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| 1 | Targets and molecular mechanisms of triptolide in cancer therapy显示文摘Triptolide(TPL/TL) is a natural drug with novel anticancer effects. Preclinical studies indicated that TPL inhibits cell proliferation, induces cell apoptosis, inhibits tumor metastasis and enhances the effect of other therapeutic methods in various cancer cell lines. Multiple molecules and signaling pathways, such as caspases, heat-shock proteins, NF-κB, and deoxyribonucleic acid(DNA) repair-associated factors, are associated with the anti-cancer effect. TPL also improves chemoradiosensitivity in cancer therapy. Phase I trials indicate the potential clinical value of TPL use. However, further trials with larger sample sizes are needed to confirm these results. | Cuicui Meng Hongcheng Zhu Hongmei Song Zhongming Wang Guanhong Huang Defan Li Zhaoming Ma Jianhua Ma Qin Qin Xinchen Sun Jianxin Ma | 2014 | Chinese Journal of Cancer Research2014，26，5： | 16 |
| 2 | Caking property and active components of coal based on group component separation显示文摘The content and the caking index of the heavy,the dense medium and the loose medium components of coal,obtained by extraction and stripping with CS_2/N-methyl-2-pyrrolidinone mixed solvent(1:1 by volume),were studied and correlated with the caking property of raw coals.Images of the three group components after heat treatment were analyzed.The results show that both caking index(G) and maximum thickness of plastic layer(Y) of coals have a good linear relationship with the content of the medium component;the dense medium and the loose medium components are the two key factors to determine the caking property of raw coals-they are the source materials of fluidity and swelling of coal,respectively;the heavy component without the swelling and fluidity was cohered by the other components;two new indexes,which can extend current understanding of the caking properties,were introduced. | Qin Zhihong Li Xiang Sun Hui Zhao Cuicui Rong Liman | 2016 | International Journal of Mining Science and Technology2016，26，4： | 6 |
| 3 | Recent advances in lentiviral vectors for gene therapy显示文摘Lentiviral vectors(LVs), derived from human immunodeficiency virus, are powerful tools for modifying the genes of eukaryotic cells such as hematopoietic stem cells and neural cells. With the extensive and in-depth studies on this gene therapy vehicle over the past two decades, LVs have been widely used in both research and clinical trials. For instance, third-generation and selfinactive LVs have been used to introduce a gene with therapeutic potential into the host genome and achieve targeted delivery into specific tissue. When LVs are employed in leukemia, the transduced T cells recognize and kill the tumor B cells;in β-thalassemia, the transduced CD34^(+) cells express normal β-globin;in adenosine deaminase-deficient severe combined immunodeficiency, the autologous CD34^(+) cells express adenosine deaminase and realize immune reconstitution. Overall, LVs can perform significant roles in the treatment of primary immunodeficiency diseases, hemoglobinopathies, B cell leukemia, and neurodegenerative diseases. In this review, we discuss the recent developments and therapeutic applications of LVs. The safe and efficient LVs show great promise as a tool for human gene therapy. | Xiaoyu Wang Cuicui Ma Roberto Rodríguez Labrada Zhou Qin Ting Xu Zhiyao He Yuquan Wei | 2021 | Science China(Life Sciences)2021，64，11： | 4 |
| 4 | Bevacizumab promotes active biological behaviors of human umbilical vein endothelial cells by activating TG Fpi pathways via off-VEGF signaling显示文摘Objective:Bevacizumab is a recombinant humanized monoclonal antibody that blocks vascular endothelial growth factor(VEGF)with clear clinical benefits.However,overall survival of some cancer types remains low owing to resistance to bevacizumab therapy.While resistance is commonly ascribed to tumor cell invasion induced by hypoxia-inducible factor(HIF),less attention has been paid to the potential involvement of endothelial cells(ECs)in vasculature activated by anti-angiogenic drugs.Methods:Human umbilical vein ECs(HUVECs),bEnd.3 cells,and mouse retinal microvascular ECs(MRMECs)were treated with bevacizumab under conditions of hypoxia and effects on biological behaviors,such as migration and tube formation,examined.Regulatory effects on TGFpi and CD 105(endoglin)were established via determination o f protein and mRNA levels.We further investigated whether the effects of bevacizumab