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| 1 | Polymorphisms in PPARD,PPARG and APM1 associated with four types of Traditional Chinese Medicine constitutions显示文摘Based on the theory of constitution of Traditional Chinese Medicine (TCM), the human population is divided into nine constitutions including one balanced constitution (Normality) and eight unbalanced constitutions (Yang-deficiency, Yin-deficiency, Phlegm-wetness, Qi-deficiency, Wetness-heat, Blood stasis, Depressed constitution, and Inherited special constitution). Different constitutions have specific metabolic features and different susceptibility to certain diseases. However, whether a genetic basis accounts for such constitution classifica-tion is yet to be determined. Here we performed a genetic study to assess the association between genetic variations of metabolic genes in-cluding PPARD, PPARG and APM1 and the constitutions. A total of 233 individuals of the Han population in China were classified into four groups, Normality, Yang-deficiency, Yin-deficiency and Phlegm-wetness with whom 23 single nucleotide polymorphisms (SNPs) in the three genes were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Biased distri-bution of PPARD rs2267669 and rs2076167, APM1 rs7627128 and rs1063539 in Yang-deficiency, PPARG Pro12Ala in Yin-deficiency and PPARD rs2076167, APM1 rs266729 and rs7627128 in Phlegm-wetness were observed. The frequencies of Haplotype13 (Hap13) of PPARG in Yin-deficiency, Hap25 of APM1 in Yang-deficiency and Hap2 of PPARD and Hap14 of PPARG in Phlegm-wetness, were significantly different from those in Normality, suggesting those might be group-associated haplotypes. These results suggested that single SNP and hap-lotypes of PPARD, PPARG and APM1 may underlie the genetic basis of the constitutions classified in TCM. | Yanrui Wu Yina Cun Jing Dong Jingru Shao Shengjun Luo Shengjie Nie Haijing Yu Bingrong Zheng Qi Wang Chunjie Xiao | 2010 | Journal of Genetics and Genomics2010，37，6： | 36 |
| 2 | Sediment-hosted Pb-Zn Deposits in Southwest Sanjiang Tethys and Kangdian Area on the Western Margin of Yangtze Craton显示文摘Yangtze Craton 的西方的边缘作为重要招待沉积的基础金属的总数簇被知道,特别为在中国的 PbZn 存款,例如 Jinding, Daliangzi, Tianbaoshan, Kuangshanchang 和 Qinlinchang 存款。与在世界上的经典 MVT 存款比较,基于招待沉积的 Pb-Zn 存款的基本地质学,这份报纸集中于这存款的 temporalspatial 分发进一步讨论它的大规模矿化作用和构造进化历史。在 SW Sanjiang Thethys, Jinding 沉积物典型地在沙岩和忍受角砾岩的沙岩主要是控制差错、招待的戳,而 MVT 类型存款被岩性学控制并且为招待碳酸盐的岩石与强壮的偏爱差错 / 破裂。最重要地, Jinding PbZn 沉积物不同于它在一个大陆人碰撞地区以内在强烈使变形的低岬盆在被形成的招待沉积的 PbZn 存款的另外的类型。在 Kangdian 区域,招待沉积的 PbZn 存款沿着 Yangtze Craton 在大陆人 orogenic 带的方面上在 extensional 盆被形成。与经典 MVT 存款相比,在 Kangdian 区域的 PbZn 存款属于 MVT 存款。这份报纸是重要的不仅因为招待沉积的 PbZn 的开始的解释扔而且因为利用大贱金属在大沉积目标区域扔。 | WANG Changming DENG Jun ZHANG Shouting XUE Chunji YANG Liqiang WANG Qingfei SUN Xiang | 2010 | Acta Geologica Sinica(English Edition)2010，84，6： | 33 |
| 3 | Effects of cadmium stress on seed germination and seedling growth of Elymus dahuricus infected with the Neotyphodium endophyte显示文摘Various cadmium(Cd)concentrations(0,50,100,200 and 300μmol L-1)affected Elymus dahuricus seed germination,seedling growth,antioxidative enzymes activities(AEA),and amounts of malondialdehyde(MDA)and proline present.These influences were determined for separate E.dahuricus cohorts known to be either infected(E+)or non-infected(E?)by a Neo-typhodium endophyte.Under high Cd concentrations(100,200 and 300μmol L-1),E+specimens showed a significantly (P<0.05)higher germination rate and index,as well as higher values for shoot length,root length and dry biomass.However, the germination rate and index,root length and dry weight did not show a significant(P<0.05)difference under the low Cd concentrations(0 and 50μmol L-1 ).AEA and proline content increased,as did MDA content,in the E+(vs.E-)specimens under high Cd concentrations.There was no significant(P>0.05)difference under low Cd concentrations.Endophyte infection was concluded to be of benefit to E.dahuricus exposed to high Cd concentrations. | ZHANG XingXu LI ChunJie NAN ZhiBiao | 2012 | Science China(Life Sciences)2012，55，9： | 25 |
