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80篇 您的检索式:作者名="Coco D"
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1一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas.Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P 2014中华神经外科疾病研究杂志2014,13,5:6
2GPS Satellites of Opportunity for Ionospheric Monitoring显示文摘COCO D 1991Innovation1991,,10:1
3Measuring technological capabilitiesat the country level: a survey and a menu for choice显示文摘ARCHIBUGI D COCO A 2005Research Policy2005,34,2:1
4Fractal behaviour in nearshore processes 显示文摘Coco G Huntley D A O'Hare T 2000American Society of Civil Engineers2000,,276:1
5Hepatitis B surface antigen serum levels help to distinguish active from inactive hepatitis B virus genotype D carriers 显示文摘Brunetto MR Oliveri F Colombatto P Moriconi F Ciccorossi P Coco B Romagnoli V Cherubini B Moscato G Maina AM Cavallone D Bonino F 2010Gastroenterology2010,139,2:1
6A New Indicator of Technological Capabilities for Developed and Developing Countries (Arco)显示文摘Archibugi D Coco A 0,,04:1
7Genetic diagnosis and molecular monitoring in the management of acute promyelocytic leukemia显示文摘Lo Coco F Diverio D Falini B 1999Blood1999,94,1:1
8Measuring technological capabilities at the country level: A survey and a menu for choice 显示文摘ARCHIBUGI D COCO A 2005Forthcoming in Research Policy2005,,:1
9Variability of GPS satellite differential group delay biases显示文摘Coco D S 1991IEEE transaction on aerospace and electrical systems1991,27,6:1
10Genetic Diagnosis and Molecular Monitoring in the Management of Acute Promyelocytic Leukemia显示文摘Coco F L Diverio D Falini B 1999Blood1999,94,1:1
11Fatigue,sleep,and nocturnal complaints in patients with amyotrophic lateral sclerosis显示文摘Lo Coco D La Bella V 2012Eur J Neurol2012,19,5:1
12Rituximab for managing relapsing or refractory patients with idiopathic thrombotic thrombocytopenic purpura-- haemolytic uraemic syndrome 显示文摘Caramazza D Quintini G Abbene I Coco LL Malato A Di Trapani R 2010Blood Transfus2010,8,3:1
13Noninvasive positive-pressure ventilation in ALS:predictors of tolerance and survival显示文摘Lo Coco D Marchese S Peseo MC Neurology0,,:1
14Acute promyelocytic leukemia:a model for the role of molecular diagnosis and residual disease monitoring in directing treatment approach in acute myeloid leukemia显示文摘Grimwade D and Lo Coco F 2002Leukemia2002,16,10:1
15Measuring technological capabilities atthe country level : A survey and a menu for choice 显示文摘AHCHIBUGI D COCO A 2005Research Policy2005,34,2:1
16Fertilizer nitro- gen rates to optimize cotton yield and fiber quality显示文摘Boquet D J Breitenbeck G A Coco A B 1991Louisiana Agriculture1991,35,:1
17GPS satellites of opportunity for ionospheric monitoring显示文摘Coco D 0,,:1
18Therapy of molecular relapse in acute promyelocytic leukemia显示文摘LO COCO F DIVERIO D AVVISATI G et at 1999Blood1999,94,:1
19Genetic diagnosis and molecular monitoring in the management of acute promyelocytic leukemia显示文摘Lo Coco F Diverio D Falini B 1999Blood1999,94,1:1
20Therapy of molecu- lar relapse in acute promyelocytic leukemia显示文摘Lo Coco F Diverio D Avvisati G 1999Blood1999,94,7:1
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