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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Tumor necrosis factor-alpha neutralization reduces lung injury after experimental allogeneic bone marrow transplantation显示文摘 | Cooke K R Hill G R Gerbitz A | 2000 | Transplantation2000，70，2： | 2 |
| 3 | Short term evaluation of carbon coated and uncoated porous titanium implants clin显示文摘 | COOK S D HADDAD R J | 1989 | Clin Mater1989，4，： | 1 |
| 4 | The pathogenesis of turkey rhinotracheitis virus in turkey poults inoculate with the virus alone or together with two stains of bacteria显示文摘 | Cook J K A Ellis M M Huggins M B | 1991 | Avian Pathol1991，20，： | 1 |
| 5 | Effects of T-2 mycotoxin on gastrointestinal tissues : a review of in vivo and in vitro models 显示文摘 | WORRELL N R MALLETT A K COOK W M | 1989 | Environ Toxicol1989，18，1： | 1 |
| 6 | The effects of increaseddose of exercise-based therapies to enhance motor recoveryafter stroke: a systematic review and meta-analysis显示文摘 | Cooke EV Mares K Clark A | 2010 | BMCMed2010，8，： | 1 |
| 7 | A recombinant fowlpox virus that expresses the VP2 antigen of infectious bursal disease virus induces protection against mortality caused by the virus显示文摘 | BAYLISS C D PETERS R W COOK J K A | 1991 | Arch Virol1991，120，： | 1 |
| 8 | An arbitrary Lagrangian-Eulerian computing method for all flow speeds显示文摘 | Hirt C W Amsden A A Cook H K | 1974 | J Comput Phys1974，14，： | 1 |
| 9 | Curly bare (cub) ,a new mouse mutation on chromosome 11 cau- sing skin and hair abnormalities, and a modifies gene( mcub) on chromosome 5 显示文摘 | Johnson K R Lane P W Cook S A | 2003 | Genomics2003，81，1： | 1 |
| 10 | Betaine in sub- acute and sub-chronic rat studies显示文摘 | HAYES K C PRONCZUK A COOK M W | 2003 | Food Chem Toxicol2003，41，12： | 1 |
| 11 | Large-scale analysis of the human and mouse rranscriptomes显示文摘 | SU A I COOKE M P CHING K A | 2002 | Proc Natl Acad Sci USA2002，99，7： | 1 |
| 12 | Synthesis of carbon nanotubes containing metal oxides and metals of the d-block and f-block transition metals and related studies显示文摘 | CHEN Y K CHU A COOK J | 1997 | J Mat Chem1997，7，： | 1 |
| 13 | Phylogeography of Black Bears (Ursus americanus) of the Pacific Northwest 显示文摘 | Stone K D Cook J A | 2000 | Canadian Journal of Zoology2000，78，7： | 1 |
| 14 | Effects of chronic inhibition of GABA synthesis on attention and impulse control显示文摘 | PAINE T A COOKE E K LOWES D C | 2015 | Pharmacol Biochem Behav2015，135，： | 1 |
| 15 | Direct Measurement of Timing: Underpinning a Reliable Petroleum System Model for the Mid-Continent Rift System 显示文摘 | Hegarty K A Foland S S Cook A C | 2007 | AAPG Bulletin2007，91，7： | 1 |
| 16 | Host dendriticcells alone are sufficient to initiate acute graft-versus-host disease显示文摘 | DUFFNER U A MAEDA Y COOKE K R | 2004 | J Immunol2004，172，12： | 1 |
| 17 | Rocks matter:Ground truth in geomechanics显示文摘 | COOK J FREDERIKSEN R A HASBO K | 2007 | Oilfield Review2007，19，3： | 1 |
| 18 | CD4 T cells and their antigens in the pathogenesis of autoimmune diabetes显示文摘 | Haskins K Cooke A | 2011 | Cuit Opin Immunol2011，23，6： | 1 |
| 19 | Dopamine transporter gene variation modulates activation of striatum in youth with ADHD显示文摘 | Bedard A C Schulz K P Cook E H | 2010 | Neuroimage2010，53，3： | 1 |
| 20 | Calmidazolium is a potent stimulator of steroidogenesis via mechanisms not involving cyclic AMP,calcium or protein synthesis显示文摘 | CHOI M S K COOKE B A | 1992 | Biochem J1992，281，： | 1 |
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