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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Software process validation:quantitatively measuring the correspondence of a process to a model显示文摘 | WOLF A L | 1999 | ACM Transactions on Software Engineering and Methodology1999，8，2： | 1 |
| 3 | Fibroblast growth factor, epidermal growth factor, and platelet derived growth factor-BB stimulate proliferation of clonally derived porcine myogenic satellite cells显示文摘 | Doumit M E Cook D R Merkel R A | 1993 | J Cell Physiol1993，157，： | 1 |
| 4 | Diurnal variations in hydraulic conductivity and root pressure can be correlated with the expression of putative aquaporlns in the roots of Lotus japonicus显示文摘 | HENZLER T WATERHOUSE R N SMYTH A J CARVAJAL M COOKE D T SCHAFFNER A R STEUDLE E CLARKSOND T | 1999 | Planta1999，210，： | 1 |
| 5 | Urban landscape network: an ecological planning framework显示文摘 | Cook E A | 1991 | Landscape Research1991，16，3： | 1 |
| 6 | Three-dimensional seismic geomorphology of a deep-water slope-channel system:the Sequoia field, offshore west Nile Delta, Egypt显示文摘 | Cross N E Cunningham A Cook R J | 2008 | AAPG Bulletin2008，92，8： | 1 |
| 7 | Isolation of Resistance Gene Candidates (RGCs) and characterization of an RGC cluster in cassava显示文摘 | Lopez C E Zuluaga A P Cooke R | 2003 | Molecular Genetics and Genomics2003，269，5： | 1 |
| 8 | Bonded stress model for design of adhesive anchors 显示文摘 | Cook R A Dpeer G T Klingner R E | 1993 | ACI Structural Journal1993，90，5： | 1 |
| 9 | Three-dimen-sional seismic geomorphology of a deep-water slope-channelsystem:The Sequoia field,offshore west Nile Delta,Egypt显示文摘 | Cross N E Cunningham A Cook R J | 2009 | AAPG Bulletin2009，93，： | 1 |
| 10 | A molecular phylogeny of Phytophthora and related oomycetes显示文摘 | COOKE D E L DRENTH A DUNCAN J M | 2000 | Fungal Genetics and Biology2000，30，： | 1 |
| 11 | The Effect of time Delay and Growth Rate Inhibition in the Bacterial Treatment of Wastewater显示文摘 | Bush A W Cook S E | 1975 | J Thoo- ret Biol1975，63，： | 1 |
| 12 | Ductile Multiple-Anchor Steel-to-Concrete Connections显示文摘 | Ronald A Cook Richard E Klingner | 1992 | Journal of Structural Engineering1992，118，6： | 1 |
| 13 | Self-processing 2A polyproteins-a system for co-ordinate expression of multiple pro teins in transgenic plants显示文摘 | Halpin C Cooke S E Barakate A | 1999 | J The Plant Joural1999，17，4： | 1 |
| 14 | Evidence of compositional differences between the extracellular and intracellular DNA of a granular sludge biofilm 显示文摘 | Cheng M Cook A E Fukushima T | 2011 | Appl Microbiol Lett2011，53，： | 1 |
| 15 | Transition stages of ray- leigh-Taylor instability between miscible fluids显示文摘 | Cook A W Dimotakis P E | 2001 | Journal of Fluid Mechanics2001，443，： | 1 |
| 16 | Small cell lung cancer: etiology, biology, clinical features, staging, and treatment 显示文摘 | Cook R M Miller Y E Bunn P A Jr | 1993 | Curr Probl Cancer1993，17，2： | 1 |
| 17 | Bond stress model for design of adhesive anchors显示文摘 | Cook R A Doerr G T Klingner R E | 1993 | ACI Structural Journal1993，90，5： | 1 |
| 18 | Enhanced in- cidence of legabnormalies in reovirus WVU2937 - infected chickens fedvarious dietary levels of select- ed vitamins显示文摘 | Cook M E Sppinger W T Hebert J A | 1983 | Avian Diseases1983，28，3： | 1 |
| 19 | Effects of chronic inhibition of GABA synthesis on attention and impulse control显示文摘 | PAINE T A COOKE E K LOWES D C | 2015 | Pharmacol Biochem Behav2015，135，： | 1 |
| 20 | Landscape structure indices for assessing ur- ban ecological networks 显示文摘 | COOK E A | 2002 | Landscape and Urban Plan- ning2002，58，2： | 1 |
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