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| 1 | Predictors of early and late hepatocellular carcinoma recurrence显示文摘Hepatocellular carcinoma(HCC)is the most frequent liver neoplasm,and its incidence rates are constantly increasing.Despite the availability of potentially curative treatments(liver transplantation,surgical resection,thermal ablation),long-term outcomes are affected by a high recurrence rate(up to 70%of cases 5 years after treatment).HCC recurrence within 2 years of treatment is defined as“early”and is generally caused by the occult intrahepatic spread of the primary neoplasm and related to the tumor burden.A recurrence that occurs after 2 years of treatment is defined as“late”and is related to de novo HCC,independent of the primary neoplasm.Early HCC recurrence has a significantly poorer prognosis and outcome than late recurrence.Different pathogenesis corresponds to different predictors of the risk of early or late recurrence.An adequate knowledge of predictive factors and recurrence risk stratification guides the therapeutic strategy and post-treatment surveillance.Patients at high risk of HCC recurrence should be referred to treatments with the lowest recurrence rate and when standardized to combined or adjuvant therapy regimens.This review aimed to expose the recurrence predictors and examine the differences between predictors of early and late recurrence. | Riccardo Nevola Rachele Ruocco Livio Criscuolo Angela Villani Maria Alfano Domenico Beccia Simona Imbriani Ernesto Claar Domenico Cozzolino Ferdinando Carlo Sasso Aldo Marrone Luigi Elio Adinolfi Luca Rinaldi | 2023 | World Journal of Gastroenterology2023，29，8： | 6 |
| 2 | Ultra-lightweight aluminum foam materials for automotive applications显示文摘 | Yu C-Y Banhart J | 2000 | International Journal of Powder Metallurgy2000，36，： | 1 |
| 3 | Conductivity of porous Ni/ZrO2-Y2O3 cermets显示文摘 | Dees D W Claar T D Easler T E | 1987 | J Electrochem Soc1987，134，9： | 1 |
| 4 | Transverse and Longitudinal Crushing of Aluminum-foam Filled Tubes显示文摘 | Hall I W Guden M Claar T D | 2002 | Seriptamaterialia2002，46，： | 1 |
| 5 | Parental response to children's pain: The moderating impact of children's emotional distress on symptoms and disability 显示文摘 | Claar RL Simons LE Logan DE | 2008 | Pain2008，138，1： | 1 |
| 6 | New life for hydraulicpresses 显示文摘 | Les Claar Al Derouen Bruno Stillhard | 1989 | Engineering and Technology Guide1989，，12： | 1 |
| 7 | Emotional distress and quality of life in caregivers of patients awaiting lung transplant 显示文摘 | Claar RL Parekh PI Palmer SM | 2005 | J Psychosom Res2005，59，1： | 1 |
| 8 | Conductivity of Porous Ni/ZrO2-Y2O3 Cermets显示文摘 | Dees D W Claar T D Easier T E | 1987 | J Electrochemical Soc1987，134，9： | 1 |
| 9 | Conductivity of Porous Ni/ZrO2-Y2O3 cermets 显示文摘 | Claar T D Easler T E | 1987 | J Electrochem Soc1987，134，9： | 1 |
| 10 | Esomeprazole 40mg provides more effective acid control than lansoprazole 30mg显示文摘 | Rohss K Nilsson - Claar C Rydholm H | 2000 | Gastroenterology2000，118，2： | 1 |
| 11 | Treatment of Morbid Obesity and Gastroesophageal Reflux with Hiatal Hernia by Lap-Band显示文摘 | Luigi Angrisani MD Paola Iovino MD Michele Lorenzo MD PhD Tito Santoro MD Francesco Sabbatini MD ChM Ernesto Claar MD Ornella Nicodemi MD Giovanni Persico MD ChM Beniamino Tesauro MD ChM | 1999 | Obesity Surgery1999，，4： | 1 |
| 12 | The influence of appraisals in understanding children's experience with medical procedures显示文摘 | Claar R L walker L S smith C A | 2002 | J Pediatr Psychol2002，27，7： | 1 |
| 13 | Risk Factors for Aspiration Pneumonia in Frail Older People: A Systematic Literature Review显示文摘 | Claar D. van der Maarel-Wierink Jacques N.O. Vanobbergen Ewald M. Bronkhorst Jos M.G.A. Schols Cees de Baat | 2011 | Journal of the American Medical Directors Association2011，，5： | 1 |
