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43篇 您的检索式：作者名="Crispi F"

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	题名	作者	年代	出处	被引量
1	SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases.	Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera	2020	Signal Transduction and Targeted Therapy2020，5，1：	7
2	Gestational age-and estimated fetal weight-adjusted reference ranges for myocardial tissue Doppler indices at 24-41 weeks'gestation显示文摘	Comas M Crispi F Gómez O	2011	Ultrasound Obstet Gynecol2011，37，1：	1
3	Assisted Reproductive Technologies Are Associated With Cardiovascular Remodeling In Utero That Persists Postnatally显示文摘	Brenda Valenzuela-Alcaraz Fàtima Crispi Bart Bijnens Monica Cruz-Lemini Montserrat Creus Marta Sitges Joaquim Bartrons Salvadora Civico Juan Balasch Eduard Gratacós	2013	Circulation2013，，13：	1
4	Contribution of the myocardial performance index and aortic isthmus blood flow index to predicting mortality in preterm growth-restricted fetuses显示文摘	Hernandez-Andrade E F Crispi	2009	Ultrasound Obstet Gynecol2009，34，4：	1
5	Placental angiogenic growth fac- tors and uterine artery Doppler findings for characterization of different subsets in preeclampsia and in isolated intrauterine growth restriction 显示文摘	Crispi F Dominguez C Llurba E	2006	Am J Obstet Gynecol2006，195，：	1
6	Cytoskeletal Changes in the Hippocampus Following Restraint Stress:Role of Serotonin and Microtubules显示文摘	Bianchi M Heidbreder C Crispi F	2003	Synapse2003，49，3：	1
7	Predictive value of angiogenic factors and uterine artery Doppler for early-versus lateonset pre-eclampsia and intrauterine growth restriction显示文摘	Crispi F Llurba E Dominguez C		0，，03：	1
8	Placental angiogenic growth factors and uterine artery Doppler findings for characterization of different subsets in preeclampsia and in isolated intrauterine growth restriction显示文摘	Crispi F Dominguez C Llurba E	2006	Am J Obstet Gynecol2006，，：	1
9	Cardiac dysfunction and cell damage across clinical stages of severity in growth-restricted fetuses显示文摘	Crispi F Hernandez-Andrade E Pelsers MM	2008	Am J Obstet Gyneco12008，199，3：	1
10	Assessment of fetal cardiac function using tissue Doppler techniques显示文摘	Comas M Crispi F	2012	Fetal Diagnosis and Therapy2012，32，1：	1
11	Predictive value of angiogenie factors and uterine artery Doppler for early-versus late-onset preeclampsia and intrauterine growth restriction 显示文摘	Crispi F Llurba E Dominguez C	2008	Ultrasound Obstet Gynecol2008，31，：	1
12	Update on the Pathophysi- ological Implications and Clinical Role of Angiogenic Fac- tors in Pregnancy显示文摘	Llurba E Crispi F Verlohren S	2015	Fetal Diagn Ther2015，，2：	1
13	Placental angiogenic growth factors and uterine artery Doppler findings for characterization of different subsets in preeclampsia and in isolated intrauterine growth restriction显示文摘	Fàtima Crispi Carmen Domínguez Elisa Llurba Pilar Martín-Gallán Luís Cabero Eduard Gratacós	2006	American Journal of Obstetrics and Gynecology2006，，：	1
14	Assessment of fetal cardiac function using tissue Doppler techniques 显示文摘	Comas M Crispi F	2012	Fetal Diagn Ther2012，32，12：	1
15	Predictive value of angiogenic factors and uterine artery Doppler for early versuslate-onset pre-eclampsia and intrauterine growth restriction 显示文摘	Crispi F Llurba E Dominguez C	2008	Ultrasound Obstet Gynecol2008，31，3：	1
16	Placental angiogenigrowth factors and uterine artery Doppler findings for eharacteization of different subsets in preeelampsia and in isolated intrauterine growth restriction显示文摘	Crispi F Dominguez C Llurba E	2006	Am J Obstet Gynecol2006，，：	1
17	Risk of perinatal death in early-onset intrauterine growth restriction according to gestational age and cardiovascular Doppler indices:a multicenter study显示文摘	Cruz-Lemini M Crispi F Van Mieghem T	2012	Fetal Diagn Ther2012，32，12：	1
18	Fetal growth restriction results in remodeled and less efficient hearts in children 显示文摘	Crispi F Bijnens 8 Figueras F	2010	Circulation2010，121，22：	1
19	Assessment of fetal cardiac function using tissue Doppler techniques显示文摘	Comas M Crispi F	2012	Fetal Diagn Ther2012，32，12：	1
20	A computational model of the fetal circulation to quantify blood redistribution in intrauterine growth restriction显示文摘	Garcia-Canadilla P Rudenick PA Crispi F	2014	PLoS Comput Biol2014，10，10：	1

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