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| 1 | Predictive biomarkers for immune checkpoint blockade and opportunities for combination therapies显示文摘Immune checkpoint blockade therapies(ICBs)are a prominent breakthrough in cancer immunotherapy in recent years(named the 2013“Breakthrough of the Year”by the Science magazine).Thus far,FDA-approved ICBs primarily target immune checkpoints CTLA-4,PD-1,and PD-L1.Notwithstanding their impressive long-term therapeutic benefits,their efficacy is limited to a small subset of cancer patients.In addition,ICBs induce inadvertent immune-related adverse events(irAEs)and can be costly for long-term use.To overcome these limitations,two strategies are actively being pursued:identification of predictive biomarkers for clinical response to ICBs and multi-pronged combination therapies.Biomarkers will allow clinicians to practice a precision medicine approach in ICBs(biomarker-based patient selection)such as treating triple-negative breast cancer patients that exhibit PD-L1 staining of tumor-infiltrating immune cells in1%of the tumor area with nanoparticle albumin-bound(nab)epaclitaxel plus anti-PD-L1 and treating patients of MSI-H or MMR deficient unresectable or metastatic solid tumors with pembrolizumab(anti-PD-1).Importantly,the insights gained from these biomarker studies can guide rational combinatorial strategies such as CDK4/6 inhibitor/fractionated radiotherapy/HDACi in conjunction with ICBs to maximize therapeutic benefits.Further,with the rapid technological advents(e.g.,ATCT-Seq),we predict more reliable biomarkers will be identified,which in turn will inspire more promising combination therapies. | Hongxing Shen Eddy Shih-Hsin Yang Marty Conry John Fiveash Carlo Contreras James A.Bonner Lewis Zhichang Shi | 2019 | Genes & Diseases2019，6，3： | 5 |
| 2 | Human autoantibodies to carcinoembryonic antigen (CEA) induced by a vaccinia-CEA vaccine 显示文摘 | Conry RM Allen KO Lee H | 2000 | ClinCancer Res2000，6，1： | 2 |
| 3 | Inverted question mark ho--mocys- teinemia : role in vascular disease 显示文摘 | Conri C Constans J Parrot F | 2000 | Presse Med2000，29，： | 1 |
| 4 | Circulating markers of endothelial function in cardiovascular disease显示文摘 | Constans J Conri C | 2006 | Clin Chim Acta2006，368，12： | 1 |
| 5 | Stable dosages of clobazam for Lennox-Gastaut syndrome are associated with sustained drop- seizure and total-Seizure improvements over 3 years 显示文摘 | Conry JA Ng YT Kernitsky L | 2014 | Epilepsia2014，55，4： | 1 |
| 6 | Flip My Class ! A faculty development demonstra- tion of a flipped-classroom 显示文摘 | See S Conry JM | 2014 | Currents Pharmacy Teach Learn2014，6，： | 1 |
| 7 | Levels of plasma thrombomodulin are increased in atheromatous arterial disease显示文摘 | Seigneur M Dufourcq P Conri C | 1993 | Thromb Res1993，71，6： | 1 |
| 8 | A mathematical programming method for design of elastic bodies in contact显示文摘 | Conry T F Seireg A | 1971 | ASME J Appl Mech1971，38，2： | 1 |
| 9 | Human immune response to monoclonal antibodies显示文摘 | Khazaeli MB Conry RM LoBuglio AF | 1994 | J Immunother1994，15，1： | 1 |
| 10 | The effect of surface irregularities on the elastohydrodynamic lubrication of sliding line contacts, Part Ⅱ-wavy surface显示文摘 | GOGLIA P CUSANO C CONRY T F | 1984 | ASME Journal of Tribology1984，106，： | 1 |
| 11 | Clobazam in the treatment of Lennox-Gastaut syndrome显示文摘 | Conry JA Ng YT Paolicchi JM | | 0，，05： | 1 |
| 12 | Human immune respouse to monoclonal antibodies 显示文摘 | Khazaeli MB Conry RM LoBuglio AF | 1994 | Immunother1994，15，1： | 1 |
| 13 | Human autoantibodies to carcinoembryonic antigen (CEA) induced by a vaccinia-CEA vaccine 显示文摘 | Conry RM Allen KO Lee S | 2000 | Clin Cancer Res2000，6，1： | 1 |
| 14 | Effect of timing of N application on the grain yield and grain quality of spring-sown malting barley 显示文摘 | Conry M J | 1995 | Irish Journal of Agriculture and Food Research1995，，： | 1 |
| 15 | Vitamin C pharmacokinetics in healthy volunteer:evidence for a recommended dietary allowance显示文摘 | Levine M Conry CC Wang Y | 2006 | Proc Natl Acad Sci USA2006，93，： | 1 |
| 16 | Fetal alcohol spectrum disorder: Canadian guidelines for diagnosis显示文摘 | Chudley A E Conry J Cook J L | 2005 | CMAJ2005，172，5： | 1 |
| 17 | Human autoantibodies to carcinoembryonic antigen (CEA) induced by a vaccinia-CEA vaccine显示文摘 | Conry R M Allen K O Lee S | 2000 | Clin Cancer Res2000，6，1： | 1 |
| 18 | Effects of Lubricant Rheology and Kinematic Conditions on Micro-Elastohydrodynamic Lubrication显示文摘 | CHANG L CUSANO C CONRY T F | 1989 | ASME Journal of Tribology1989，111，： | 1 |
| 19 | Safety and immunogenicity of a DNA vaccine encoding carcinoembryonic antigen and hepatitis B surface antigen in colorectal carcinoma patients显示文摘 | Conry RM Curiel DT Strong TV | 2002 | Clin Cancer Res2002，8，9： | 1 |
| 20 | Variations in serum vanadium levels during the mental depression 显示文摘 | Conri C Simonoff M Fleury B | 1986 | Biol Psychiat1986，，： | 1 |
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