| 4 | Helium,Argon,and Xenon Isotopic Compositions of Ore-forming Fluids in Jinding-Baiyangping Polymetallic Deposits,Yunnan,Southwest China显示文摘The Jinding superlarge lead and zinc deposit has attracted the attention of geologists of the world and itsmetal logenesis has long been in dispute. This paper takes the Jinding deposit and the Baiyangping Cu-Ag-Co deposit which was recently found at about 30 km north of Jinding as one ore belt, and, based on researches on the helium, argon, and xenon isotopic compositions of primary inclusions in ore-forming solutions of the main stage, the authors have found that the 3He/4He ratio of the ore-forming fluid is 2.7×10-6 (varying from 0.19 to 1.97 Ra), the 4He/40Ar ratio (0.24-3.12) is close to the mantle characteristic ratio, and the xenon isotopic composition and evolution show characters of the mantle xenon. The above results reveal the characteristics of mantle source and crust-mantle fluid mixing (mantle helium reaching 32%) and the metallogenic contributions of the deep processes in the Jinding-Baiyangping ore belt. | XUE Chunji WANG Denghong CHEN Yuchuan YANG Jianmin YANG Weiguang | 2000 | Acta Geologica Sinica(English Edition)2000，74，3： | 17 |
| 5 | Effects of cutting frequency and height on alkaloid production in endophyte-infected drunken horse grass (Achnatherum inebrians)显示文摘An evaluation was performed on the influence of mowing height (2.5,5.0 or 7.5 cm) and mowing frequency (weekly or fortnightly) on levels of ergot alkaloids (ergine and ergonovine) formed in drunken horse grass,Achnatherum inebrians,grown under greenhouse conditions.Samples were taken monthly and alkaloids were extracted and analyzed by reverse-phase HPLC.Alkaloid levels increased more or less linearly with plant age over the first four months following establishment.Levels were higher in samples cut fortnightly compared to those cut weekly,and were higher when plants were cut at a mowing height of 7.5 cm vs.2.5 cm.In most cases,the highest alkaloid levels observed were almost three times those of the lowest.If plant protection applications are developed for the endophytic fungus,Neotyphodium gansuense,it will be necessary to be aware of the potential role of plant husbandry practices (e.g.,defoliation frequency and intensity) for reducing or enhancing levels of plant alkaloids.Similar husbandry factors may affect alkaloid levels in other Neotyphodium-grass associations,which would be interesting for further study. | ZHANG XingXu LI ChunJie NAN ZhiBiao | 2011 | Science China(Life Sciences)2011，54，6： | 13 |
| 6 | Effects of hydrocarbon generation on fluid flow in the Ordos Basin and its relationship to uranium mineralization显示文摘诺思中国的 Ordos 盆是不仅一个重要的铀矿化作用省,而且在中国的油,气体和煤的一个主要制片人。在铀矿化作用和烃之间的基因关系被认出了由很多以前的研究,而是它很好没以盆液体的水动力学被理解流动。我们在以前的研究证明了在 Ordos 侏罗记节的上面的部分的白垩纪铀矿化作用的优先的本地化可能与在向上的流动之间的接口有关,减少液体并且向下流动,氧化液体。这个接口可能被在与不平衡沉积压缩有关的液体过压之间的相互影响控制了并且它驾驶了向上的流动,和地志的地势,它开车了向下流动。在这研究,我们执行了为对液体过压的发展的油和煤气的产生的贡献的数字建模,除了沉积压缩并且加热。当烃产生没被考虑时,我们的结果显示当烃产生被考虑时,液体过压非常与模拟比较在白垩纪期间被加倍。而且,在沉积的结束的液体过压驱散相对没有烃产生盒子慢下来。这些结果建议烃产生可能在铀矿化作用,不是仅仅在规定减少为矿化作用要求的代理人,而且在贡献驱动力维持向上的流动起了一个重要作用。 | Chunji Xue Guoxiang Chi Wei Xue | 2011 | Geoscience Frontiers2011，2，3： | 12 |
