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1914篇 您的检索式：作者名="Collin T"

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	题名	作者	年代	出处	被引量
1	The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia显示文摘Tumor-induced osteomalacia(TIO) is a rare paraneoplastic syndrome in which ectopic production of fibroblast growth factor 23(FGF23) by non-malignant mesenchymal tumors causes phosphate wasting and bone fractures. Recent studies have implicated the hypoxia-inducible factor-1α(HIF-1α) in other phosphate wasting disorders caused by elevated FGF23, including X-linked hypophosphatemic rickets and autosomal dominant hypophosphatemia. Here we provide evidence that HIF-1α mediates aberrant FGF23 in TIO by transcriptionally activating its promoter. Immunohistochemical studies in phosphaturic mesenchymal tumors resected from patients with documented TIO showed that HIF-1α and FGF23 were co-localized in spindleshaped cells adjacent to blood vessels. Cultured tumor tissue produced high levels of intact FGF23 and demonstrated increased expression of HIF-1α protein. Transfection of MC3T3-E1 and Saos-2 cells with a HIF-1α expression construct induced the activity of a FGF23 reporter construct. Prior treatment of tumor organ cultures with HIF-1α inhibitors decreased HIF-1α and FGF23 protein accumulation and inhibited HIF-1α-induced luciferase reporter activity in transfected cells. Chromatin immunoprecipitation assays confirmed binding to a HIF-1α consensus sequence within the proximal FGF23 promoter, which was eliminated by treatment with a HIF-1α inhibitor. These results show for the first time that HIF-1α is a direct transcriptional activator of FGF23 and suggest that upregulation of HIF-1α activity in TIO contributes to the aberrant FGF23 production in these patients.	Qian Zhang Michele Doucet Ryan E Tomlinson Xiaobin Han L Darryl Quarles Michael T Collins Thomas L Clemens	2016	Bone Research2016，4，2：	6
2	Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘	Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A.	2009	中国神经肿瘤杂志2009，7，4：	3
3	Positron emission tomography scanning in the evaluation of hepatocellular carcinoma显示文摘	M.Akram Khan Connie S Combs Elizabeth M Brunt Val J Lowe Michael K Wolverson Harvey Solomon Brian T Collins Adrian M.Di Bisceglie	2000	Journal of Hepatology2000，，5：	2
4	A practical method for calculating largest Lyapunov exponents in from small data set显示文摘	Rosenstein M T Collins J J De Luca C J	1993	Physica D1993，65，12：	2
5	A practical method for calculating largest Lyapunov exponents from small data sets显示文摘	Rosenstein M T Collins J J Deluca C J	1993	Physica D1993，65，1：	2
6	CD133,a novel marker for human prostatic epithelial stem cells显示文摘	Richardson G D Robson C N Lang S H Neal D E Maitland N J Collins A T	2004	J Cell Sci2004，117，16：	1
7	PPARa activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells显示文摘	Marx N Sukhova GK Collins T	1999	Circulation1999，99，24：	1
8	Strain-independen temperature measurement using a type-land type - ⅡA optical fiber Bragg grating combination显示文摘	S Pal T Sun K T V Grattan S A Wade S F Collins G W Baxter B Dussardier and G Monnom	2004	Rev Sci Instrum2004，75，：	1
9	Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers显示文摘	Read MA Neish AS	1995	FASEB J1995，9，：	1
10	A practical method for calculating largest Lyapunov exponents form small data set显示文摘	Collins J Deluca J	1993	Physics D1993，65，：	1
11	A period stochastic reso- nance in excitable systems显示文摘	Collins J J Chow C C Infiaoff T T	1995	Physics Review E1995，52，3：	1
12	A practical method for calculating largest Lyapunov exponents from small data sets显示文摘	ROSENSTEIN M T COLLINS J J DE LUCA C J	1993	Physica D1993，65，1：	1
13	Regulated expression of endothelin 1 in glomerular capillary endothelial cells显示文摘	Marsden PA Dorfman DM Collins T	1991	Am J Physiol1991，261，12：	1
14	Acquired hemophilia A in the United Kingdom: a 2-year national surveillance study by the United Kingdom Haemophilia Centre Doctors' Organisation显示文摘	COLLINS P W HIRSCH S BAGLIN T P	2007	Blood2007，109，5：	1
15	A practical method for calculating largest Lyapunov exponents from small data sets显示文摘	M T Rosenstein J J Collins C J Deluca	1993	Physica D1993，65，12：	1
16	Isolation of swine infertility and respiratory syndrome virus(isolate ATCC VR-2332)in North America and experimental reproduction of the disease in gno-tobiotic pigs 显示文摘	Collins J E Benfield D A Christianson W T	1992	Journal of Veterinary Diagnostic Investigation1992，4，2：	1
17	Soil carbon pools and fluxes in lung-term corn belt agroeeosystems 显示文摘	COLLINS H P ELLIOTT E T PAUSTIAN K	2000	Soil Biology and Biochemistry2000，32，2：	1
18	Inheritance of glandular trichomes in tobacco显示文摘	Johnson J C Nielsen M T Collins G B	1988	Crop Science1988，28，：	1
19	Online selection of discriminative tracking features显示文摘	Collins R T Liu Y		0，，10：	1
20	A practical method for calculating largest lyapunov exponents from small data sets显示文摘	Rosenstein M T Collins J J De Luca C J	1993	Physics D: Nonlinear Phenomena1993，65，1：	1

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