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| 1 | Voxel-based magnetic resonance imaging investigation of poor and preserved clinical insight in people with schizophrenia显示文摘AIM To define regional grey-matter abnormalities in schizophrenia patients with poor insight(Insight-),relative to patients with preserved clinical insight(Insight+),and healthy controls.METHODS Forty stable schizophrenia outpatients(20 Insight-and 20 Insight+) and 20 healthy controls underwent whole brain magnetic resonance imaging(MRI).Insight in all patients was assessed using the Birchwood Insight Scale(BIS;a self-report measure).The two patient groups were preselected to match on most clinical and demographic parameters but,by design,they had markedly distinct BIS scores.Voxel-based morphometry employed in SPM8 was used to examine group differences in grey matter volumes across the whole brain.RESULTS The three participant groups were comparable in age [F(2,57) = 0.34,P = 0.71] and the patient groups did not differ in age at illness onset [t(38) = 0.87,P = 0.39].Insight-and Insight+ patient groups also did not differ in symptoms on the Positive and Negative Syndromes scale(PANSS):Positive symptoms [t(38) = 0.58,P = 0.57],negative symptoms [t(38) = 0.61,P = 0.55],general psychopathology [t(38) = 1.30,P = 0.20] and total PANSS scores [t(38) = 0.21,P = 0.84].The two patient groups,as expected,varied significantly in the level of BIS-assessed insight [t(38) = 12.11,P < 0.001].MRI results revealed lower fronto-temporal,parahippocampal,occipital and cerebellar grey matter volumes in Insightpatients,relative to Insight+ patients and healthy controls(for all clusters,family-wise error corrected P < 0.05).Insight+ patient and healthy controls did not differ significantly(P > 0.20) from each other.CONCLUSION Our findings demonstrate a clear association between poor clinical insight and smaller fronto-temporal,occipital and cerebellar grey matter volumes in stable long-term schizophrenia patients. | Adegboyega Sapara Dominic H Ffytche Michael A Cooke Steven CR Williams Veena Kumari | 2016 | World Journal of Psychiatry2016，6，3： | 3 |
| 2 | Windows version of the ion trap simulation program ITSIM: A powerful heuristic and predictive tool in ion trap mass spectrometry显示文摘 | BUI H A COOKS R G | 1998 | Journal of Mass Spectrometry1998，33，4： | 1 |
| 3 | Nuclear Level Densities in Intermediate and Heavy Nuclei显示文摘 | COOK J L FERGUSON H MUSGROVE A R D | 1967 | Australian Journal of Physics1967，20，： | 1 |
| 4 | An arbitrary Lagrangian-Eulerian computing method for all flow speeds显示文摘 | Hirt C W Amsden A A Cook H K | 1974 | J Comput Phys1974，14，： | 1 |
| 5 | Design Method for Bridges on Lead-rubber Bearings显示文摘 | Turkington D H Carr A J Cooke N Moss P J | 1989 | Journal of Structural Engineering1989，115，12： | 1 |
| 6 | Increased serum and testicular androgen levels in F1 rats with lifetime exposure to soy isoflavones 显示文摘 | McVey M J Cooke G M Curran I H A | 2004 | Reproductive Toxicology2004，18，5： | 1 |
| 7 | Regulation of bcl-2 family proteins during development and in response to oxidative stress in cardiac myocytes: association with changes in mitoehondrial membrane potential 显示文摘 | Cook S A Sugden P H Clerk A | 1999 | Cire Ras1999，85，10： | 1 |
| 8 | Fluoride and tea 显示文摘 | Cook H A France B A | 1976 | Lancet1976，26，： | 1 |
| 9 | Molecular Order and Structure in Enzyme-resistant Retrograted Starch 显示文摘 | Gidley M J Cooke D Drake A H | 1995 | Carbohydr Polym1995，28，： | 1 |
| 10 | Rates of stone loss at St Paul' s Cathedral, London 显示文摘 | Trudgill S T Viles H A Cooke R U | 1990 | Atmospheric Enviroltment ( Part B)1990，24，2： | 1 |
| 11 | Trendsin stone weathering and atmospheric-pollution at St-Pauls-Cathedral, Lon- don, 1980-1990 显示文摘 | Trudgill S T Viles H A Cooke R U | 1991 | Atmospheric Environment ( Part A )1991，25，： | 1 |
| 12 | Dopamine transporter gene variation modulates activation of striatum in youth with ADHD显示文摘 | Bedard A C Schulz K P Cook E H | 2010 | Neuroimage2010，53，3： | 1 |
| 13 | Mechanisms Influencing the Evolution of Resistance to Qo Inhibitor Fungicides显示文摘 | GISI U SIEROTZKI H COOK A | 2002 | Pest Management Science2002，58，： | 1 |
| 14 | An inhibitor do-main in c-Fos regulates activation domains containing the HOB1 motif显示文摘 | Brown H J Sutherland J A Cook A | | 0，，01： | 1 |
| 15 | Forest decline: Modeling the effect of climate in tree ring 显示文摘 | COOK E R JOHNSON A H BLASING T J | 1987 | Tree Physiology1987，3，1： | 1 |
| 16 | Sensitivity of the WRF model to advection and diffusion schemes for simulation of heavy rainfall along the Baiu front 显示文摘 | Kusaka H Cook A Knievel I C | 2005 | Scientific Online Letters on the Atmosphere2005，1，： | 1 |
| 17 | Marine ecosystems: Bacterial photosynthesis genes in a virus显示文摘 | MANN N H COOK A MILLARD A | 2003 | Nature2003，424，6950： | 1 |
| 18 | The role of bacteria in the digestion of seaweed by the abalone Haliotis midae显示文摘 | ERASMUS J H COOK P A COYNE V E | 1997 | Aquaculture1997，155，： | 1 |
| 19 | Development,field evaluation,and agronomic performance ortransgenic herbicide resistant rice显示文摘 | Oard J H Cook K A Gomez J H | 1996 | Molecular Breeding1996，2，： | 1 |
| 20 | The key role of pulsed- field gel electroph- oresis in investigation of a large multiserotype and muhistate food-borne outbreak of Salmonella infections centered in Pennsylvania 显示文摘 | Sandt C H Krouse D A Cook C R | 2006 | Clin Microbiol2006，44，9： | 1 |
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