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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Assessment of management alternatives on a small agricultural watershed 显示文摘 | Mostaghimi S Park S W Cooke R A | 1997 | Water Research1997，31，8： | 1 |
| 3 | An arbitrary Lagrangian-Eulerian computing method for all flow speeds 显示文摘 | Hirt G W Amsden A A Cook J L | 1974 | J Comp Phys1974，14，3： | 1 |
| 4 | An arbitrary Lagrangian- Eulerian computing method for all flow speeds 显示文摘 | Hirt C W Amsden A A Cook J L | 1997 | Journal of Computational Physics1997，135，2： | 1 |
| 5 | Effects of T-2 mycotoxin on gastrointestinal tissues : a review of in vivo and in vitro models 显示文摘 | WORRELL N R MALLETT A K COOK W M | 1989 | Environ Toxicol1989，18，1： | 1 |
| 6 | A recombinant fowlpox virus that expresses the VP2 antigen of infectious bursal disease virus induces protection against mortality caused by the virus显示文摘 | BAYLISS C D PETERS R W COOK J K A | 1991 | Arch Virol1991，120，： | 1 |
| 7 | Simultaneous axial and rotational electron beam velocity measurement using a phosphor scintillator显示文摘 | He W Cooke S J Cross A W | 2001 | Review of Scientific Instruments2001，72，5： | 1 |
| 8 | The Effect of time Delay and Growth Rate Inhibition in the Bacterial Treatment of Wastewater显示文摘 | Bush A W Cook S E | 1975 | J Thoo- ret Biol1975，63，： | 1 |
| 9 | An arbitrary Lagrangian-Eulerian computing method for all flow speeds显示文摘 | Hirt C W Amsden A A Cook H K | 1974 | J Comput Phys1974，14，： | 1 |
| 10 | Analysis of the human type I insulin - like growth factor receptor promoter region 显示文摘 | Cooke D W Bankert L A Roberts C T Jr | 1991 | Biochemical and Biophysical Research Communications1991，177，3： | 1 |
| 11 | Curly bare (cub) ,a new mouse mutation on chromosome 11 cau- sing skin and hair abnormalities, and a modifies gene( mcub) on chromosome 5 显示文摘 | Johnson K R Lane P W Cook S A | 2003 | Genomics2003，81，1： | 1 |
| 12 | Betaine in sub- acute and sub-chronic rat studies显示文摘 | HAYES K C PRONCZUK A COOK M W | 2003 | Food Chem Toxicol2003，41，12： | 1 |
| 13 | The inner centro- mere protein (INCENP) antigens: movement from inner een- tromere to midbody during mitosis显示文摘 | Cooke C A Heck M M Earnshaw W C | 1987 | J Cell Biol1987，105，5： | 1 |
| 14 | A subgrid model for equilibrium chemistry in turbulent flows显示文摘 | Cook A W Riley J J | 1994 | Physics of Fluids1994，6，： | 1 |
| 15 | The relational grid monitoring architecture:mediating information about the grid 显示文摘 | Cooke A W Gray A J G | 2004 | Journal of Grid Computing2004，2，4： | 1 |
| 16 | The preparation of SiGe thermoelectric materials by mechanical mlloying显示文摘 | Cook B A Beaudry B J Harringa W J | 1989 | Institute of Electrical and Electronics Engineers1989，89，3： | 1 |
| 17 | Behavior and design of single adhesive anchors under tensile load in uncracked con- crete显示文摘 | Cook R A Kunz J Fuchs W | 1998 | ACI Structural Journal1998，95，1： | 1 |
| 18 | Transition stages of ray- leigh-Taylor instability between miscible fluids显示文摘 | Cook A W Dimotakis P E | 2001 | Journal of Fluid Mechanics2001，443，： | 1 |
| 19 | Hydrocarbon potential of the Barnett Shale (Mississippian) Delaware Basin, West Texas and Southeastem New Mexico 显示文摘 | Kinley T J Cook L W Breyer J A | 2008 | AAPG Bulletin2008，92，8： | 1 |
| 20 | Effect of partial middle turbinectomy on nasal airflow and resistance 显示文摘 | COOK P R BEGEGNI A BRYANT W C | 1995 | Otolaryngol Head Neck Surg1995，113，： | 1 |
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