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| 1 | Proteolytic processing of SDF-1α by matrix metalloproteinase-2 impairs CXCR4 signaling and reduces neural progenitor cell migration显示文摘Neural stem cells and neural progenitor cells(NPCs)exist throughout life and are mobilized to replace neurons,astrocytes and oligodendrocytes after injury.Str-omal cell-derived factor 1(SDF-1,now named CXCL12)and its receptor CXCR4,an α-chemokine receptor,are critical for NPC migration into damaged areas of the brain.Our previous studies demonstrated that immune activated and/or HIV-1-infected human monocyte-derived-macrophages(MDMs)induced a substantial increase of SDF-1 production by human astrocytes.However,matrix metalloproteinase(MMP)-2,a protein up-regulated in HIV-1-infected macrophages,is able to cleave four amino acids from the N-terminus of SDF-1,resulting in a truncated SDF-1(5-67).In this study,we investigate the diverse signaling and function induced by SDF-1α and SDF-1(5-67)in human cortical NPCs.SDF-1(5-67)was generated by incubating human recombinant SDF-1α with MMP-2 followed by protein determination via mass spectrometry,Western blotting and ELISA.SDF-1α induced time-dependent phosphorylation of extracellular signal-regulated kinases(ERK)1/2,Akt-1,and diminished cyclic adenosine monophosphate(cAMP).In contrast,SDF-1(5-67)failed to induce these signaling.SDF-1α activation of CXCR4 induced migration of NPCs,an effect that is dependent on ERK1/2 and Akt-1 pathways;whereas SDF-1(5-67)failed to induce NPC migration.This observation provides evidence that MMP-2 may affect NPC migration through post-translational processing of SDF-1α. | Hui Peng Yumei Wu Zhiyuan Duan Pawel Ciborowski Jialin C.Zheng | 2012 | Protein & Cell2012，3，11： | 3 |
| 2 | Role of Staphylococcus protein in the development of influenza pneumonia显示文摘 | Tashiro P Ciborowski H D Pulverer K G | 1987 | Nature1987，325，： | 1 |
| 3 | Metabolomic approach with LC-MS reveals significant effect of pressure on diver’s plasma显示文摘 | Ciborowski M Javier Rupérez F Martínez-Alcázar MP | 2010 | J Proteome Res2010，9，8： | 1 |
| 4 | Estimation of the uptake of organochlorines by the mayfly Hexagenia limbata ( Ephemeroptera: Ephemeridae) 显示文摘 | Drouillard K G Ciborowski J J H Lazar R | 1996 | Journal of Great Lakes Research1996，22，1： | 1 |
| 5 | Proteomics biomarkers for non-small cell lung cancer显示文摘 | Kisluk J Ciborowski M Niemira M | 2014 | J Pharm Biomed Anal2014，101，： | 1 |
| 6 | “Headiness” or “intelligence” for baseball in the collegiate athlete显示文摘 | Ciborowski T | 1995 | Percept Mot Skills1995，81，3： | 1 |
| 7 | Non-glycosylated tandem repeats of MUC1 facilitate attachment of breast tumor cells to normal human lung tissue and immobilized extracellular matrix proteins (ECM) in vitro:potential role in metastasis显示文摘 | Ciborowski P Finn OJ | | 0，，4： | 1 |
| 8 | Ciborowski Biomarker discov-ery and clinical proteomics显示文摘 | Silberring J Ciborowski P | | 0，，02： | 1 |
| 9 | Proteomic analyses associate cystatin B with restricted HIV-I replication in placental macrophages 显示文摘 | Luciano-Montalvo C Ciborowski P Duan F | 2008 | Placenta2008，29，12： | 1 |
| 10 | Role of staphylococcus protease in the development of influenza pneumonia显示文摘 | Tashiro M Ciborowski P Klenk HD | 1987 | Nature1987，325，： | 1 |
| 11 | Non-glycosylated tandem repeats of MUG1 facilitate attachment of breast tumor cells to normal lung tissue and immobilized extracellular matrix proteins (ECM) in vitro: Potential role in metastasis显示文摘 | Ciborowski P Fimmo J | 2002 | Clln Exp Metastasis2002，19，33： | 1 |
| 12 | Non-glycosylated tandem repeats of MUC1 facilitate attachment of breast tumor cells to normal human lung tissue and immobilized extracellular matrix proteins (ECM) in vitro: Potential role in metastasis显示文摘 | Pawel Ciborowski Olivera J. Finn | 2002 | Clinical and Experimental Metastasis2002，，4： | 1 |
| 13 | Role of Staphylococcus protein in the development of influenza pneumonia显示文摘 | Tashiro P Ciborowski H D Pulverer K G | 1987 | Nature1987，325，： | 1 |
| 14 | Immunological response to a Staphylococcus aureus fibronectin-binding protein显示文摘 | | 1992 | J Med Microbiol1992，37，6： | 1 |
| 15 | Metabolo- mics with LC-QTOF-MS permits the prediction of disease stage in aortic abdominal aneurysm based on plasma metabolic fingerprint显示文摘 | Ciborowski M Teul J Martin-Ventura J L | 2012 | PLoS One2012，7，31： | 1 |
| 16 | Intercellular and intracellular events following the MI-IC-urtrestricted TCR recognition of a tumor-specific pepdde epitope on the epithelial antigen MUCI显示文摘 | Magarian-Blander J Ciborowski P Hsia S | 1998 | Journal of Immunology1998，160，7： | 1 |
| 17 | Investigating the human immunodeficiency virus type 1-infected monocyte-derived macrophage secretome 显示文摘 | Ciborowski P Kadiu I Rozek W | 2007 | Virology2007，363，1： | 1 |
| 18 | Proteomic fingerprinting of HIV-1-infected human monocyte-derived macrophages: a preliminary report显示文摘 | Carlson K A Ciborowski P Schellpeper C N | 2004 | J Neuroimmunol2004，147，12： | 1 |
| 19 | The mechanism of unresponsiveness to circulating tumor antigen MUC1 is a block in intracellular sorting and processing by dendritic cells显示文摘 | Vlad AM Ciborowski P | 2000 | J Immunol2000，165，7： | 1 |
| 20 | A measurement of the ratio of the nucleon structure function in copper and deuterium显示文摘 | J. Ashman B. Badelek G. Baum J. Beaufays C. P. Bee C. Benchouk I. G. Bird S. C. Brown M. C. Caputo H. W. K. Cheung J. S. Chima J. Ciborowski R. Clifft G. Coignet F. Combley G. Court G. d’Agostini J. Drees M. Düren N. Dyce A. W. Edwards M. Edwards T. Ernst | 1993 | Zeitschrift für Physik C Particles and Fields1993，，2： | 1 |
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