|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity显示文摘 | Clement V Sanchez P de Tribolet N Radovanovic I Ruiz i Altaba A | 2007 | 中国神经肿瘤杂志2007，5，2： | 96 |
| 2 | Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis显示文摘The pool of microbes inhabiting our body is known as 'microbiota' and their collective genomes as 'microbiome'. The colon is the most densely populated organ in the human body, although other parts, such as the skin, vaginal mucosa, or respiratory tract, also harbour specific microbiota. This microbial community regulates some important metabolic and physiological functions of the host, and drives the maturation of the immune system in early life, contributing to its homeostasis during life. Alterations of the intestinal microbiota can occur by changes in composition(dysbiosis), function, or microbiota-host interactions and they can be directly correlated with several diseases. The only disease in which a clear causal role of a dysbiotic microbiota has been demonstrated is the case of Clostridium difficile infections. Nonetheless, alterations in composition and function of the microbiota have been associated with several gastrointestinal diseases(inflammatory bowel disease, colorectal cancer, or irritable bowel syndrome), as well as extra-intestinal pathologies, such as those affecting the liver, or the respiratory tract(e.g., allergy, bronchial asthma, and cystic fibrosis), among others. Species of Bifidobacterium genus are the normal inhabitants of a healthy human gut and alterations in number and composition of their populations is one of the most frequent features present in these diseases. The use of probiotics, including bifidobacteria strains, in preventive medicine to maintain a healthy intestinal function is well documented. Probiotics are also proposed as therapeutic agents for gastrointestinal disorders and other pathologies. The World Gastroenterology Organization recently published potential clinical applications for several probiotic formulations, in which species of lactobacilli are predominant. This review is focused on probiotic preparations containing Bifidobacterium strains, alone or in combination with other bacteria, which have been tested in human clinical studies. In spite of extensive literature on and research into this topic, the degree of scientific evidence of the effectiveness of probiotics is still insufficient in most cases. More effort need to be made to design and conduct accurate human studies demonstrating the efficacy of probiotics in the prevention, alleviation, or treatment of different pathologies. | Rafael Tojo Adolfo Suárez Marta G Clemente Clara G de los Reyes-Gavilán Abelardo Margolles Miguel Gueimonde Patricia Ruas-Madiedo | 2014 | World Journal of Gastroenterology2014，20，41： | 33 |
| 3 | Control of malaria and other vector-borne protozoan diseases in the tropics: enduring challenges despite considerable progress and achievements显示文摘Vector-borne protozoan diseases represent a serious public health challenge,especially in the tropics where poverty together with vector-favorable climates are the aggravating factors.Each of the various strategies currently employed to face these scourges is seriously inadequate.Despite enormous efforts,vaccines-which represent the ideal weapon against these parasitic diseases—are yet to be sufficiently developed and implemented.Chemotherapy and vector control are therefore the sole effective attempts to minimize the disease burden.Nowadays,both strategies are also highly challenged by the phenomenon of drug and insecticide resistance,which affects virtually all interventions currently used.The recently growing support from international organizations and governments of some endemic countries is warmly welcome,and should be optimally exploited in the various approaches to drug and insecticide research and development to overcome the burden of these prevalent diseases,especially malaria,leishmaniasis,Human African Trypanosomiasis(HAT),and Chagas disease. | Denis Zofou Raymond B Nyasa Dickson S Nsagha Fidele Ntie-Kang Henry D Meriki Jules Clement N Assob Victor Kuete | 2014 | Infectious Diseases of Poverty2014，3，1： | 4 |
