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| 1 | Factors associated with long-term survival after liver transplantation:A retrospective cohort study显示文摘AIM To identify predictive factors associated with long-term patient and graft survival(> 15 years) in liver transplant recipients.METHODS Medical charts of all de novo adult liver transplant recipients(n = 140) who were transplanted in Hamburg between 1997 and 1999 were retrospectively reviewed.In total,155 transplantations were identified in this time period(15 re-transplantations).Twenty-six orthotopic liver transplant(OLT) recipients were early lost to followup due to moving to other places within 1 year after transplantation.All remaining 114 patients were included in the analysis.The following recipient factors were analysed:Age,sex,underlying liver disease,pre-OLT body mass index(BMI),and levels of alanine aminotransferase(ALT),bilirubin,creatinine and gammaglutamyltransferase(gamma-GT),as well as warm and cold ischemia times.Furthermore,the following donor factors were assessed:Age,BMI,cold ischemia time and warm ischemia time.All surviving patients were followed until December 2014.We divided patients into groups according to their underlying diagnosis:(1) hepatocellularcarcinoma(n = 5,4%);(2) alcohol toxic liver disease(n = 25,22.0%);(3) primary sclerosing cholangitis(n = 6,5%);(4) autoimmune liver diseases(n = 7,6%);(5) hepatitis C virus cirrhosis(n = 15,13%);(6) hepatitis B virus cirrhosis(n = 21,19%);and(7) other(n = 35,31%).The group 'other' included rare diagnoses,such as acute liver failure,unknown liver failure,stenosis and thrombosis of the arteria hepatica,polycystic liver disease,Morbus Osler and Caroli disease.RESULTS The majority of patients were male(n = 70,61%).Age and BMI at the time point of transplantation ranged from 16 years to 69 years(median:53 years) and from 15 kg/m^2 to 33 kg/m^2(median:24),respectively.Sixty-six OLT recipients(58%) experienced a follow-up of 15 years after transplantation.Recipient's age(P = 0.009) and BMI(P = 0.029) were identified as risk factors for death by χ~2-test.Kaplan-Meier analysis confirmed BMI or age above the median as predictors of decreased long-term survival(P = 0.008 and P = 0.020).Hepatitis B as underlying disease showed a trend for improved long-term survival(P = 0.049,χ~2-test,P = 0.055;Kaplan-Meier analysis,Log rank).Pre-transplant bilirubin,creatinine,ALT and gamma-GT levels were not associated with survival in these patients of the pre-era of the model of end stage liver disease.CONCLUSION The recipients' age and BMI were predictors of longterm survival after OLT,as well as hepatitis B as underlying disease.In contrast,donors' age and BMI were not associated with decreased survival.These findings indicate that recipient factors especially have a high impact on long-term outcome after liver transplantation. | Sven Pischke Marie C Lege Moritz von Wulffen Antonio Galante Benjamin Otto Malte H Wehmeyer Uta Herden Lutz Fischer Bjorn Nashan Ansgar W Lohse Martina Sterneck | 2017 | World Journal of Hepatology2017，9，8： | 5 |
| 2 | Ruptured angiosarcoma of the liver treated by emergency catheter-directed embolization显示文摘血管肉瘤是有差的预后的肝的一个稀罕的主要的恶意的瘤。这里,我们与被紧急情况对待的一个破裂的肝的血管肉瘤报导一个病人的一个案例指导导管的 embolization,由左边的偏身出汗列在后面。 | Christine Leowardi Yura Hormann UIf Hinz Moritz N Wente Peter Hallscheidt Christa Flechtenmacher Markus W Büchler Helmut Friess Matthias HM Schwarzbach | 2006 | World Journal of Gastroenterology2006，12，5： | 4 |
| 3 | Glucose control and vascular complications in veterans with type 2 diabetes显示文摘 | Duckworth W Abraira C Moritz T | | New England Journal of Medicine0，，： | 3 |
| 4 | Evolution of animal mitochondrial:relevance for population biology and systematics 显示文摘 | MORITZ C DOWLING T E BROWN W M | 1987 | Annu Rev Ecol Syst1987，187，： | 2 |
| 5 | Apoptosis in hypoxic human pa- ncreatic islets correlates with HIF-lalpha expression 显示文摘 | Moritz W Meier F Stroka DM | 2002 | Faseb J2002，16，7： | 1 |
| 6 | Glucose control and vascular complications in veterans with type 2 diabetes显示文摘 | Duckworth W Abraira C Moritz T | | 0，，： | 1 |
| 7 | Serotonin promotes tumor growth in human hepatocellular cancer显示文摘 | SOLL C JANG J H RIENER M O MORITZ W WILD P J GRAF R | 2010 | Hepatology2010，51，： | 1 |
| 8 | Glucose control and vascular complications in veterans with type 2 diabetes显示文摘 | Duckworth W Abraira C Moritz T | 2009 | N Engl J Med2009，360，2： | 1 |
| 9 | Glucose control and vascular complications in veterans with type 2 diabetes显示文摘 | Duckworth W Abraira C Moritz T | | 0，，02： | 1 |
| 10 | Glucose control and vascular complications in veterans with type 2 diabetes显示文摘 | Duckworth W Abraira C Moritz T | | 0，，02： | 1 |
| 11 | Glucose control and vascular complications in veterans with type 2 diabetes显示文摘 | Duckworth W Abraira C Moritz T | 2009 | N Engl J Med2009，360，2： | 1 |
| 12 | Evolution of animal mitochondrial DNA:Relevance for population biology and systematics显示文摘 | MORITZ C DOWLING T E BRORN W M | | Annu Rev Ecol Syst0，18，： | 1 |
| 13 | Effect of surfactant and particle size reduction on hydrolysis of deinking sludge and nonrecyclable newsprint显示文摘 | Duff Sheldon J B Moritz John W Casavant Tracy E | 1995 | Biotechnology and Bioengineering1995，45，3： | 1 |
| 14 | Glucose control and vascu- lar complications in veterans with type 2 diabetes显示文摘 | Duckworth W Abraira C Moritz T | 2009 | The New Eng- land Journal of Medicine2009，360，： | 1 |
| 15 | Glucose control and vascular complications in veterans with type 2 diabetes显示文摘 | Duckworth W Abraira C Moritz T | 2009 | N Engl J Med2009，360，2： | 1 |
| 16 | Biotechnological and gene therapeutic strategies in cancer treatment显示文摘 | Wels W Moritz D Schm idt M | 1995 | Gene1995，159，1： | 1 |
| 17 | Bactericidal effect of dif- ferent laser systems in the deep layers of dentin显示文摘 | Schoop U Kluger W Moritz A | 2004 | Lasers Surg Med2004，35，2： | 1 |
| 18 | Glucose control and vas- cular complications in veterans with type 2 diabetes 显示文摘 | Duckworth W Abraira C Moritz T | 2009 | N Engl J Med2009，360，2： | 1 |
| 19 | Glucose control and vascular complications in veterans with type 2 diabetes显示文摘 | Duckworth W Abraira C Moritz T | 2009 | N Engl J Med2009，360，2： | 1 |
| 20 | Has time come for new goals in human islet transplantation? 显示文摘 | Lehmann R Spinas GA Moritz W | 2008 | Am J Transplant2008，8，6： | 1 |
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