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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Clinical classification of symptomatic heterotopic pancreas of the stomach and duodenum:A case series and systematic literature review显示文摘BACKGROUND Heterotopic pancreas(HP)is an aberrant anatomic malformation that occurs most commonly in the upper gastrointestinal tract.While the majority of heterotopic pancreatic lesions are asymptomatic,many manifest severe clinical symptoms which require surgical or endoscopic intervention.Understanding of the clinical manifestations and symptoms of HP is limited due to the lack of large volume studies in the literature.The purpose of this study is to review symptomatic cases at a single center and compare these to a systematic review of the literature in order to characterize common clinical manifestations and treatment of this disease.AIM To classify the common clinical manifestations of heterotopic pancreas.METHODS A retrospective review was conducted of pathologic samples containing heterotopic pancreas from 2000-2018.Review was limited to HP of the upper gastrointestinal tract due to the frequency of presentation in this location.Symptomatic patients were identified from review of the medical records and clinical symptoms were tabulated.These were compared to a systematic review of the literature utilizing Pub Med and Embase searches for papers pertaining to heterotopic pancreas.Publications describing symptomatic presentation of HP were selected for review.Information including demographics,symptoms,presentation and treatment were compiled and analyzed.RESULTS Twenty-nine patient were identified with HP at a single center,with six of these identified has having clinical symptoms.Clinical manifestations included,gastrointestinal bleeding,gastric ulceration with/without perforation,pancreatitis,and gastric outlet obstruction.Systemic review of the literature yielded 232 publications detailing symptomatic cases with only 20 studies describing ten or more patients.Single and multi-patient studies were combined to form a cohort of 934 symptomatic patients.The majority of patients presented with abdominal pain(67%)combined with one of the following clinical categories:(1)Dyspepsia,(n=445,48%);(2)Pancreatitis(n=260,28%);(3)Gastrointestinal bleeding(n=80,9%);and(4)Gastric outlet obstruction(n=80,9%).The majority of cases(n=832,90%)underwent surgical or endoscopic resection with 85%reporting resolution or improvement in their symptoms.CONCLUSION Heterotopic pancreas can cause significant clinical symptoms in the upper gastrointestinal tract.Better understanding and classification of this disease may result in more accurate identification and treatment of this malformation. | Michael T Le Compte Brandon Mason Keenan J Robbins Motoyo Yano Deyali Chatterjee Ryan C Fields Steven M Strasberg William G Hawkins | 2022 | World Journal of Gastroenterology2022，28，14： | 3 |
| 3 | Modeling cardiac arrest and resuscitation in the domestic pig显示文摘Cardiac arrest remains a leading cause of death and permanent disability worldwide. Although many victims are initially resuscitated, they often succumb to the extensive ischemia-reperfusion injury inflicted on the internal organs, especially the brain. Cardiac arrest initiates a complex cellular injury cascade encompassing reactive oxygen and nitrogen species, Ca2+ overload, ATP depletion, pro- and anti-apoptotic proteins, mitochondrial dysfunction, and neuronal glutamate excitotoxity, which injures and kills cells, compromises function of internal organs and ignites a destructive systemic inflammatory response. The sheer complexity and scope of this cascade challenges the development of experimental models of and effective treatments for cardiac arrest. Many experimental animal preparations have been developed to decipher the mechanisms of damage to vital internal organs following cardiac arrest and cardiopulmonary resuscitation(CPR), and to develop treatments to interrupt the lethal injury cascades. Porcine