| 4 | Search for a dark photon in the π 0 → e + e ? γ decay显示文摘 | P. Adlarson W. Augustyniak W. Bardan M. Bashkanov F.S. Bergmann M. Ber?owski H. Bhatt A. Bondar M. Büscher H. Calén I. Ciepa? H. Clement D. Coderre E. Czerwiński K. Demmich E. Doroshkevich R. Engels W. Erven W. Eyrich P. Fedorets K. F?hl K. Fransson F. Go | 2013 | Physics Letters B . 2013 (1-3)2013，，1： | 3 |
| 5 | Oral probiotic VSL #3 attenuates the circulatory disturbances of patients with cirrhosis and ascites显示文摘 | Diego Rincón Javier Vaquero Ana Hernando Evelyn Galindo Cristina Ripoll Marta Puerto Magdalena Salcedo Rubén Francés Ana Matilla María V. Catalina Gerardo Clemente José Such Rafael Ba?ares | 2014 | Liver Int2014，，10： | 2 |
| 6 | Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain-a primate study显示文摘 | Hynynen K McDannold N Clement G | 2006 | Eur J Radiol2006，59，2： | 1 |
| 7 | Soluble leptin receptor in serum of subjects with complete resistance to leptin显示文摘 | Lahlou N Clement K Carel JC | 2000 | Diabetes2000，49，8： | 1 |
| 8 | Components of the anti-Müllerian hormone signaling pathway in gonads显示文摘 | Clemente ND Josso N Gouedard L | 2003 | Mol Cell Endocrinol2003，211，1： | 1 |
| 9 | Anti-Mullerian hormone concentrations in the follicular fluid of the preovulatory follicle are predictive of the implantation potential of the ensuing embryo obtained by in vitro fertilization显示文摘 | Fanchin R Mendez LD Frydman N Gougeon A di Clemente N Frydman R Taieb J | 2007 | J Clin Endocrinol Metab2007，92，： | 1 |
| 10 | Incidence and Diversity of Nestyphodium Fungal Endophytes in Tall Fescue from Morocco, Tunisia, and Sardinia显示文摘 | Clement S L Elberson L R Youssef N N | 2001 | Crop Science2001，41，： | 1 |
| 11 | Medicinal herb use among asthmatic patients attending a specialty care facility in Trinidad显示文摘 | Clement Y N Williams A F Aranda D | 2005 | BMC Compl Altern Med2005，5，： | 1 |
| 12 | Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor 显示文摘 | Inagaki N Gonoi T Clement J P 4th | 1995 | Science1995，270，： | 1 |
| 13 | Anti-Mallerian hormone receptor defect显示文摘 | di Clemente N Belville C | 2006 | Best Pract Res Clin Endocrinol Metab2006，20，4： | 1 |
| 14 | Making the Most Out of Programme Evaluations and Social Experiments: Accounting for heterogeneity in Programme Impacts 显示文摘 | Heckman James Jeffrey Smith N Clements | 1997 | Review of Economic Studies1997，64，4： | 1 |
| 15 | A family of sulfonylurea receptors determines the pharmacological properties of ATP-insensitive K+ channels显示文摘 | Inagaki N Gonoi T Clement J P | 1996 | Neuron1996，16，5： | 1 |
| 16 | Interstitial lung diseases in children显示文摘 | Clement A Nathan N Epaud R | | 0，，05： | 1 |
| 17 | A quantitative and interspecific test for biological activity of anti-Müillerian hormone:the fetal ovary aromatase assay显示文摘 | Di Clemente N Ghaffari S Pepinsky R | 1992 | Development1992，114，： | 1 |
| 18 | A mutation in the human leptin receptor gene causes obesity and pituitary dysfunetion显示文摘 | Clement K Vaisse C Lahlou N el al | 1998 | Nature1998，392，： | 1 |
| 19 | , Purification and partial characterizeation of Chickpea 2S albumin显示文摘 | Sa nchez-Vioque R Mille n F Clemente A | 1999 | Journal of Agriculture and Food Chemistry1999，47，： | 1 |
| 20 | Liver imaging with ferumoxides(Feridex): fundamentals,controversies, and practical aspects 显示文摘 | Siauve N Cuenod CA | 1998 | Top Magn Resort Imaging1998，9，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员