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| 1 | Laparoscopic fundoplication for gastroesophageal reflux disease显示文摘Gastroesophageal reflux disease(GERD) is a condition that develops when the reflux of gastric contents into the esophagus leads to troublesome symptoms and/or complications. Heartburn is the cardinal symptom, often associated with regurgitation. In patients with endoscopy-negative heartburn refractory to proton pump inhibitor(PPI) therapy and when the diagnosis of GERD is in question, direct reflux testing by impedance-pH monitoring is warranted. Laparoscopic fundoplication is the standard surgical treatment for GERD. It is highly effective in curing GERD with a 80% success rate at 20-year follow-up. The Nissen fundoplication, consisting of a total(360°) wrap, is the most commonly performed antireflux operation. To reduce postoperative dysphagia and gas bloating, partial fundoplications are also used, including the posterior(Toupet) fundoplication, and the anterior(Dor) fundoplication. Currently, there is consensus to advise laparoscopic fundoplication in PPI-responsive GERD only for those patients who develop untoward side-effects or complications from PPI therapy. PPI resistance is the real challenge in GERD. There is consensus that carefully selected GERD patients refractory to PPI therapy are eligible for laparoscopic fundoplication, provided that objective evidence of reflux as the cause of ongoing symptoms has been obtained. For this purpose, impedance-pH monitoring is regarded as the diagnostic gold standard. | Marzio Frazzoni Micaela Piccoli Rita Conigliaro Leonardo Frazzoni Gianluigi Melotti | 2014 | World Journal of Gastroenterology2014，20，39： | 10 |
| 2 | Cholangiocarcinoma and malignant bile duct obstruction: A review of last decades advances in therapeutic endoscopy显示文摘In the last decades many advances have been achieved in endoscopy, in the diagnosis and therapy of cholangiocarcinoma, however blood test, magnetic resonance imaging, computed tomography scan may fail to detect neoplastic disease at early stage, thus the diagnosis of cholangiocarcinoma is achieved usually at unresectable stage. In the last decades the role of endoscopy has moved from a diagnostic role to an invaluable therapeutic tool for patients affected by malignant bile duct obstruction. One of the major issues for cholangiocarcinoma is bile ducts occlusion, leading to jaundice, cholangitis and hepatic failure. Currently, endoscopy has a key role in the work up of cholangiocarcinoma, both in patients amenable to surgical intervention as well as in those unfit for surgery or not amenable to immediate surgical curative resection owing to locally advanced or advanced disease, with palliative intention. Endoscopy allows successful biliary drainage and stenting in more than 90% of patients with malignant bile duct obstruction, and allows rapid reduction of jaundice decreasing the risk of biliary sepsis. When biliary drainage and stenting cannot be achieved with endoscopy alone, endoscopic ultrasound-guided biliary drainage represents an effective alternative method affording successful biliary drainage in more than 80% of cases. The purpose of this review is to focus on the currently available endoscopic management options in patients with cholangiocarcinoma. | Helga Bertani Marzio Frazzoni Santi Mangiafico Angelo Caruso Mauro Manno Vincenzo Giorgio Mirante Flavia Pigò Carmelo Barbera Raffaele Manta Rita Conigliaro | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，6： | 8 |
| 3 | 单个汽球 enteroscopy : 技术方面和临床的应用显示文摘 The small bowel has long been considered a black box for endoscopists because of its long length and the presence of multiple complex loop. Most of the small bowel is inaccessible by traditional endoscopic means. In addition, radiographic studies have significant limitations with regard to diagnostic yield, and surgery is an invasive alternative. This limitation was overcome through the development of balloon enteroscopy that becomes established throughout the world for diagnostic and therapeutic examinations of the small bowel. The single-balloon enteroscope (SBE) system (Olympus, Tokyo, Japan) was introduced into the commercial market in 2007. Several study demonstrated its efficacy and safety. Early reports on the use of singleballoon enteroscopy have suggested a high diagnostic yield and similar therapeutic potential to that of the double-balloon endoscope. SBE is viable technique for in the management of small bowel disease. Technically, it is easy to perform, may be efficient, and in the literature data available, seems to provide high diagnostic and therapeutic yield. | Mauro Manno Carmelo Barbera Helga Bertani Raffaele Manta Vincenzo Giorgio Mirante Emanuele Dabizzi Angelo Caruso Flavia Pigo Giampiero Olivetti Rita Conigliaro | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，2： | 8 |
