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| 1 | Relationship of MTHFR gene polymorphisms with renal and cardiac disease显示文摘AIM: To investigate the effects of different methylenetetrahydrofolate reductase(MTHFR) 677C>T gene polymorphism and hyperhomocysteinemia for the development of renal failure and cardiovascular events, which are controversial.METHODS: We challenged the relationship, if any, of MTHFR 677C>T and MTHFR 1298A>C polymorphisms with renal and heart function. The present article is a reappraisal of these concepts, investigating within a larger population, and including a subgroup of dialysis patients, if the two most common MTHFR polymorphisms, C677 T and A1298 C, as homozygous, heterozygous or with a compound heterozygous state, show different association with chronic renal failure requiring hemodialysis. MTHFR polymorphism could be a favorable evolutionary factor, i.e., a protective factor for many ominous conditions, like cancer and renal failure. A similar finding was reported in fatty liver disease in which it is suggested that MTHFR polymorphisms could have maintained and maintain their persistence by an heterozygosis advantage mechanism. We studied a total of 630 Italian Caucasian subject aged 54.60 ± 16.35 years, addressing to the increased hazard of hemodialysis, if any, according to the studied MTHFR genetic polymorphisms. RESULTS: A favorable association with normal renal function of MTHFR polymorphisms, and notably of MTHFR C677 T is present independently of the negative effects of left ventricular hypertrophy, increased IntraRenal arterial Resistance and hyperparathyroidism. CONCLUSION: MTHFR gene polymorphisms could have a protective role on renal function as suggested by their lower frequency among our dialysis patients in end-stage renal failure; differently, the association with left ventricular hypertrophy and reduced left ventricular relaxation suggest some type of indirect, or concurrent mechanism. | Francesca M Trovato Daniela Catalano Angela Ragusa G Fabio Martines Clara Pirri Maria Antonietta Buccheri Concetta Di Nora Guglielmo M Trovato | 2015 | World Journal of Nephrology2015，4，1： | 10 |
| 2 | A halophilic thermotoleran Bacillus isolated from a marine hot spring able to produce a new exopolysaccharide显示文摘 | TERESA L MAUGERI CONCETTA G | 2002 | Biotechnology Letters2002，24，： | 1 |
| 3 | Ferritin heavy chain upregulation by NF-B inhibits TNFα-induced apoptosis bysuppressing reactive oxygen species显示文摘 | Can G Pham Concetta Bubici Francesca Zazzeroni | 2004 | Cell2004，119，11： | 1 |
| 4 | Proteasome inhibitors synergize with tumor necrosis factor-relate apoptosis-indured ligand to induce anaplastic thyroid carcinoma cell death显示文摘 | Concetta C Luana A Raffaella G | 2007 | J Clin Endocrinol Metab2007，92，5： | 1 |
| 5 | A halophilic thermotolerant Bacillus isolated from a marine hot spring able to produce a new exopolysaccharide显示文摘 | TERESA L MAUGERI CONCETTA G | 2002 | Biotechnology Letters2002，24，： | 1 |
| 6 | Immunoglobulin light chain isotypes in the teleost Trematomus bernacchii显示文摘 | Coscia M R Stefano G Concetta D S | | 0，，11： | 1 |
| 7 | In vivo association between low shear stress and plaque in subjects with asymmetrical carotid atherosclerosis显示文摘 | Agostino G Concetta I Claudio C | 1997 | Stroke1997，28，： | 1 |
| 8 | In vivo association between low shear stress and plaque in subject with asymmetrical carotid atherosclerosis显示文摘 | Agostino G Concetta I Claudio C | 1997 | Stroke1997，28，： | 1 |
| 9 | Distribution and diversity of bacteria in a saline meromictic lake as determined by PCR-DGGE of 16S rRNA gene fragments显示文摘 | Concetta G Valeria L Teresa L M | 2011 | Current Microbiology2011，62，15： | 1 |
| 10 | Static stress changes and fault interaction during the 1997 Umbria-Marche earthquake sequence 显示文摘 | Massimo C Concetta N Ekstr6m G | 2000 | J Seismology2000，4，4： | 1 |
| 11 | In vivo association between low shear stress and plaque in subjects with asymmetrical carotid atherosclerosis显示文摘 | Agostino G Concetta I Claudio C | 1997 | Stroke1997，28，： | 1 |
| 12 | Immuno-globulin light chain isotypes in the teleost Trematomusbernacchii显示文摘 | Coscia M R Stefa no G Concetta D S | 2008 | Molecular Immunology2008，45，11： | 1 |
| 13 | Association between intima-media thickness and wall shear stress in common carotid arteries in healthy male subjects 显示文摘 | Agostino G Claudio C Concetta I | 1996 | Circulation1996，94，： | 1 |
| 14 | Changes in the antioxidant systems as part of the signaling pathway responsible for the programmed cell death activated by nitric oxide and reactive oxygen species in Tobacco Bright-Yellow 2 cells显示文摘 | Concetta De P Franca T Laura De G | 2002 | Plant Physiol2002，130，： | 1 |
| 15 | Soft tissue injury protocol (STIP) using motion MRI for cervical spine trauma assessment显示文摘 | Vincenzo G Concetta G Fabio P | 2004 | Emergency Radiology2004，10，： | 1 |
| 16 | Uncommonly thorough hydrolysis of peptides during ripening of Ragusano cheese revealed by tandem mass spectrometry显示文摘 | VALIRIE G STEFANIA C CONCETTA P | 2011 | Journal of Agricultural and Food Chemistry2011，59，12： | 1 |
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