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| 1 | Endothelial Dysfunction and Increased Responses to Renal Nerve Stimulation in Rat Kidneys during Rhabdomyolysis-Induced Acute Renal Failure: Role of Hydroxyl Radical显示文摘 | Onur Cil Mert Ertunc Kadri Safak Gucer Fatih Ozaltin Alper Bektas Iskit Rustu Onur | 2012 | Renal Failure2012，，2： | 1 |
| 2 | Experimental study of the effect of ni-tric oxide inhibition on mesenteric blood flow and interleukin-10 levels witha lipopolysaccharide challenge显示文摘 | Baykal A Kavuklu B Iskit AB | 2000 | World J Surg2000，24，9： | 1 |
| 3 | Effects of endothelin and nitric oxide on organ injury, mesenteric ischemia, and survival in experimental models of septic shock显示文摘 | Iskit AB Guc O | 2003 | Acta Pharmaeol Sin2003，24，10： | 1 |
| 4 | The effect of ketamine on acute muscular ischaemia reperfusion in rats显示文摘 | A. E. Salman D. Dal M. A. Salman A. B. Iskit ü Aypar | 2005 | European Journal of Anaesthesiology2005，，9： | 1 |
| 5 | Testicular biopsy during orchiddopexy procedure:does it have an adverse effect on fertility显示文摘 | Iskit SH Tutepe H Tugay M | 2005 | Urol Int2005，75，3： | 1 |
| 6 | Experimental study of the effect of nitric oxide inhibition on mesenteric blood flow and interleukin-10 levels with a lipopolysaecharide challenge显示文摘 | Baykal A Kavuklu B Iskit AB | | 0，，： | 1 |
| 7 | Effects of endothelin and nitric oxide on organ injury,mesenteric ischemia,and survival in experimental models of septic shock显示文摘 | Iskit AB Guc O | 2003 | Acta Pharmacol Sin2003，24，10： | 1 |
| 8 | Chitosan delivery systems for the treatment of oral mucositis:in vitro and in vivo studies显示文摘 | Aksungur P Sungur A Unal S Iskit A B Squier C A Senel S | 2004 | J Control Release2004，98，2： | 1 |
| 9 | Analysis of 33 pediatric trauma victims in the 1999 Marmara,Turkey earthquake显示文摘 | Iskit SH Alpay H Tugtepe H | 2001 | J Pediatr Surg2001，36，2： | 1 |
| 10 | Effects of endothelin and nitric oxide on organ injury, mesenteric ischemia, and survival in experimental models of septic shock 显示文摘 | Iskit AB Guc O | 2003 | Acta Pharmacol Sin2003，24，10： | 1 |
| 11 | Integration of a prob-lem - based multidisciplinary clinical cancer management course into undergraduate education显示文摘 | Abacioglu U Sarikaya O Iskit S | | 0，，： | 1 |
| 12 | Ventilator-associated pneumonia caused by high risk microorganisms:a matched case-control study显示文摘 | Aybar Türkoglu M Topeli Iskit A | 2008 | Tuberk Toraks2008，56，2： | 1 |
| 13 | Effects of endothelin and nitric oxide on organ injury, mesenteric ischemia, and survival in experimental models of septic shock显示文摘 | Iskit AB Guc O | 2003 | Acta Pharmacol Sin2003，24，10： | 1 |
| 14 | Effects of endothelin and nitric oxide on organ injury,mesenteric ischemia,and survival in experimental models of septic shock显示文摘 | Iskit AB Guc O | 2003 | Acta Pharmacol Sin2003，24，10： | 1 |
| 15 | 内皮素和一氧化氮对脓毒性休克实验模型中器官损伤,肠系膜缺血和存活的影响(英文)显示文摘The development of potent drugs to treat cardiopulmonary failure in sepsis, such as antibiotics and new immunomodulatory therapeutic approaches have not prevented sepsis from being a major health problem. Dysfunction of the vascular endothelium is an early event in septic shock. The recognition of endothelium-derived substances, such as nitric oxide and endothelin, important mediators of systemic inflammatory response syndrome,led to the proposal that pharmacological inhibition of nitric oxide and endothelin production could represent a useful strategy in the treatment of septic shock. Splanchnic ischemia and translocation of endotoxin from the gut to the circulation contributes significantly to the high mortality rate in sepsis-related syndromes. This vasoconstriction in the splanchnic circulation can be partially blocked by inducible nitric oxide synthase inhibitor aminoguanidine or endothelin receptor antagonist bosentan in experimental models of septic shock. It can be suggested that endothelin and nitric oxide may affect survival. Although septic shock is a highly complex pathophysiological state, the course of septic shock has different phases with different characteristics which need different (special) treatment strategy. The inhibition of nitric oxide production during hyperdynamic,earlier phase of sepsis combined with the blockade of endothelin receptors at a later stage during the hypodynamic,late phase appears to be a novel promising strategy for the therapy of septic shock. The aim of this review is to discuss the role of nitric oxide and endothelin in sepsis and the potential therapeutic implications of blockade of nitric oxide and endothelin as a target in treatment of human septic shock. Briefly the importance of timing of intervention is also emphasized. | Alper B ISKIT Oguz GUC | 2003 | Acta Pharmacologica Sinica2003，24，10： | 1 |
| 16 | Ventilator- associated pneumonia caused by high risk microorganisms: a matched case-control study显示文摘 | AYBAR TORKOGLU M TOPELI ISKIT A | 2008 | Tuberk Toraks2008，56，2： | 1 |
| 17 | The effect of vitamin D prophylaxis on radiation induced pulmonary damage显示文摘 | Yazici G Yildiz F Iskit A | 2011 | J Radiat Res2011，52，： | 1 |
| 18 | Effects of endothelin and nitric oxide on organ injury, mesenteric ischemia, and survival in experimental models of septic shock 显示文摘 | Iskit A B Guc O | 2003 | Acta Pharmacol Sin2003，24，10： | 1 |
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