| 14 | Boceprevir or telaprevir in hepatitis C virus chronic infection:The Italian real life experience显示文摘AIM: To check the safety and efficacy of boceprevir/telaprevir with peginterferon/ribavirin for hepatitis C virus(HCV) genotype 1 in the real-world settings. METHODS: This study was a non-randomized, observational, prospective, multicenter. This study involved 47 centers in Italy. A database was prepared for the homogenous collection of the data, was used by all of the centers for data collection, and was updated continuously. All of the patients enrolled in this study were older than 18 years of age and were diagnosed with chronic infection due to HCV genotype 1. The HCV RNA testing was performed using COBAS-Taq Man2.0(Roche, LLQ 25 IU/m L). RESULTS: All consecutively treated patients were included. Forty-seven centers enrolled 834 patients as follows: Male 64%; median age 57(range 18-78), of whom 18.3% were over 65; mean body mass index 25.6(range 16-39); genotype 1b(79.4%); diagnosis of cirrhosis(38.2%); and fibrosis F3/4(71.2%). The following drugs were used: Telaprevir(66.2%) and PEG-IFN-alpha2a(67.6%). Patients were na?ve(24.4%), relapsers(30.5%), partial responders(14.8%) and null responders(30.3%). Overall, adverse events(AEs) occurred in 617 patients(73.9%) during the treatment. Anemia was the most frequent AE(52.9% of cases), especially in cirrhotic. The therapy was stopped for 14.6% of the patients because of adverse events or virological failure(15%). Sustained virological response was achieved in 62.7% of the cases, but was 43.8% in cirrhotic patients over 65 years of age. CONCLUSION: In everyday practice, triple therapy is safe but has moderate efficacy, especially for patients over 65 years of age, with advanced fibrosis, nonresponders to peginterferon + ribavirin. | Antonio Ascione Luigi Elio Adinolfi Pietro Amoroso Angelo Andriulli Orlando Armignacco Tiziana Ascione Sergio Babudieri Giorgio Barbarini Michele Brogna Francesco Cesario Vincenzo Citro Ernesto Claar Raffaele Cozzolongo Giuseppe D’Adamo Emilio D’Amico Pellegrino Dattolo Massimo De Luca Vincenzo De Maria Massimo De Siena Giuseppe De Vita Antonio Di Giacomo Rosanna De Marco Giorgio De Stefano Giulio De Stefano Sebastiano Di Salvo Raffaele Di Sarno Nunzia Farella Laura Felicioni Basilio Fimiani Luca Fontanella Giuseppe Foti Caterina Furlan Francesca Giancotti Giancarlo Giolitto Tiziana Gravina Barbara Guerrera Roberto Gulminetti Angelo Iacobellis Michele Imparato Angelo Iodice Vincenzo Iovinella Antonio Izzi Alfonso Liberti Pietro Leo Gennaro Lettieri Ileana Luppino Aldo Marrone Ettore Mazzoni Vincenzo Messina Roberto Monarca Vincenzo Narciso Lorenzo Nosotti Adriano Maria Pellicelli Alessandro Perrella Guido Piai Antonio Picardi Paola Pierri Grazia Pietromatera Francesco Resta Luca Rinaldi Mario Romano Angelo Rossini Maurizio Russello Grazia Russo Rodolfo Sacco Vincenzo Sangiovanni Antonio Schiano Antonio Sciambra Gaetano Scifo Filomena Simeone Annarita Sullo Pierluigi Tarquini Paolo Tundo Alfredo Vallone | 2016 | World Journal of Hepatology2016，8，22： | 1 |
| 15 | The influence of appraisals in understanding children's experience with medical procedures显示文摘 | Claar RL Walker LS Smith CA | 2002 | J Pediatr Psychol2002，27，7： | 1 |
| 16 | New life for hydrau lic presses 显示文摘 | Les Claar Al Derouen Bruno Stillhard | 1989 | Engneering and Technology Guide1989，，12： | 1 |
| 17 | OralHealth Care and Aspiration Pneumonia in Frail Older People:A Systematic Literature Review 显示文摘 | Claar D van der Maarel - Wierink Jackie NO | 2013 | Gerodontology2013，30，1： | 1 |
| 18 | Esomeprazole 40 mg provides more effective acid control than lansoprazole 30 mg 显示文摘 | Rhss K Nilsson - Claar C Rydholm H | 2000 | Gastroenterology2000，118，2： | 1 |
| 19 | Conductivity of porous Ni/ZrO2-Y2O3 cermets显示文摘 | Dees D W Claar T D Easler T E | 1987 | Electrochem Soc1987，134，9： | 1 |
| 20 | New life for hydraulic presses显示文摘 | LES Claar AL Derouen BRUNO Stillhard | 1989 | Engineering and Technology Guide1989，，12： | 1 |
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