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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | Use of Luminex xMAP derived Bio-Plex bead based suspension array for specific detection of PPV W and characterization of epitopes on the coat protein of the virus显示文摘 | Croft H Malinowski T Krizbai L | 2008 | J Virol Methods2008，153，2： | 1 |
| 3 | The applicability of empiri- cal vegetation indices for determining leaf chlorophyU con- tent over different leaf and canopy structures显示文摘 | Croft H Chen J M Zhang Y | 2014 | Ecologi- cal Complexity2014，17，1： | 1 |
| 4 | Effects of vitamin C and vitamin E on in vivo lipid peroxidation : results of a randomized controlled trial 显示文摘 | Huang H Y Appel L J Croft K D | 2002 | Am J Clin Nutr2002，76，3： | 1 |
| 5 | Primaquine-loaded poly (lactide) nanoparticules: physicochemical study and acutetolerancein mice显示文摘 | Rodrigues J M Croft S L Fessi H | 1995 | Int J Pharm1995，126，： | 1 |
| 6 | Exact Ray Calculation in A Quasi-Parabolic Ionosphere with No Magnetic Field 显示文摘 | Croft A T Hoogasian H | 1968 | Radio Science1968，3，1： | 1 |
| 7 | White blood cell count: independent predictor of coronary, heart disease mortality among a national cohort 显示文摘 | Brown D W Giles W H Croft J B | 2001 | J Clin Epidemiol2001，54，3： | 1 |
| 8 | Characterizing soil surface roughness using a combined structural and spectral approach显示文摘 | Croft H Anderson K Kuhn N J | 2009 | European Journal of Soil Science2009，60，3： | 1 |
| 9 | Modelling leaf chlorophyll content in broadleaf and needle leaf canopies from ground, CASI, Landsat TM 5 and MERIS reflectance data显示文摘 | Croft H Chen J M Zhang Y | 2013 | Remote Sensing of Environment2013，133，： | 1 |
| 10 | Effects of vitamin C and vitamin E on in vivo lipid peroxidation: results of a randomized controlled trial 显示文摘 | Huang H Y Appel L J Croft K D | 2002 | Am J Clin Nutr2002，76，： | 1 |
| 11 | The United Kingdom public health re- sponse to an imported laboratory confirmed case of a no- vel coronavirus in September 2012显示文摘 | Pebody R G Chand M A Thomas H L Green H K Boddington N L Carvalho C Brown C S Anderson S R Rooney C Crawley-Boevey E Irwin D J Aarons E Tong C Newsholme W Price N Langrish C Tucker D Zhao H Phin N Crofts J Bermingham A Gil- gunn-Jones E Brown K E Evans B Catchpole M Watson J M | 2012 | Euro Surveill2012，17，20： | 1 |
| 12 | Effects of vitamin C and vitamin E on in vivo lipid peroxidation:results of a randomized controlled trial显示文摘 | HUANG H Y APPEL L J CROFT K D | 2002 | Am J Clin Nutr2002，76，： | 1 |
| 13 | Use of Luminex xMAP-derived Bio-Plex bead-based suspension array for specific detection of PPV W and characterization of epitopes on the coat protein of the virus显示文摘 | Croft H Malinowski T Krizbai L | 2008 | Journal of Virological Methods2008，153，2： | 1 |
| 14 | White blood cell count:an independent predictor of coronary heart disease mortality among a national cohort 显示文摘 | BROWN D W GILES W H CROFT J B | 2001 | J Clin Epidemiol2001，54，3： | 1 |
| 15 | White blood cell count:an independent predictor of coronary heart disease mortality among a national cohort显示文摘 | Brown DW Giles W H Croft J B | 2001 | J Clin Epidemiol2001，54，31： | 1 |
| 16 | Effect on body weight of bupropion sustained-release in patients with major depression treated for 52 weeks显示文摘 | Croft H Houser TL Jamerson BD | 2002 | Clin Ther2002，24，4： | 1 |
| 17 | Modelling leaf chlorophyll content in broadleaf and needle leaf canopies from ground, CASI, Landsat TM 5 and MERIS reflectance data显示文摘 | Croft H Chen J M Zhang Y | 2013 | Remote Sensing of Environment2013，133，6： | 1 |
| 18 | Individual risk factors for hip osteoarthritis: obesity, hip injury, and physical activity 显示文摘 | COOPER C INSKIP H CROFT P | 1998 | Am J Epidemiol1998，147，6： | 1 |
| 19 | Subband image coding using watershed and watercourse lines of the wavelet transform显示文摘 | Croft L H John A R | 1994 | IEEE Trans on Image Processing1994，3，6： | 1 |
| 20 | Chemical chaperoning action of glycerol on the antifreeze protein of rainbow smelt显示文摘 | Gong H Croft K Driedzic W R | 2011 | Journal of Thermal Biology2011，36，1： | 1 |
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