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| 1 | Prediction of the severity of colorectal lesion by fecal hemoglobin concentration observed during previous test in the French screening program显示文摘BACKGROUND The rate of positive tests using fecal immunochemical test(FIT)does not decrease with subsequent campaigns,but the positive predictive value of advanced neoplasia significantly decreases in subsequent campaign after a first negative test.A relationship between the fecal hemoglobin concentration(Fhb)and the opportunity to detect a colorectal cancer in subsequent campaign has been shown.AIM To predict the severity of colorectal lesions based on Fhb measured during previous colorectal cancer screening campaign.METHODS This etiological study included 293750 patients aged 50-74,living in Auvergne-Rhone-Alpes(France).These patients completed at least two FIT[test_((-1))and test_((0))]between June 2015 and December 2019.Delay between test_((-1))and test_((0))was>1year and test_((-1))result was negative(<150 ngHb/mL).The severity of colorectal lesions diagnosed at test_((0))was described according to Fhb measured at test_((-1))[Fhb_((-1))].The relationship between the severity classified in seven ordinal categories and the predictive factors was analyzed in an ordered multivariate polytomous regression model.RESULTS The test_((0))positive rate was 4.0%,and the colonoscopy completion rate was 97.1%in 11594 patients who showed a positive test_((0)).The colonoscopy detection rate was 77.7%in those 11254 patients who underwent a colonoscopy.A total of 8748 colorectal lesions were detected(including 2182 low-risk-polyps,2400 high-riskpolyp,and 502 colorectal cancer).The colonoscopy detection rate varied significantly with Fhb_((-1))[0 ngHb/mL:75.6%,(0-50 ngHb/mL):77.3%,(50-100 ngHb/mL):88.7%,(100-150 ngHb/mL):90.3%;P=0.001].People with a Fhb_((-1))within(100-150 ngHb/mL)(P=0.001)were 2.6(2.2;3.0)times more likely to have a high severity level compared to those having a Fhb_((-1))value of zero.This risk was reduced by 20%in patients aged 55-59 compared to those aged<55[adjusted odds ratio:0.8(0.6;1.0)].CONCLUSION The study showed that higher Fhb_((-1))is correlated to an increased risk of severity of colorectal lesions.This risk of severity increased among first-time participants(age<55)and the elderly(≥70).To avoid the loss of chance in these age groups,the FIT positivity threshold should be reduced to 100 ngHb/mL.The other alternative would be to reduce the time between the two tests in these age groups from the current 2 years to 1 year. | Christian Balamou Akoi Koivogui Christelle M Rodrigue Aurelie Clerc Claire Piccotti Anne Deloraine Catherine Exbrayat | 2021 | World Journal of Gastroenterology2021，27，31： | 2 |
| 2 | Protein-sparing therapy in the postoperative period显示文摘 | Ulrich Keller M.D. Didier Clerc M.D. Marius Kr?nzlin M.D. M. Heberer M.D | 1986 | World Journal of Surgery1986，，1： | 2 |
| 3 | The particle swarm: Explosion, stability, and convergence in a multi-dimensional complex space 显示文摘 | CLERC M KENNEDY J | 2002 | IEEE Transactions on Evolutionary Computation2002，6，1： | 1 |
| 4 | Genomewide Association Study of an AIDS-Nonprogression Cohort Emphasizes the Role Played by HLA Genes (ANRS Genomewide Association Study 02)显示文摘 | Limou S Le Clerc S Coulonges C | 2009 | Journal of Infectious Diseases2009，199，3： | 1 |
| 5 | Labelling with colloidal gold with protein A显示文摘 | Clerc M F | 1985 | Histochemistry1985，82，： | 1 |
| 6 | The particle swarm-explosion, stability, and convergence in a multidimensional complex space 显示文摘 | Clerc M Kennedy J | 2002 | IEEE Transactions on Evolutionary Computation2002，6，1： | 1 |
| 7 | Human mesenchymal stem cells suppress induction of cytotoxic response to alloantigens 显示文摘 | Angoulvant D Clerc A Benchalal S | 2004 | Biorheology2004，41，34： | 1 |
| 8 | A double-blind Comparison of venlafaxine and fluoxetine in patients hospitalized for major depression and melancholia显示文摘 | Clerc GE Ruimy P Verdeau-Palles J | 1994 | Int Clin Psychopharmacol1994，9，： | 1 |
| 9 | The particle swarm-explosion,stability,and convergence in a multidimensional complex space显示文摘 | Clerc M Kennedy J | 2002 | IEEE Transactions on Evolutionary Computation2002，6，1： | 1 |
| 10 | The Particle Swarm-Explosion,Stability,and Convergence in a Multidimensional Complex Space显示文摘 | Maurice Clerc james Kennedy | 2002 | IEEE TRANSACTIONS ON EVOLUTIONARY COMPUTER2002，，： | 1 |
| 11 | The particle swarm-explosion, stability and convergence in a multidimensional complex space显示文摘 | CLERC M KENNEDY J | 2002 | IEEE Transactions on Evolutionary Computation2002，6，1： | 1 |
| 12 | The particle swarm-explosion,stability,and convergence in a multidimensional complex space显示文摘 | Clerc M Kennedy J | 2002 | IEEE Transactions on Evolutionary Computation2002，6，1： | 1 |
| 13 | The particle swarm: explosion, stability, and convergence in multi-dimensional complex space 显示文摘 | Clerc M Kennedy J | 2002 | IEEE Transaction on Evolutionary Computation2002，6，1： | 1 |
| 14 | 'Experimental Study of the Impact of an Ink-Jet Printed Droplet on a Solid Substrate'显示文摘 | Van Dam Dirkjan B Le Clerc Chritophe | 2004 | Physics of Fluids2004，16，9： | 1 |
| 15 | The particle swarm - explosion, stability, and convergence in a multidimensional complex space 显示文摘 | Clerc M Kennedy J | 2002 | IEEE Trans Evolutionary Computation2002，6，1： | 1 |
| 16 | The particle swarm: Explosion,stability and convergence in a multi-dimensional complex space 显示文摘 | Clerc M Kennedy J | 2001 | IEEE J of Evolutionary Computation2001，6，1： | 1 |
| 17 | Influence of talc physical properties on the fire retarding behaviour of (ethylenevinyl acetate copolymer/magnesium hydroxide/talc) composites显示文摘 | Clerc L Ferry L Leroy E | 2005 | Polymer Degradation and Stability2005，88，： | 1 |
| 18 | The Particle Swarm--Explosion, Sta- bility, and Convergence in A Multidimensional Complex Space显示文摘 | Maurice Clerc James Kennedy | 2002 | Evolutionary Computation2002，6，1： | 1 |
| 19 | A simple model to predict the removal of oil suspensions from water u- sing the eleetroeoagulafion technique 显示文摘 | Carmona M Khemis M Jean - Pierre Le- clerc | 2006 | Chem Eng Sci2006，61，： | 1 |
| 20 | The particle swarm-explosion,stability, and convergence in a multidimensional complexspace显示文摘 | CLERC M KENNEDY J | 2002 | IEEE Transactions on Evolutionary Computation2002，6，1： | 1 |
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