| 4 | Linear endoscopic ultrasonography vs magnetic resonance imaging in ampullary tumors显示文摘AIM:To assess linear endoscopic ultrasound (L-EUS) and magnetic resonance imaging (MRI) in biliary tract dilation and suspect small ampullary tumor.METHODS:L-EUS and MRI data were compared in 24 patients with small ampullary tumors;all with subsequent histological confirmation.Data were collected prospectively and the accuracy of detection,histological characterization and N staging were assessed retrospectivelyusing the results of surgical or endoscopic treatment as a benchmark.RESULTS:A suspicion of ampullary tumor was present in 75% of MRI and all L-EUS examinations,with 80% agreement between EUS and histological findings at endoscopy.However,L-EUS and histological TN staging at surgery showed moderate agreement (κ=0.54).CONCLUSION:L-EUS could be a useful adjunct as a diagnostic tool in the evaluation of patients with sus-pected ampullary tumors. | Raffaele Manta Rita Conigliaro Danilo Castellani Alessandro Messerotti Helga Bertani Giuseppe Sabatino Elena Vetruccio Luisa Losi Vincenzo Villanacci Gabrio Bassotti | 2010 | World Journal of Gastroenterology2010，16，44： | 6 |
| 5 | Endoscopic ultrasonography findings in autoimmune pancreatitis显示文摘Endoscopic ultrasonography is an established diagnostic tool for pancreatic masses and chronic pancreatitis.In recent years there has been a growing interest in the worldwide medical community in autoimmune pancreatitis (AIP),a form of chronic pancreatitis caused by an autoimmune process.This paper reviews the current available literature about the endoscopic ultrasonographic findings of AIP and the role of this imaging technique in the management of this protean disease. | Elisabetta Buscarini Stefania De Lisi Paolo Giorgio Arcidiacono Maria Chiara Petrone Arnaldo Fuini Rita Conigliaro Guido Manfredi Raffaele Manta Dario Reggio Claudio De Angelis | 2011 | World Journal of Gastroenterology2011，17，16： | 6 |
| 6 | Needle-based confocal endomicroscopy in the discrimination of mucinous from non-mucinous pancreatic cystic lesions显示文摘BACKGROUND Pancreatic cystic lesions(PCLs)are considered a precursor of pancreatic cancer.Needle-based confocal endomicroscopy(nCLE)is an imaging technique that enables visualization of the mucosal layer to a micron resolution.Its application has demonstrated promising results in the distinction of PCLs.This study evaluated the utility of nCLE in patients with indeterminate PCLs undergoing endoscopic ultrasound fine-needle aspiration(EUS-FNA)to distinguish mucinous from non-mucinous lesions.AIM To evaluate the accuracy of nCLE in indeterminate PCLs undergoing EUS-FNA to distinguish mucinous from non-mucinous lesions.METHODS Patients who required EUS-FNA between 2015 and 2017 were enrolled prospectively.During EUS-FNA,confocal imaging,analyses of the tumor markers carcinoembryonic antigen and amylase,and cytologic examination were conducted.All patients were followed for at least 12 mo and underwent laboratory testing and computed tomography scanning or magnetic resonance imaging.nCLE videos were independently reviewed by 6 observers to reach a final diagnosis(mucinous vs non-mucinous)based on criteria derived from previous studies;if there was disagreement>20%,a final diagnosis was discussed after consensus re-evaluation.The sensitivity,specificity,and accuracy of nCLE were calculated.Adverse events were recorded.RESULTS Fifty-nine patients were included in this study.Final diagnoses were derived from surgery in 10 patients,cytology in 13,and imaging and multidisciplinary team review in 36.Three patients were excluded from final diagnosis due to problems with nCLE acquisition.Fifty-six patients were included in the final analysis.The sensitivity,specificity,and accuracy of nCLE were 80%[95%confidence interval(CI):65-90],100%(95%CI:72-100),and 84%(95%CI:72-93),respectively.Postprocedure acute pancreatitis occurred in 5%.CONCLUSION EUS-nCLE performs better than standard EUS-FNA for the diagnosis of indeterminate PCL. | Helga Bertani Raffaele Pezzilli Flavia Pigo Mauro Bruno Claudio De Angelis Guido Manfredi Gabriele Delconte Rita Conigliaro Elisabetta Buscarini | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，11： | 4 |
