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| 1 | Statin use and cognitive function in middle-aged adults with type 1 diabetes显示文摘AIM To test associations between statin use and cognitive impairment in adults with childhood-onset type 1 diabetes(T1D).METHODS In 2010-13, n = 108 middle-aged participants from ongoing observational Pittsburgh Epidemiology of Diabetes Complications Study underwent neurocognitive assessment(mean age and T1 D duration of 49 and 41 years, respectively). All were diagnosed with childhoodonset(i.e., prior to age 18) T1 D between 1950 and 1980 and were seen within one year of diagnosis at Children's Hospital of Pittsburgh. Self-reported statin use(yes/no and if yes, name of statin) was collected biennially from parent study baseline(1986-1988) to time of neurocognitive testing. Logistic regression models tested associations between statin use groups and cognitive impairment(defined as having two or more cognitive test scores 1.5SD or worse than published norms) while linear regression models tested associations between statin use groups and cognitive domain z-scores(domains: Verbal IQ, memory, executive function, psychomotor speed, and visuo-construction). All models controlled for education and age. To address confounding by indication, models were repeated using a propensity score for statin use.RESULTS Of the 108 participants, 51 reported never using statins. Median duration of statin use among the 57 ever users was 6 years. These 57 ever statin users were split to create two groups(≤ or > median years of statin use): 1-6 years(n = 25), and 7-12 years(n = 32). Compared with never users, using statins 1-6 years tripled the odds of cognitive impairment(OR = 3.16; 95%CI: 0.93-10.72; P = 0.06) and using statins 7-12 years almost quintupled the odds of cognitive impairment(OR = 4.84; 95%CI: 1.63-14.44; P = 0.005). Compared with never users, using statins 1-6 or 7-12 years was related to worse performance in the memory domain(β =-0.52; P = 0.003, and-0.39; P = 0.014, respectively). Adjusting for coronary artery disease, low density lipoprotein cholesterol, and Apo E4 status did not substantially alter results, and none of these covariates were significantly related to cognitive outcomes(all P > 0.05). Propensity score analyses support that associations between poor cognitive outcomes and statin use were not due merely to confounding by indication. CONCLUSION Statin use was associated with cognitive impairment, particularly affecting memory, in these middle-aged adults with childhood-onset T1 D, whom at this age, should not yet manifest age-related memory deficits. | Karen A Nunley Trevor J Orchard Christopher M Ryan Rachel Miller Tina Costacou Caterina Rosano | 2017 | World Journal of Diabetes2017，8，6： | 2 |
| 2 | Lower-extremity arterial calcification as a correlate of coronary artery calcification显示文摘 | Costacou T Huskey ND Edmundowicz D | 2006 | Metabolism2006，55，12： | 1 |
| 3 | Plasma and dietary vita-min E in relation to incidence of type 2 diabetes:The Insulin Re-sistance and Atherosclerosis Study(IRAS)显示文摘 | Mayer-Davis EJ Costacou T King I | 2002 | Diabetes Care2002，25，12： | 1 |
| 4 | The 30-year natural history of type 1 diabetes complications:the Pittsburgh Epidemi- ology of Diabetes Complications Study experience显示文摘 | Pambianco G Costacou T Ellis D | 2006 | Diabetes2006，55，5： | 1 |
| 5 | Plasma and dietary vitamin E in relation to incidence of type 2 diabetes: the insulin resistance and atherosclerosis study (IRAS) 显示文摘 | MAYER - DAVIS E J COSTACOU T KING I | 2002 | Diabetes Care2002，25，： | 1 |
| 6 | A very simple empirical kinetic model of the acidcatalyzed cure of urea-formaldehyde resins 显示文摘 | CARVALHO L M H COSTA M R PF N COSTAC A V | 2006 | Journal of Applied Polymer Science2006，102，6： | 1 |
| 7 | Association of socioe- conomic status with mortality in type 1 diabetes: the Pittsburgh epidemiology of diabetes complications study 显示文摘 | Secrest AM Costacou T Gutelius B | 2011 | Ann Epidemi- ol2011，21，5： | 1 |
| 8 | Clinical factors associated with resistance io microvascular complications in diabetic patients of extreme disease duration: the 50- year medalist study 显示文摘 | Keenan HA Costacou T Sun JK | 2007 | Diabetes Care2007，30，8： | 1 |
| 9 | Plasma and dietary vitamin E in relation to incidence of type 2 diabetes: The Insulin Resistance and Atherosclerosis Study (IRAS) 显示文摘 | MAYER-DAVIS E J COSTACOU T KING I | 2002 | Diabetes Care2002，25，： | 1 |
| 10 | Adiposity and mortality in type 1 diabetes 显示文摘 | Conway B Miller RG Costacou T | 2009 | Int J Obes (Lond)2009，33，7： | 1 |
| 11 | The 30-year natural history of type 1 diabetes complications:the Pittsburgh Epidemiology of Diabetes Complications Study experience显示文摘 | PAMBIANCO G COSTACOU T ELLIS D | 2006 | Diabetes2006，55，5： | 1 |
| 12 | Postpartum adiponeetin concentration, insulin resistance and metabolic abnormalities among women with pregnancy-induced disturbances 显示文摘 | Costacou T Bosnyak Z Harger GF | 2008 | Prey Cardiol2008，11，2： | 1 |
| 13 | Analysisof raw meatto predict proteolysis in Parma ham显示文摘 | Schivazappaa C Degnib M Nanni Costac L | 2002 | Meat Science2002，60，： | 1 |
| 14 | Haptoglobin geno- type: a determinant of cardiovascular complication risk in type I diabetes显示文摘 | Costacou T Ferrell RE Orchard TJ | 2008 | Diabetes2008，57，： | 1 |
| 15 | Lower-extremity arterial calcification as a correlate of coronary artery calcification显示文摘 | Costacou T Huskey ND Edmundowicz D | 2006 | Metabolism2006，55，14： | 1 |
| 16 | Adiposity and mortality in type 1 diabetes 显示文摘 | Conway B Miller RG Costacou T | 2009 | International Journal of Obesity2009，33，7： | 1 |
| 17 | Nutrition and prevention of Type 2 diabetes显示文摘 | Costacou T Mayer-Davis E J | 2003 | Ann Rev Nutr2003，23，： | 1 |
| 18 | Clinical factors associated with resistance to microvascular complications in diabetic patients of extreme disease duration显示文摘 | Keenan HA Costacou T Sun JK Doria A Cavellerano J Coney J | 2007 | Diabetes Care2007，30，8： | 1 |
| 19 | Sleep and cognitive(memory) function:research and clinical perspectives显示文摘 | Roth T Costac e Slilva JA Chase MH | | 0，，05： | 1 |
| 20 | Adherence to a Mediterranean diet and survival in a Greek population 显示文摘 | Trichopoulou A Costacou T Bamia C | 2003 | New Engl J Med2003，348，26： | 1 |
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