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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | 剪切下交联研究显示文摘研究剪切下交联情况 ,将交联过程描述为 4个连续阶段 ,最后一阶段得到均匀分散的微凝胶颗粒。低毒交联体系(聚丙烯酰胺共聚物 /Al3 + )的实验结果证明 ,交联剂浓度、pH值、流变仪狭缝大小和剪切速率等因素对交联时间和凝胶的最终剪切黏度等理化性能都有影响 ,通过控制合适的剪切条件 ,可以制备新型分散凝胶体系。图 4参 2 (胡菁华摘 ) | 胡菁华 刘玉章 白宝君 李良雄 Coste Jean Paul | 2002 | 石油勘探与开发2002，29，4： | 10 |
| 3 | 活性氧化铝除氟研究显示文摘针对目前活性氧化铝饮水除氟中存在的问题,进行了生产性试验研究,通过采用原水投加CO_2气体降低pH值、小颗粒活性氧化铝、大流量短历时的NaOH循环再生法等新技术,提高了活性氧化铝的吸附容量和处理水的能力,克服滤料板结和假疲劳,除氟效果稳定可靠,水质好,再生时间短,用药省,降低了基建投资和运转费用。 | North China Municipal Engineering Design Institute A full-scale plant was set up for studying the existing problems on the fluoride removal from drinking water by activated alumina. Some new methods was adopted,such as the addition of CO2to reduce water pH value,the use of small-sized activated alumina,and the employment of a cyclic regeneration at large flow rate with NaOH as regenerant,which result in the improvement of adsorption capacity of activated alumina and treatment capacity, the elimination of the hardening of filtration materials and false fatigue,stable and reliable effectiveness,good quality in water,short regeneration time,small consumption of regenerant. And then the capital and openational costs were reduced. | 1989 | 中国给水排水1989，5，3： | 5 |
| 4 | 完善铁路工程造价标准体系 夯实铁路建设投资控制基础显示文摘回顾铁路工程造价标准体系形成过程,阐述按照'建设前期、工程交易期、工程实施期'三阶段实现铁路工程全过程造价管理的主要内容,分析'编制办法开放稳定,工程定额动态管理,价格信息及时发布,前期后期有机衔接'是完善铁路工程造价标准体系的关键,为实现铁路建设投资有效控制打好基础。 | Engineering Cost Department of Economic and Planning Institute of Ministry of Railways | 2007 | 铁道经济研究2007，，4： | 4 |
| 5 | Apple whole genome sequences:recent advances and new prospects显示文摘In 2010,a major scientific milestone was achieved for tree fruit crops:publication of the first draft whole genome sequence(WGS)for apple(Malus domestica).This WGS,v1.0,was valuable as the initial reference for sequence information,fine mapping,gene discovery,variant discovery,and tool development.A new,high quality apple WGS,GDDH13 v1.1,was released in 2017 and now serves as the reference genome for apple.Over the past decade,these apple WGSs have had an enormous impact on our understanding of apple biological functioning,trait physiology and inheritance,leading to practical applications for improving this highly valued crop.Causal gene identities for phenotypes of fundamental and practical interest can today be discovered much more rapidly.Genome-wide polymorphisms at high genetic resolution are screened efficiently over hundreds to thousands of individuals with new insights into genetic relationships and pedigrees.High-density genetic maps are constructed efficiently and quantitative trait loci for valuable traits are readily associated with positional candidate genes and/or converted into diagnostic tests for breeders.We understand the species,geographical,and genomic origins of domesticated apple more precisely,as well as its relationship to wild relatives.The WGS has turbo-charged application of these classical research steps to crop improvement and drives innovative methods to achieve more durable,environmentally sound,productive,and consumer-desirable apple production.This review includes examples of basic and practical breakthroughs and challenges in using the apple WGSs.Recommendations for“what’s next”focus on necessary upgrades to the genome sequence data pool,as well as for use of the data,to reach new frontiers in genomics-based scientific understanding of apple. | Cameron P.Peace Luca Bianco Michela Troggio Eric van de Weg Nicholas P.Howard Amandine Cornille Charles-Eric Durel Sean Myles ZoëMigicovsky Robert J.Schaffer Evelyne Costes Gennaro Fazio Hisayo Yamane Steve van Nocker Chris Gottschalk Fabrizio Costa David Chagné Xinzhong Zhang Andrea Patocchi Susan E.Gardiner Craig Hardner Satish Kumar Francois Laurens Etienne Bucher Dorrie Main Sook Jung Stijn Vanderzande | 2019 | Horticulture Research2019，6，1： | 3 |
| 6 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 7 | Tuberosity malposition and migration: Reasons for poor outcomes after hemiarthroplasty for displaced fractures of the proximal humerus显示文摘 | P Boileau S.G Krishnan L Tinsi G Walch J.S Coste D Molé | 2002 | Journal of Shoulder and Elbow Surgery2002，，5： | 2 |
| 8 | IL-6 and IGF-1 are Independent Prognostic Factors of Liver Steatosis and Non-Alcoholic Steatohepatitis in Morbidly Obese Patients显示文摘 | David García-Galiano Miguel A. Sánchez-Garrido Isabel Espejo José Luis Montero Guadalupe Costán Trinidad Marchal Antonio Membrives José M. Gallardo-Valverde Juan R. Mu?oz-Casta?eda Eugenio Arévalo Manuel Mata Jordi Muntané | 2007 | Obesity Surgery2007，，： | 2 |
