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| 1 | Dual stimuli-responsive polyurethane-based hydrogels as smart drug delivery carriers for the advanced treatment of chronic skin wounds显示文摘The design of multi-stimuli-responsive vehicles for the controlled and localized release of drugs is a challenging issue increasingly catching the attention of many research groups working on the advanced treatment of hard-to-close wounds.In this work,a thermo-and pH-responsive hydrogel(P-CHP407)was prepared from an ad hoc synthesized amphiphilic poly(ether urethane)(CHP407)exposing a significant amount of-COOH groups(8.8±0.9 nmol/g_(polymer)).The exposure of acid moieties in P-CHP407 hydrogel led to slightly lower initial gelation temperature(12.1◦C vs.14.6◦C,respectively)and gelation rate than CHP407 hydrogel,as rheologically assessed.Nanoscale hydrogel characterization by Low Field NMR(LF-NMR)spectroscopy suggested that the presence of carboxylic groups in P-CHP407 caused the formation of bigger micelles with a thicker hydrated shell than CHP407 hydrogels,as further proved by Dynamic Light Scattering analyses.In addition,P-CHP407 hydrogel showed improved capability to change its internal pH compared to CHP407 one when incubated with an alkaline buffer(pH 8)(e.g.,pH_(change_5min)=3.76 and 1.32,respectively).Moreover,LF-NMR characterization suggested a stronger alkaline-pH-induced interaction of water molecules with micelles exposing-COOH groups.Lastly,the hydrogels were found biocompatible according to ISO 10993 and able to load and release Ibuprofen:delivery kinetics of Ibuprofen was enhanced by P-CHP407 hydrogels at alkaline pH,suggesting their potential use as smart delivery systems in the treatment of chronic infected wounds. | Rossella Laurano Monica Boffito Michela Abrami Mario Grassi Alice Zoso Valeria Chiono Gianluca Ciardelli | 2021 | Bioactive Materials2021，6，9： | 3 |
| 2 | Reactivity of NO/NO 2 –NH 3 SCR system for diesel exhaust aftertreatment: Identification of the reaction network as a function of temperature and NO 2 feed content显示文摘 | Cristian Ciardelli Isabella Nova Enrico Tronconi Daniel Chatterjee Brigitte Bandl-Konrad Michel Weibel Bernd Krutzsch | 2006 | Applied Catalysis B, Environmental2006，，1： | 2 |
| 3 | Exprimental campaigns on textile wastewater for reuse by means of different membrane processes显示文摘 | MARCUCCI M CIARDELLI G MATTEUCCI A | 2002 | Desalination2002，149，123： | 1 |
| 4 | New fluorinated acrylic polymers for improving weather ability of building stone materials显示文摘 | Ciardelli F Aglietto M Montagnini di Mirabello L | 1997 | Progress in Organic Coatings1997，32，14： | 1 |
| 5 | 查看详情显示文摘 | Silvestri D Barbani N Cristallini C Giusti P Ciardelli G | | 0，，： | 1 |
| 6 | Exprimental campaigns on textile wastewater for reuse by means of different membrane processes显示文摘 | Marcucci M Ciardelli G Matteucci A | 2002 | Desalination2002，149，： | 1 |
| 7 | Immune system develop- ment in infants born to mothers with autoimmune disease, ex- posed in utero to immunosuppressive agents 显示文摘 | Motta M Ciardelli L Marconi M | 2007 | Am J Perinatol2007，24，8： | 1 |
| 8 | Optically Active Polymers of 1-Alkynes显示文摘 | CIARDELLI F LANZILLO S PIERONI O | 1974 | Macromolecules1974，7，： | 1 |
| 9 | Form homogenepus to supported metallocene catalysts 显示文摘 | Ciardelli F Altomare A Michelotti M | 1998 | Catalysis Today1998，41，13： | 1 |
| 10 | Membrane Separation for Wastewater Reuse in the Textile Industry显示文摘 | Ciardelli G Corsi L Marucci M | 2000 | Resour Conserv Recycl2000，31，： | 1 |
| 11 | Membrane separation for wastewater reuse in the textile industry显示文摘 | Ciardelli G Corsi L Marucci M | 2001 | Resources Conservation & Recycling2001，31，2： | 1 |
| 12 | 显示文摘 | Angelina Altomamare Francesco Ciardelli Giada Faralli Synthesis of Reactive Polymeric dyes as Textile Auxiliaries Macromolecular Materials Engineering | 2003 | 288-6792003，，： | 1 |
| 13 | Supported imprinted nanospheres for the selective recognition of cholesterol显示文摘 | Ciardelli G Borrelli C Siivestri D | 2006 | Biosens Bioelectron2006，21，12： | 1 |
| 14 | The treatment and reuse of wastewater in the textile industry by means of ozonation and electroflocculation显示文摘 | Ciardelli G Ranieri N | 2001 | Wat Res2001，35，2： | 1 |
| 15 | Effect of gen- eral and epidural anaesthesia on thyroid hormones and im- munity in neonates显示文摘 | Gasparoni A Ciardelli L De Amiei D | 2008 | Paediatr anaesth2008，12，： | 1 |
| 16 | NH3-SCR of NO Over a V-Based Catalyst: Low-T Redox Kinetics With NH3 Inhibition 显示文摘 | Nova I Ciardelli C Tronconi E | 2006 | AIChE Journal2006，52，9： | 1 |
| 17 | From homogeneous to supported metaUocene catalysts显示文摘 | Ciardelli F Altomare A Michelotti M | | 0，，1： | 1 |
| 18 | Agerelated changes in intracellular Th1/Th2 cytokine production,immunoproliferative T lymphocyte response and natural killer cell activity in newborns,children and adults 显示文摘 | GASPARONI A CIARDELLI L AVANZINI A | 2003 | Biol Neonate2003，84，： | 1 |
| 19 | Blends of poly-(epsilon-eaprolactone) and polysaecharides in tissue engineering applications 显示文摘 | CIARDELLI G CHIONO V VOZZI G | 2005 | Biomacromolecules2005，6，4： | 1 |
| 20 | Experimental campaigns on textile wastewater for reuse by means of different membrane process显示文摘 | MARCUCCI M CIARDELLI G MATTEUCCI A | 2002 | Desalination2002，149，2： | 1 |
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