| 7 | Seasonal dynamics of suprapermafrost groundwater and its response to the freeing-thawing processes of soil in the permafrost region of Qinghai-Tibet Plateau显示文摘The suprapermafrost groundwater in permafrost region not only is an important component of the water cycle and land surface process, but also is closely associated with the charges of ecological environment in cold region. However, the seasonal dynamics, driving factors, and mechanism of suprapermafrost groundwater are not well understood. Based on observation at slope scale on suprapermafrost groundwater dynamics of typical alpine meadows in the Qinghai-Tibet Plateau, the seasonal dynamics, spatial distribution and driving factors of suprapermafrost groundwater were analyzed. The results showed that there were close relationships between the seasonal dynamics of suprapermafrost groundwater and the freezing-thawing processes of active soil in permafrost region. The seasonal dynamics of suprapermafrost groundwater and its slope distribution pattern were controlled by soil temperature of active layers. The phase and range of the suprapermafrost groundwater dynamics are determined by deep soil(below 60 cm depth) moisture and groundwater recharging sources. The relationship between active soil temperatures and dynamics of suprapermafrost groundwater levels was better described by Boltzmann functions. However, the influencing thresholds of soil temperature on groundwater dynamics varied at different depths of active layers and in different slope positions, which resulted in the significant spatial heterogeneity of suprapermafrost groundwater dynamics in slope scale. Land cover change and global warming certainly altered the dynamics of suprapermafrost groundwater and the hydraulic interaction between groundwater and rivers, and consequently altered the overall hydrologic cycle of watershed scale. | CHANG Juan WANG GenXu LI ChunJie MAO TianXu | 2015 | Science China Earth Sciences2015，58，5： | 12 |
| 8 | Carbon pools and fluxes in the China Seas and adjacent oceans显示文摘The China Seas include the South China Sea, East China Sea, Yellow Sea, and Bohai Sea. Located off the Northwestern Pacific margin, covering 4700000 km^2 from tropical to northern temperate zones, and including a variety of continental margins/basins and depths, the China Seas provide typical cases for carbon budget studies. The South China Sea being a deep basin and part of the Western Pacific Warm Pool is characterized by oceanic features; the East China Sea with a wide continental shelf, enormous terrestrial discharges and open margins to the West Pacific, is featured by strong cross-shelf materials transport; the Yellow Sea is featured by the confluence of cold and warm waters; and the Bohai Sea is a shallow semiclosed gulf with strong impacts of human activities. Three large rivers, the Yangtze River, Yellow River, and Pearl River, flow into the East China Sea, the Bohai Sea, and the South China Sea, respectively. The Kuroshio Current at the outer margin of the Chinese continental shelf is one of the two major western boundary currents of the world oceans and its strength and position directly affect the regional climate of China. These characteristics make the China Seas a typical case of marginal seas to study carbon storage and fluxes. This paper systematically analyzes the literature data on the carbon pools and fluxes of the Bohai Sea,Yellow Sea, East China Sea, and South