could be reversed using the receptor tyrosine kinase inhibitor anlotinib.Results:Bevacizumab upregulated TGFpi as well as CD 105,a component o f the TGFP receptor complex and an angiogenesis promoter.Elevated CD 105 induced activation of Sm adl/5,the inflammatory pathway and endothelial-mesenchymal transition.The migration ability of HUVECs was enhanced by bevacizumab under hypoxia.Upregulation o f CD 105 was abrogated by anlotinib,which targets multiple receptor tyrosine kinases including VEGFR2/3,FGFR1-4,PD G FRα/β,C-Kit,and RET.Conclusions:Bevacizumab promotes migration and tube formation of HUVECs via activation of the TGFβi pathway and upregulation of CD105 expression.Anlotinib reverses the effects of bevacizumab by inhibiting the above signals. | Xiaoling Zhang Yan Zhang Yanan Jia Tingting Qin Cuicui Zhang Yueya Li Chengmou Huang Zhujun Liu Jing Wang Kai Li | 2020 | Cancer Biology & Medicine2020，17，2： | 3 |
| 5 | An actively ultrafast tunable giant slow-light effect in ultrathin nonlinear metasurfaces显示文摘A slow-light effect based on metamaterial-induced transparency(MIT)possesses great practical applications for integrated photonic devices.However,to date,only very weak slow-light effects have been obtained in metamaterials because of the intrinsic loss of metal.Moreover,no active control of slow-light has been achieved in metamaterials.Here,we report the realization of a giant slow-light effect on an ultrathin metasurface that consists of periodic arrays of gold nanoprism dimers with a thickness of 40 nm sandwiched between a multilayer-graphene micro-sheet/zinc oxide nanoparticle layer and a monolayer graphene/polycrystalline indium tin oxide layer.The strong field confinement of the plasmonic modes associated with the MIT ensures a tremendous reduction in the group velocity around the transparency window.A group index of more than 4×10^(3) is achieved,which is one order of magnitude greater than that of previous reports.A large tunable wavelength range of 120 nm is achieved around the center of the transparency window when the pump light intensity is only 1.5 kW cm^(-2).The response time is as fast as 42.3 ps.These results demonstrate the potential for the realization of various functional integrated photonic devices based on metasurfaces,such as all-optical buffers and all-optical switches. | Cuicui Lu Xiaoyong Hu Kebin Shi Qin Hu Rui Zhu Hong Yang Qihuang Gong | 2015 | Light(Science & Applications)2015，4，1： | 3 |
| 6 | Pretreatment of wastewater from acrylonitrile–butadiene–styrene (ABS) resin manufacturing by microelectrolysis显示文摘 | Bo Lai Yuexi Zhou Hongke Qin Changyong Wu Cuicui Pang Yu Lian Jixian Xu | 2011 | Chemical Engineering Journal2011，，： | 1 |
| 7 | Evolution of drug regulations and regulatory innovation for anticancer drugs in China显示文摘Over the past two decades,China has introduced significant changes to drug regulations through regulatory innovations to accelerate drug review and approvals,keeping in line with the rapidly growing scientific innovation in drug research and development(R&D).In this study,we outlined the revolution of drug regulation in China since the establishment of the State Drug Administration in 1998.More particularly,we performed a comprehensive analysis of newly approved anticancer drugs in China from the year 2005 to May 2021,as a powerful illustration of how the revolution has changed the drug R&D landscape.Innovative drug development in China has boomed,benefiting in particular from pro-innovation policies as well as expedited program designations by the authority.We found a significant increase in the number of both imported and domestic new anticancer drugs from 2005 to 2021,with the emergence of drugs with novel mechanisms of action,including immune checkpoint inhibitors and cell therapy products.Drug lag has also been dramatically shortened by more than 70%for imported drugs in years 2016-2020 compared to years 2006-2010.Furthermore,we provide an insight into the potential approaches to further optimize the science-based and clinical value-based regulatory and R&D drug ecosystem in China.This review provides evidence of significant impacts of regulations and policies on drug R&D and suggests that the constantly adapting regulatory ecosystem will speed up drug development in China and worldwide. | Yang Liu Ning Zhang Cuicui Xie Yale Jiang Yunhe Qin Liyun Zhou Yi Fan Lianjie Ren Chen Yin Huan Yang Wei Xie Qing Zhai Guanqiao Li Hongzhuan Chen Xiaoyuan Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 1 |
