agent over modified Fe/γ-Al2O3 catalysts显示文摘A series of modifiedγ-Al_2O_3supported iron-based catalysts(M-Fe/γ-Al_2O_3)was developed to reduce SO_2in actual smelter off-gases using CO–H_2gas mixture as reducing agent for sulfur production.Used as modifiers,three metal additives—Ni,Co,and Ce were added to Fe/γ-Al_2O_3catalysts.Changes in catalyst structure and active phase were characterized with X-ray diffraction,XPS,SEM,and EDS.The reduction ability of catalysts was exhibited via CO-TPR.The prepared catalysts only need to be pre-reacted for a period of time,eliminating the need for presulfidation treatment.Reaction conditions were optimized in a fixed bed reactor to achieve high SO_2conversion and sulfur selectivity.XRD characterization was carried out to verify the resulting sulfur products.Combining in situ infrared characterization and catalyst evaluation of support and active component,the reaction mechanism was investigated and proposed. | Tingting Ge Cuncun Zuo Lubin Wei Chunshan Li | 2018 | Chinese Journal of Chemical Engineering2018，26，9： | 0 |
| 9 | Tuning the bandgap of double perovskites显示文摘With great achievements in efficiency,stability,and large-scale preparation of perovskite solar cells(PSCs),the com-mercialization of PSC is ongoing,but there is still an issue on lead toxicity.Although lead content in the device is low,the water solubility of lead salts leads to potential environmental pollution.At present,the non-lead perovskites studied in-clude:divalent metal perovskite(e.g.,Sn^(2+),Ge^(2+),Cu^(2+)),trivalent metal perovskite(e.g.,Bi^(3+),Sb^(3+),In^(3+)),tetravalent met-al double perovskite(e.g.,Sn^(4+),Pd^(4+),Ti^(4+),Pt^(4+))and mono-trivalent mixed double perovskite(e.g.,Ag+and Bi^(3+),Ag+and In^(3+),Ag^(+)and Sb^(3+)).Their properties are summarized in Table 1.Since the first report on non-lead double perovskite Cs2AgBiBr6 in 2016^([1]). | Yu Zou Wenjin Yu Lixiu Zhang Cuncun Wu Lixin Xiao Liming Ding | 2021 | Journal of Semiconductors2021，42，12： | 0 |
| 10 | Asymmetrically ligated single atomic nickel sites for efficient hydrogen peroxide electrosynthesis显示文摘Atomic transition-metal-nitrogen-carbon electrocatalysts hold great promise as alternatives to benchmark Pt in the oxygen reduction reaction.The pristine metal centers with quasi square-planar D_(4h) configuration,however,still suffer from unfavorable energetics and thereby strong activity/selectivity trade-off during the catalytic process.Here we present a ligand-field engineering of single-atom Ni-N-C catalysts to boost the sluggish kinetics via rationally constructing prototypical asymmetrically ligated Ni-N_(3)O_(1) sites.The as-obtained Ni-supported multi-walled carbon nanotubes with molten salt-treated(defined as Ni/CNS)catalyst delivered an excellent H_(2)O_(2) selectivity(>90%)within a wide potential window(0.2–0.7 V vs.reversible hydrogen electrode(RHE))and robust stability(for 10 h)in alkaline medium.Combined electron paramagnetic resonance and theoretical analysis rationalize this finding and demonstrate that the broken symmetry facilitates the electron transfer of a σ* to O–O orbital as compared to the Ni-N_(4) counterpart,playing an indispensable role in efficient O_(2) activation. | Xusheng Cheng Jinwen Hu Wenzhe Shang Jingya Guo Cuncun Xin Songlin Zhang Suchan Song Wei Liu Yantao Shi | 2024 | Nano Research2024，17，3： | 0 |
| 11 | Pollutant exposure and health outcomes:protocol for a comprehensive umbrella review of meta-analyses and evidence mapping显示文摘Background:Many systematic reviews and meta-analyses(MAs)regarding the association between pollutant(e.g.,air pollution,noise pollution,and heavy metal pollution)exposure and health outcomes have been published recently,but there is still a lack of comprehensive research based on these MAs,and the evidence quality of these MAs are unknown.Therefore,we designed an umbrella review to address these gaps in knowledge.Methods:MAs that evaluated the association between pollutant exposure and health outcomes will be systematically searched through the PubMed and Embase databases in May 2021.Pairs of reviewers will conduct the study screening and data extraction independently,and cross-check the results.PRISMA and AMSTAR 2 will be used to evaluate the reporting and methodological quality of MAs included,respectively,and an evidence mapping method will be used to present the results.The corrected cover area(CCA)method will be used to assess the degree of overlap for included primary studies among MAs.The outcomes will be reanalyzed based on the random-effects model using the appropriate effect size,and the corresponding 95%confidence intervals will be reported.Meanwhile,sensitivity analysis and subgroup analysis will be used to explore heterogeneity.The GRADE method will be used to evaluate the evidence quality of outcome indicators.Stata 16.0 and Excel 2019 will be used for data analysis,and P<0.05 will be considered to indicate statistical significance.Results:The results of this umbrella review will be submitted to a peer-reviewed English journal for publication.Conclusion:We designed the first umbrella review to summarize evidence from MAs on the association between common pollutant exposure and health conditions.The results of this study will provide evidence for health policy makers to formulate appropriate health policies and researchers to conduct new studies. | Jing Qi Lufang Feng Jiemei Hu Haitong Zhao Jieyun Li Lixin Ke Xue Shang Kehu Yang Cuncun Lu | 2021 | Asian Toxicology Tesearch2021，3，3： | 0 |
