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| 1 | The pig as a preclinical traumatic brain injury model:current models,functional outcome measures,and translational detection strategies显示文摘Traumatic brain injury(TBI) is a major contributor of long-term disability and a leading cause of death worldwide. A series of secondary injury cascades can contribute to cell death, tissue loss, and ultimately to the development of functional impairments. However, there are currently no effective therapeutic interventions that improve brain outcomes following TBI. As a result, a number of experimental TBI models have been developed to recapitulate TBI injury mechanisms and to test the efficacy of potential therapeutics. The pig model has recently come to the forefront as the pig brain is closer in size, structure, and composition to the human brain compared to traditional rodent models, making it an ideal large animal model to study TBI pathophysiology and functional outcomes. This review will focus on the shared characteristics between humans and pigs that make them ideal for modeling TBI and will review the three most common pig TBI models–the diffuse axonal injury, the controlled cortical impact, and the fluid percussion models. It will also review current advances in functional outcome assessment measures and other non-invasive, translational TBI detection and measurement tools like biomarker analysis and magnetic resonance imaging. The use of pigs as TBI models and the continued development and improvement of translational assessment modalities have made significant contributions to unraveling the complex cascade of TBI sequela and provide an important means to study potential clinically relevant therapeutic interventions. | Holly A.Kinder Emily W.Baker Franklin D.West | 2019 | Neural Regeneration Research2019，14，3： | 7 |
| 2 | 睾丸扭转误诊后导致男性不育及勃起功能障碍(英文)显示文摘睾丸扭转在25岁以下的男性中其发病率约为1/4 000,其高发人群为新生儿和进入青春期的青少年。睾丸扭转的误诊率为4%,非同期的双侧睾丸扭转被误诊的发病率没有报导。本文报道1例由于双侧睾丸扭转误诊后导致的睾丸功能衰竭、性腺功能低下及勃起功能障碍。患者在睾丸扭转10年后才因不育和勃起功能障碍就诊,精液分析检查为无精症,血清中的睾酮水平降低到去势的水平(0.14 nmol/L)。其不育为永久性,其勃起功能经睾酮替代和使用西地那非后得以恢复。 | Brett W.Baker John K.Surratt 王润 | 2005 | 中华男科学杂志2005，11，8： | 5 |
| 3 | Identification of predictive MRI and functional biomarkers in a pediatric piglet traumatic brain injury model显示文摘Traumatic brain injury(TBI) at a young age can lead to the development of long-term functional impairments. Severity of injury is well demonstrated to have a strong influence on the extent of functional impairments;however, identification of specific magnetic resonance imaging(MRI) biomarkers that are most reflective of injury severity and functional prognosis remain elusive. Therefore, the objective of this study was to utilize advanced statistical approaches to identify clinically relevant MRI biomarkers and predict functional outcomes using MRI metrics in a translational large animal piglet TBI model. TBI was induced via controlled cortical impact and multiparametric MRI was performed at 24 hours and 12 weeks post-TBI using T1-weighted, T2-weighted, T2-weighted fluid attenuated inversion recovery, diffusion-weighted imaging, and diffusion tensor imaging. Changes in spatiotemporal gait parameters were also assessed using an automated gait mat at 24 hours and 12 weeks post-TBI. Principal component analysis was performed to determine the MRI metrics and spatiotemporal gait parameters that explain the largest sources of variation within the datasets. We found that linear combinations of lesion size and midline shift acquired using T2-weighted imaging explained most of the variability of the data at both 24 hours and 12 weeks post-TBI. In addition, linear combinations of velocity, cadence, and stride length were found to explain most of the gait data variability at 24 hours and 12 weeks post-TBI. Linear regression analysis was performed to determine if MRI metrics are predictive of changes in gait. We found that both lesion size and midline shift are significantly correlated with decreases in stride and step length. These results from this study provide an important first step at identifying relevant MRI and functional biomarkers that are predictive of functional outcomes in a clinically relevant piglet TBI model. This study was approved by the University of Georgia Institutional Animal Care and Use Committee(AUP: A2015 11-001) on December 22, 2015. | Hongzhi Wang Emily W.Baker Abhyuday Mandal Ramana M.Pidaparti Franklin D.West Holly A.Kinder | 2021 | Neural Regeneration Research2021，16，2： | 4 |
| 4 | Spectral shape, epsilon and record selection显示文摘 | Jack W.Baker C.Allin Cornell | 2006 | Earthquake Engng. Struct. Dyn2006，，9： | 2 |
| 5 | Spectral shape, epsilon and record selection显示文摘 | Jack W.Baker C.Allin Cornell | 2006 | Earthquake Engng Struct Dyn2006，，9： | 2 |
| 6 | A vector‐valued ground motion intensity measure consisting of spectral acceleration and epsilon显示文摘 | Jack W.Baker C.Allin Cornell | 2005 | Earthquake Engng Struct Dyn2005，，10： | 2 |
| 7 | A vector‐valued ground motion intensity measure consisting of spectral acceleration and epsilon显示文摘 | Jack W.Baker C.Allin Cornell | 2005 | Earthquake Engng. Struct. Dyn2005，，10： | 1 |
| 8 | A vector‐valued ground motion intensity measure consisting of spectral acceleration and epsilon显示文摘 | Jack W.Baker C.Allin Cornell | 2005 | Earthquake Engng Struct Dyn2005，，10： | 1 |
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