| 8 | Up-regulation of CXCR4 in rat umbilical mesenchymal stem cells induced by serum from rat with acute liver failure promotes stem cells migration to injured liver tissue显示文摘 | Changqing Deng Ailan Qin Weifeng Zhao Tingting Feng Cuicui Shi Tao Liu | 2014 | Molecular and Cellular Biochemistry . 2014 (1-2)2014，，1： | 1 |
| 9 | Pretreatment of wastewater from acrylonitrile–butadiene–styrene (ABS) resin manufacturing by microelectrolysis显示文摘 | Bo Lai Yuexi Zhou Hongke Qin Changyong Wu Cuicui Pang Yu Lian Jixian Xu | 2011 | Chemical Engineering Journal2011，，： | 1 |
| 10 | Assessment and Optimization Strategies of Campus Sound Environment显示文摘A good sound environment is essential in creating a harmonious and peaceful campus,improving students’learning outcomes,promoting physical and mental health,and creating a green and healthy campus.This study investigated the impact of new buildings on existing ones by optimizing the spacing between new buildings and the sound insulation structure of building enclosures.The results indicated that building 4 was affected by the noise from new building 1 and its surroundings,with a maximum outdoor daytime noise level reaching 69 dB,and the indoor background noise level in the least favorable classroom was 43.73 dB,less than 45 dB,which was within the acceptable range.It is recommended that the sound insulation design be improved in the planning of new teaching buildings.Besides,the surrounding traffic conditions should be improved,and the usage time of sports facilities should be scheduled appropriately to prevent the noise from sporting activities from affecting the classroom activities.The findings of this study provide valuable references for future architectural acoustics design and campus planning,contributing to the creation of peaceful and comfortable campus environments. | Cuicui Qin Qiliang Yu Wei Zhang | 2023 | Journal of World Architecture2023，7，6： | 0 |
| 11 | Analysis of the Architectural Design Talent Development Direction by Investigating the Employment Status of Architectural Design Graduates显示文摘Based on a comprehensive investigation of the employment status of architectural design graduates at a certain university,this paper analyzes the correctness of the talent development direction of architectural design in hopes of pro-viding a valuable reference for further teaching reform and strengthening school-enterprise collaboration.The research re-sults show that architectural design is the main choice of graduates,accounting for as high as 63%,and traditional architec-tural design skills continue to be in demand in the market.Employment in fields such as interior design,BIM design,and green architecture is also included.The distribution of job positions for graduates is mainly in the areas of scheme design assistants and construction drawing design,requiring software operation,communication,scheme design,and construction drawing skills.This paper also proposes talent development measures such as optimizing the curriculum,strengthening faculty construction,and deepening school-enterprise collaboration,in order to improve the quality of talent development and the competitiveness of graduates. | Cuicui Qin Lijuan Xie Qiliang Yu Guanhong Chen Binquan Zhang Yani Gao | 2023 | Journal of Architectural Research and Development2023，7，6： | 0 |
| 12 | Simulation Evaluation of Outdoor Noise Environment in Buildings显示文摘Green campus design has become an essential strategy to enhance campus life and learning.However,noise pol-lution remains a troubling aspect that impacts teaching and learning processes,even causing harm to the health of students and teachers.Therefore,acoustic environment quality design is crucial.This article focuses on the expansion project of a school campus in Shenzhen.We simulated and analyzed the outdoor noise environment separately for the proposed teach-ing building,as well as the existing buildings like the dining hall,teaching building,and laboratory building.The results showed that the proposed teaching building was mainly affected by surrounding noise,with the worst outdoor noise being in classrooms adjacent to the teaching building in the south and the basketball court at the west of the classroom,with maximum noise values reaching 73 dB and 66 dB,respectively.In the future,these rooms should be renovated to achieve an excellent indoor soundproof environment. | Cuicui Qin Qiliang Yu Wenyu Zou | 2023 | Journal of Architectural Research and Development2023，7，6： | 0 |
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