| 12 | Interannual variations in salt flux at 80°E section of the equatorial Indian Ocean显示文摘The interannual variations in salt flux on the 80°E section in the equatorial Indian Ocean were explored based on the ORAS5 data,which was quite consistent with the observational data among the four available reanalysis datasets.The results indicated that the area with significant interannual variations in salt flux coincided with that of significant climatological mean salt flux in general and was mainly located in the upper 150 m layer.Specifically,three important areas were identified in the north-south direction,i.e.,(1)the Equatorial Indian Ocean Area(EIOA,3°S–3°N),where the mean salt flux was eastward with the largest value on the section and associated with the most significant interannual variations mainly modulated by the Wyrtki Jets and the Equatorial Undercurrent;(2)the South Equatorial Indian Ocean Area(SEIOA,3°S–6°S),where the mean salt flux changed in the vertical direction from strong eastward flux in the upper layer to weak westward flux in the subsurface layer and associated with significant interannual variations in the upper 100 m layer,which was affected by the South Equatorial Countercurrent;and(3)the North Equatorial Indian Ocean Area(NEIOA,3°N–6°N),where the mean salt flux changed in the north-south direction from strong westward flux to the north of 5°N to weak eastward flux in the south and associated with relatively significant interannual variations,which was mainly influenced by the South Sri Lanka Coastal Current.Two leading interannual variation modes were revealed by the empirical orthogonal function decomposition.The first mode accounted for 39%of the total variance and had four significant spatial antinodes;two of those in-phase antinodes were located at SEIOA and upper 75 m of EIOA,and the other two opposite in-phase antinodes were located at NEIOA and below 75 m of EIOA.The second mode accounted for 17%of the total variance having four antinodes with two dominant out-of-phase antinodes located at the subsurface of EIOA and SEIOA.The temporal components of the two leading modes showed a 1–4 year variation with a main period of 2 years,in which the first mode showed a greater correlation with the Indian Ocean Dipole,while the second mode showed a weak correlation with the Indian Ocean Dipole and the El Niño-Southern Oscillation.Variance analysis showed that the interannual variations in salt flux were mainly determined by the variations in the current,and the spatial distribution was modulated by temporal mean salinity.Composite strong interannual events showed interannual variations in current,and so the salt flux was driven by the interannual anomaly of the wind field and sea surface temperature associated with the Indian Ocean Dipole. | Cuncun XIE Ruibin DING Jiliang XUAN Daji HUANG | 2023 | Science China Earth Sciences2023，66，9： | 0 |
| 13 | Management of Perioperative Target Blood Pressure in Bridging Therapy for Acute Ischemic Stroke显示文摘Objective:To investigate the management of perioperative target blood pressure in the treatment of acute ischemic stroke with intravenous thrombolytic bridging.Methods:Retrospective analysis of the blood pressure management and nursing experience of 36 patients with acute ischemic stroke who received endovascular treatment with bridge mode from November 2017 to January 2019 in our hospital.Through correct monitoring of basic blood pressure,rapid and stable blood pressure reduction before the bridge treatment,close cooperation during the operation,and close observation and treatment of postoperative blood pressure fluctuations,the patient’s blood pressure can be controlled within the target range.Results:The blood vessels of 36 patients were partially or completely recanalized after treatment.Clinical outcomes:Two cases died.After 90 days,29 patients with good clinical outcomes were followed up,and 5 patients with poor clinical prognosis.Conclusion:Effective blood pressure management is a necessary measure in the perioperative period of bridging therapy for patients with acute ischemic stroke,which can reduce the postoperative complications of patients treated with bridging therapy,obtain good therapeutic effect and improve the prognosis of patients. | Lin Zhu Qinghong Wang Cuncun Liu | 2019 | Journal of Clinical and Nursing Research2019，3，2： | 0 |
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