models of cardiac arrest and resuscitation offer several important advantages over other species, and outcomes in this large animal are readily translated to the clinical setting. This review summarizes porcine cardiac arrest-CPR models reported in the literature, describes clinically relevant phenomena observed during cardiac arrest and resuscitation in pigs, and discusses numerous methodological considerations in modeling cardiac arrest/CPR. Collectively, published reports show the domestic pig to be a suitable large animal model of cardiac arrest which is responsive to CPR, defibrillatory countershocks and medications, and yields extensive information to foster advances in clinical treatment of cardiac arrest. | Brandon H Cherry Anh Q Nguyen Roger A Hollrah Albert H Olivencia-Yurvati Robert T Mallet | 2015 | World Journal of Critical Care Medicine2015，4，1： | 2 |
| 4 | Hydrocompression settlement of deep fills 显示文摘 | Brandon T L Duncan J M Gardner W S | 1990 | ASCE Journal of Geotech Eng1990，116，10： | 1 |
| 5 | Expression of rabbit interleukin-4 and characterization of its biologic activity on T and Bcells显示文摘 | Brandon T Wesley C Van Voorhis | 2006 | Veterinary Immunol and Immuno Pathol2006，113，3： | 1 |
| 6 | Probability Density Plot for Fission-Track Gra-in Age Samples显示文摘 | Brandon M T | 1996 | Radiation Measurements1996，26，5： | 1 |
| 7 | Laser and electron beam welding of SiCp reinforced aluminum A-356 metal matrix composites显示文摘 | Lienert T J Brandon E D and Lippold J C | 1993 | Scripta Metallurgica et Materialia1993，28，11： | 1 |
| 8 | On steady states in mountain belts 显示文摘 | Willett S D Brandon M T | 2002 | Geology2002，30，2： | 1 |
| 9 | Modelling of cells,stacks and systems based around metal-supported planar IT-SOFC cells with CGO electrolytes operating at 500 ~ 600 ℃显示文摘 | LEAH R T BRANDON N P AGUIAR P | 2005 | Power Sources2005，145，2： | 1 |
| 10 | Two apolipoprotein E mimetic peptides, ApoE (130-149) and ApoE (141-155) 2, bind to LRPI显示文摘 | Croy JE Brandon T Komives EA | 2004 | Biochemistry2004，43，23： | 1 |
| 11 | Modeling of ceils, stacks and systems based around metal-supported planar IT-SOFC cells with CGO electrolytes operating at 500-600显示文摘 | Leah R T Brandon N P Aguiar P | 2005 | Journal of Power Sources2005，145，2： | 1 |
| 12 | How erosion builds mountains显示文摘 | PINTER N BRANDON M T | 1997 | Scientific American1997，276，： | 1 |
| 13 | Decomposition of mixed grain age distributions using Binomfit 显示文摘 | Brandon M T | 2002 | On Track2002，24，： | 1 |
| 14 | Com- parison of plasticity in vivo and in vitro in the developing vi- sual cortex of normal and protein kinase A RI/3-deficient mice显示文摘 | HENSCH T K GORDON J A BRANDON E P | 1998 | The Journal of Neuroscience1998，18，6： | 1 |
| 15 | Erosional denudation of the British Columbia coast Ranges as determination from fission-track ages of detrital zirconfrom the Tofino basin, Olympic Peninsula, Washington显示文摘 | Brandon M T | 1994 | GeologicalSociety of America Bulletin1994，106，： | 1 |
| 16 | Fundamentals of detrital zircon fission-track analysis for provenance and exhumation studies with examples from the European Alps 显示文摘 | Bemet M Brandon M T Garver J I | 2004 | Geological Society of America Special Papers2004，378，： | 1 |
| 17 | Shaping development of autophagy in hibitors with the structure of the lipid kinase Vps34显示文摘 | Simon M Brandon T Arkadiusz O | 2010 | Science2010，327，5973： | 1 |
| 18 | Genetic and environmental influences on blood pressure and pulse pressure among adult African Americans显示文摘 | BRANDON D T WHITWELD K E SOLLERS J J 3rd | 2003 | Ethn Dis2003，13，： | 1 |
| 19 | Tectonic Evolution of the Cenozoic Olympic Subduction Complex,Washing- ton State, as Deduced from Fission Track Ages for Detrital Zircons 显示文摘 | BRANDON M T VANCE J A | 1992 | American Journal of Science1992，292，： | 1 |
| 20 | Using thermochronology to understand orogenic erosion显示文摘 | Reiners P W Brandon M T | 2006 | Annual Review of Earth and Planetary Sciences2006，34，： | 1 |
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