| 9 | Ombitasvir/paritaprevir/ritonavir + dasabuvir +/-ribavirin in real world hepatitis C patients显示文摘BACKGROUND The hepatitis C virus(HCV) NS5A inhibitor ABT-267(ombitasvir, OBV), the HCV NS4/4A protease inhibitor ABT-450(paritaprevir, PTV), the CYP3A inhibitor ritonavir(r) and the non-nucleoside NS5B polymerase inhibitor ABT-333(dasabuvir, DSV)(OBV/PTV/r + DSV) with or without ribavirin(RBV) is a direct-acting antiviral regimen approved in the United States and other major countries for the treatment of HCV in genotype 1(GT1) infected patients. Patients with HCV who are considered 'hard-to-cure' have generally been excluded from registration trials due to rigorous study inclusion criteria, presence of comorbidities and previous treatment failures.AIM To investigate the efficacy of this regimen in HCV G1-infected patients historically excluded from clinical trials.METHODS Patients were ≥ 18 years old and chronically infected with HCV GT1(GT1a, GT1b or GT1a/1b). Patients were treatment-na?ve or previously failed a regimen including pegylated interferon/RBV +/-telaprevir, boceprevir, or simeprevir.One hundred patients were treated with the study drug regimen, which was administered for 12 or 24 wk +/-RBV according to GT1 subtype and presence/absence of cirrhosis. Patients were evaluated every 4 wk from treatment day 1 and at 4 and 12 wk after end-of-treatment.RESULTS Many of the patients studied had comorbidities(44.2% hypertensive, 33.7%obese, 20.2% cirrhotic) and 16% previously failed HCV treatment. Ninety-six patients completed study follow-up and 99% achieved 12-wk sustained virologic response. The majority(88.4%) of patients had undetectable HCV RNA by week 4. The most common adverse events were fatigue(12%), headache(10%),insomnia(9%) and diarrhea(8%); none led to treatment discontinuation. Physical and mental patient reported outcomes scores significantly improved after treatment. Almost all(98%) patients were treatment compliant.CONCLUSION In an all-comers HCV GT1 population, 12 or 24-wk of OBV/PTV/r + DSV +/-RBV is highly effective and tolerable and results in better mental and physical health following treatment. | Nicole Loo Eric Lawitz Naim Alkhouri Jennifer Wells Carmen Landaverde Angie Coste Rossalynn Salcido Michael Scott Fred Poordad | 2019 | World Journal of Gastroenterology2019，25，18： | 2 |
| 10 | Tool-life and wear mechanisms of CBN tools in machining of Inconel 718显示文摘 | J.P. Costes Y. Guillet G. Poulachon M. Dessoly | 2006 | International Journal of Machine Tools and Manufacture2006，，7： | 2 |
| 11 | Age and race differences in racial stereotype awareness and endorsement显示文摘 | Kristine E. Copping Beth Kurtz‐Costes Stephanie J. Rowley Dana Wood | 2013 | J Appl Soc Psychol2013，，5： | 2 |
| 12 | Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle显示文摘 | Carles Cantó Lake Q. Jiang Atul S. Deshmukh Chikage Mataki Agnes Coste Marie Lagouge Juleen R. Zierath Johan Auwerx | 2010 | Cell Metabolism2010，，3： | 2 |
| 13 | Left ventricular aneurysm:a new surgical approach显示文摘 | Saab M Coste P | 1989 | Thorac Cardiovasc Surg1989，37，1： | 1 |
| 14 | Experimental study on demineralized bone matrix and coral as bone graft substitutes in maxillofacial surgery显示文摘 | Dupoirieux L Costes V Jammet P | 1994 | Int J Oral Maxillofac Surg1994，23，14： | 1 |
| 15 | Use of recombinant adenovirus for metabolic engineering of mammalian cells显示文摘 | Beeker T C Noel R J Costs W S | 1994 | Methods Cell Biol1994，43，： | 1 |
| 16 | Supplementing desflurane remifentanil anesthesia with small-dose ketamine reduces perioperative opioid analgegic requirements显示文摘 | Guignard B Coste C Costes H | 2002 | Anesth Analg2002，95，： | 1 |
| 17 | Knockout rats via embryo microinjection of zlnc-finger nucleases 显示文摘 | Geurts AM Cost GJ Freyvert Y | 2009 | Science2009，325，5939： | 1 |
| 18 | Piezol and Piezo2 are es- sential components of distinct mechanically activated cation channels显示文摘 | Coste B Mathur J Schmidt M | 2010 | Science2010，330，6000： | 1 |
| 19 | Stomatal regulation of photosynthesis in apple leaves: evidence for different water-use strategies between two euhivars显示文摘 | Massonnet C Costes E Rambal S Dreyer E Regnard J L | 2007 | Annals of Botany2007，100，6： | 1 |
| 20 | Seasonal succession of dia- toms and Chlorophyceae in the drainage network of the Seine River:observations and modeling显示文摘 | Gamier J Billen G Coste M | | 0，，： | 1 |
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