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| 1 | Targeting mast cells in gastric cancer with special reference to bone metastases显示文摘Bone metastases from gastric cancer(GC) are considered a relatively uncommon finding; however, they are related to poorer prognosis. Both primary GC and its metastatic progression rely on angiogenesis. Several lines of evidence from GC patients strongly support the involvement of mast cells(MCs) positive to tryptase(MCPT) in primary gastric tumor angiogenesis. Recently,we analyzed infiltrating MCs and neovascularization in bone tissue metastases from primary GC patients, and observed a significant correlation between infiltrating MCPT and angiogenesis. Such a finding suggested the involvement of peritumoral MCPT by infiltrating surrounding tumor cells, and in bone metastasis angiogenesis from primary GC. Thus, an MCPT-stimulated angiogenic process could support the development of metastases in bone tissue. From this perspective, we aim to review the hypothetical involvement of tumorinfiltrating,peritumoral MCPT in angiogenesis-mediated GC cell growth in the bone microenvironment and in tumor-induced osteoclastic bone resorption. We also focus on the potential use of MCPT targeting agents,such as MCs tryptase inhibitors(gabexate mesylate,nafamostat mesylate) or c-KitR tyrosine kinase inhibitors(imatinib, masitinib), as possible new anti-angiogenic and anti-resorptive strategies for the treatment of GC patientsaffected by bone metastases. | Christian Leporini Michele Ammendola Ilaria Marech Giuseppe Sammarco Rosario Sacco Cosmo Damiano Gadaleta Caroline Oakley Emilio Russo Giovambattista De Sarro Girolamo Ranieri | 2015 | World Journal of Gastroenterology2015，21，37： | 5 |
| 2 | Potential role of Limosilactobacillus fermentum as a probiotic with anti-diabetic properties: A review显示文摘Oxidative stress,inflammation,and gut microbiota impairments have been implicated in the development and maintenance of diabetes mellitus.Strategies capable of recovering the community of commensal gut microbiota and controlling diabetes mellitus have increased in recent years.Some lactobacilli strains have an antioxidant and anti-inflammatory system capable of protecting against oxidative stress,inflammation,and diabetes mellitus.Experimental studies and some clinical trials have demonstrated that Limosilactobacillus fermentum strains can beneficially modulate the host antioxidant and anti-inflammatory system,resulting in the amelioration of glucose homeostasis in diabetic conditions.This review presents and discusses the currently available studies on the identification of Limosilactobacillus fermentum strains with anti-diabetic properties,their sources,range of dosage,and the intervention time in experiments with animals and clinical trials.This review strives to serve as a relevant and well-cataloged reference of Limosilactobacillus fermentum strains capable of inducing anti-diabetic effects and promoting health benefits. | Diego Cabral Lacerda Paulo César Trindade da Costa Paula Brielle Pontes Lucas Alves Carneiro dos Santos JoséPatrocínio Ribeiro Cruz Neto Cristiane Cosmo Silva Luis Vanessa Polyana de Sousa Brito JoséLuiz de Brito Alves | 2022 | World Journal of Diabetes2022，13，9： | 3 |
| 3 | Pharmacokinetic-based total intravenous anaesthesia using remifentanil and propofol for surgical myocardial revascularization 显示文摘 | Guarracino F Penzo D De Cosmo D | 2003 | Eur J Anaesthesiol2003，20，5： | 1 |
| 4 | Design of process parameters for dual phase steel production with strip rolling using the finite-element method显示文摘 | De Cosmo M Galantucci L M Tricarico L | 1999 | Journal of Materials Processing Technology1999，9293，： | 1 |
| 5 | Haemodynamic and metabolic changes during major liver resection with age of hepatic total vascular exclusion显示文摘 | De Cosmo GA Adducci E Gualtieri EM | 2000 | Int Surg2000，85，3： | 1 |
| 6 | Pharmacokinetic -based total intravenous anaesthesia using remifentanil and propofol for surgical myocardial revascularization显示文摘 | Guarracino F Penzo D De Cosmo D | 2003 | Eur J Anaesthesiol2003，20，5： | 1 |
| 7 | Ropivacaine vs levobpivacaine combinedwith sufentanil for epidural analgesia after lung surgery显示文摘 | De Cosmo G Congedo E Lai C | 2008 | Eur J Anaesthesiol2008，25，12： | 1 |
| 8 | Haemodynamic and metabolic changes during major liver resection with use of hepatic total vascular exclusion显示文摘 | De Cosmo GA Adducci E Gualtieri EM | | 0，，： | 1 |
| 9 | Identification of TSH receptor mutations in three families with resistance to TSH显示文摘 | Tonacchera M Di Cosmo C De Marco G | | 0，，： | 1 |
| 10 | Haemody- namic and metabolic changes during major liver resection with use of hepatic total vascular exclusion显示文摘 | De Cosmo GA Adducci E Gualtieri EM | 2000 | Int Surg2000，85，： | 1 |
| 11 | PPAR72 P12Apolymorphism and albuminuria in patients with type 2 diabetes : ameta-analysis of case-control studies 显示文摘 | De Cosmo S Prodente S Lamacchia O | 2011 | Diabetes2011，26，12： | 1 |
| 12 | Sedation in PACU: the role of propofol 显示文摘 | De Cosmo G Congedo E Clemente A | 2005 | Curr Drug Targets2005，6，7： | 1 |
| 13 | Extraparenchymal Control of Hepatic Veins During Mesohepatectomy显示文摘 | Felice Giuliante Gennaro Nuzzo Francesco Ardito Maria Vellone Germano De Cosmo Ivo Giovannini | 2008 | Journal of the American College of Surgeons2008，，3： | 1 |
| 14 | Sea surface wind stress and drag coefficients: The hexos results显示文摘 | Stuart D. Smith Robert J. Anderson Wiebe A. Oost C. Kraan Nico Maat Janice De Cosmo Kristina B. Katsaros Kenneth L. Davidson Karl Bumke Lutz Hasse Helen M. Chadwick | 1992 | Boundary - Layer Meteorology (-)1992，，1： | 1 |
| 15 | Analgesia in Tho- racic Surgery: Review显示文摘 | De Cosmo G Aceto P Gualtieri E | 2009 | Minerva Anestesiol2009，75，6： | 1 |
| 16 | Design of process parameters for dual steel production with strip rolling using the finite-element method 显示文摘 | Cosmo M De Galantucci L M Tricarico L | 1999 | Journal of Materials Processing Technology1999，9293，： | 1 |
| 17 | New drugs for epidural analgesia显示文摘 | Congedo E Sgreccia M De Cosmo G | 2009 | Curr Drug Targets2009，10，8： | 1 |
| 18 | Design of process parameters for dual phase steel production with strip rolling using the finite-element method 显示文摘 | Cosmo De M Galantucci L M Tricarico L | 1999 | Journal of Materials Processing Technology1999，9293，： | 1 |
| 19 | Analgesia in tho raeic surgery: review 显示文摘 | De Cosmo G Aceto P Gualtieri E | 2009 | Minerva Anestesiol2009，75，6： | 1 |
| 20 | ENPP1 gene, insulin resistance and related clinical outcomes 显示文摘 | Bacci S De Cosmo S Prudente S | 2007 | Curr Opin Clin Nutr Metab Care2007，10，4： | 1 |
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