| 7 | Over-the-scope clips in the treatment of gastrointestinal tract iatrogenic perforation: A multicenter retrospective study and a classification of gastrointestinal tract perforations显示文摘AIM: To determine the outcome of the management of iatrogenic gastrointestinal tract perforations treated by over-the-scope clip(OTSC) placement.METHODS: We retrospectively enrolled 20 patients(13 female and 7 male; mean age: 70.6 ± 9.8 years) in eight high-volume tertiary referral centers with upper or lower iatrogenic gastrointestinal tract perforation treated by OTSC placement. Gastrointestinal tract perforation could be with oval-shape or with round-shape. Ovalshape perforations were closed by OTSC only by suction and the round-shape by the 'twin-grasper' plus suction. RESULTS: Main perforation diameter was 10.1 ± 4.3 mm(range 3-18 mm). The technical success rate was 100%(20/20 patients) and the clinical success rate was 90%(18/20 patients). Two patients(10%) who did not have complete sealing of the defect underwent surgery. Based upon our observations we propose two types of perforation: Round-shape 'type-1 perforation' and oval-shape 'type-2 perforation'. Eight(40%) out of the 20 patients had a type-1 perforation and 12 patients a type-2(60%). CONCLUSION: OTSC placement should be attempted after perforation occurring during diagnostic or therapeutic endoscopy. A failed closure attempt does not impair subsequent surgical treatment. | Benedetto Mangiavillano Angelo Caruso Raffaele Manta Roberto Di Mitri Alberto Arezzo Nico Pagano Giuseppe Galloro Filippo Mocciaro Massimiliano Mutignani Carmelo Luigiano Enrico Antonucci Rita Conigliaro Enzo Masci | 2016 | World Journal of Gastrointestinal Surgery2016，8，4： | 3 |
| 8 | Esophageal chemical clearance is impaired in gastro‐esophageal reflux disease – a 24‐h impedance‐pH monitoring assessment显示文摘 | M. Frazzoni R. Manta V. G. Mirante R. Conigliaro L. Frazzoni G. Melotti | 2013 | Neurogastroenterol Motil2013，，5： | 2 |
| 9 | Polyflex stents for malignant oesophageal and oesophagogastric stricture: a prospective, multicentric study显示文摘 | Rita Conigliaro Giorgio Battaglia Alessandro Repici Giovanni De Pretis Luigi Ghezzo Max Bittinger Helmut Messmann Jean-Fran?ois Demarquay Michele Togni Sabrina Blanchi Rosangela Filiberti Massimo Conio | 2007 | European Journal of Gastroenterology & Hepatology2007，，3： | 2 |
| 10 | Endoscopic treatment of gastrointestinal fistulas using an over-the-scope clip (OTSC) device: Case series from a tertiary referral center显示文摘 | R. Manta M. Manno H. Bertani C. Barbera F. Pigò V. Mirante E. Longinotti G. Bassotti R. Conigliaro | 2011 | Endoscopy2011，，06： | 2 |
| 11 | Expression analysis of jagged genes in zebrafish embryos 显示文摘 | zEcCHIN E CONIGLIARO A TISO N | 2005 | Dev Dyn2005，233，： | 1 |
| 12 | Radiofrequency ablation for chronic radiation proctitis: our initial experience with four cases显示文摘 | F. Pigò H. Bertani M. Manno V. G. Mirante A. Caruso R. L. Conigliaro | 2014 | Techniques in Coloproctology2014，，： | 1 |
| 13 | Identifying the cells breaching self-tolerance in autoimmunity 显示文摘 | BENSON RA PATAKAS A CONIGLIARO P | 2010 | J Immunol2010，184，11： | 1 |
| 14 | Pancreatic duct stenting for the duration of ERCP only does not prevent pancreatitis after accidental pancreatic duct cannulation: a prospective randomized trial显示文摘 | Rita Conigliaro Raffaele Manta Helga Bertani Mauro Manno Carmelo Barbera Angelo Caruso Giampiero Olivetti Gianluigi Melotti Marzio Frazzoni | 2013 | Surgical Endoscopy2013，，2： | 1 |
| 15 | The inter-play between inflammation and metabolism in rheumatoidarthritis显示文摘 | Chimenti MS Triggianese P Conigliaro P | 2015 | Cell Death Dis2015，6，： | 1 |
| 16 | The natural history of up- per gastrointestinal subepithelial tumors: a muhicenter endoscopic ul- trasound survey显示文摘 | Gill K R Camellini L Conigliaro R | 2009 | J Clin Gastroenteml2009，43，8： | 1 |
| 17 | Improved Detection of Incident Dysplasia by Probe-Based Confocal Laser Endomicroscopy in a Barrett’s Esophagus Surveillance Program显示文摘 | Helga Bertani Marzio Frazzoni Emanuele Dabizzi Flavia Pigò Luisa Losi Mauro Manno Raffaele Manta Gabrio Bassotti Rita Conigliaro | 2013 | Digestive Diseases and Sciences2013，，1： | 1 |
| 18 | Implementation of sedation guidelines in clinical practice in Italy: results of a prospective longitudinal multicenter study显示文摘 | R. Conigliaro A. Rossi | 2006 | Endoscopy2006，，11： | 1 |
| 19 | i -Scan high-definition white light endoscopy and colorectal polyps: prediction of histology, interobserver and intraobserver agreement显示文摘 | Flavia Pigò Helga Bertani Mauro Manno Vincenzo Mirante Angelo Caruso Carmelo Barbera Raffaele Manta Gabrio Bassotti Gianpiero Olivetti Rita Luisa Conigliaro | 2013 | International Journal of Colorectal Disease2013，，3： | 1 |
| 20 | The interplay between inflammation and metabolism in rheumatoid arthritis 显示文摘 | Chimenti MS Triggianese P Conigliaro P | 2015 | Cell Death Dis2015，6，： | 1 |
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