China Sea, including different interfaces(land-sea, sea-air, sediment-water, and marginal sea-open ocean) and different ecosystems(mangroves, wetland, seagrass beds, macroalgae mariculture, coral reefs, euphotic zones, and water column). Among the four seas, the Bohai Sea and South China Sea are acting as CO_2 sources, releasing about0.22 and 13.86–33.60 Tg C yr^(-1) into the atmosphere, respectively, whereas the Yellow Sea and East China Sea are acting as carbon sinks, absorbing about 1.15 and 6.92–23.30 Tg C yr^(-1) of atmospheric CO_2, respectively. Overall, if only the CO_2 exchange at the sea-air interface is considered, the Chinese marginal seas appear to be a source of atmospheric CO_2, with a net release of 6.01–9.33 Tg C yr^(-1), mainly from the inputs of rivers and adjacent oceans. The riverine dissolved inorganic carbon (DIC) input into the Bohai Sea and Yellow Sea, East China Sea, and South China Sea are 5.04, 14.60, and 40.14 Tg C yr^(-1),respectively. The DIC input from adjacent oceans is as high as 144.81 Tg C yr^(-1), significantly exceeding the carbon released from the seas to the atmosphere. In terms of output, the depositional fluxes of organic carbon in the Bohai Sea, Yellow Sea, East China Sea, and South China Sea are 2.00, 3.60, 7.40, and 5.92 Tg C yr^(-1), respectively. The fluxes of organic carbon from the East China Sea and South China Sea to the adjacent oceans are 15.25–36.70 and 43.93 Tg C yr^(-1), respectively. The annual carbon storage of mangroves, wetlands, and seagrass in Chinese coastal waters is 0.36–1.75 Tg C yr^(-1), with a dissolved organic carbon(DOC) output from seagrass beds of up to 0.59 Tg C yr^(-1). Removable organic carbon flux by Chinese macroalgae mariculture account for 0.68 Tg C yr^(-1) and the associated POC depositional and DOC releasing fluxes are 0.14 and 0.82 Tg C yr^(-1), respectively. Thus, in total, the annual output of organic carbon, which is mainly DOC, in the China Seas is 81.72–104.56 Tg C yr^(-1). The DOC efflux from the East China Sea to the adjacent oceans is 15.00–35.00 Tg C yr^(-1). The DOC efflux from the South China Sea is 31.39 Tg C yr^(-1). Although the marginal China Seas seem to be a source of atmospheric CO_2 based on the CO_2 flux at the sea-air interface, the combined effects of the riverine input in the area, oceanic input, depositional export,and microbial carbon pump(DOC conversion and output) indicate that the China Seas represent an important carbon storage area. | Nianzhi JIAO Yantao LIANG Yongyu ZHANG Jihua LIU Yao ZHANG Rui ZHANG Meixun ZHAO Minhan DAI Weidong ZHAI Kunshan GAO Jinming SONG Dongliang YUAN Chao LI Guanghui LIN Xiaoping HUANG Hongqiang YAN Limin HU Zenghu ZHANG Long WANG Chunjie CAO Yawei LUO Tingwei LUO Nannan WANG Hongyue DANG Dongxiao WANG Si ZHANG | 2018 | Science China Earth Sciences2018，61，11： | 12 |
| 9 | Overexpression of miR-30a in lung adenocarcinoma A549 cell line inhibits migration and invasion via targeting EYA2显示文摘MicroRNAs (miRNAs ) 是与癌症的致病有关的小非编码的 RNA 并且仔细的一个班。增加的证据显示 miR-30a 在癌症的发展期间起一个深刻作用。然而,在 non-small-cell 肺癌症(NSCLC ) 的 miR-30a 的功能仍然是模糊的。这里,我们发现 miR-30a 被 qRT-PCR 从 14 个病人在肺腺癌 A549 房间并且在织物样品减少,并且也发现在 A549 房间的 miR-30a 的 overexpression 由愈合创伤的试金禁止了移植和侵略然而并非房间增长和房间周期前进, matrigel 侵略试金,基于山的房间增长试金,和流动 基于cytometry 的房间周期分析分别地。我们进一步在肺腺癌房间行探索了 miR-30a-mediated 基因规定的潜在的机制。EYA2 是 miR-30a 的一个预言的目标,并且 EYA2 表示被 miR-30a 在乳癌房间禁止,这被发现了。我们证明 EYA2 是由在 A549 房间使用双酶的记者试金的 miR-30a 的一个直接目标并且证明 EYA2 蛋白质层次相反地在 A549 和 BEAS-2B 房间与 miR-30a 表示被相关。另外,我们也与表示向量和 miR-30a 模仿的 EYA2 由 cotransfection 在 A549 房间证实了 EYA2 overexpression 的营救效果。一起拿,我们的结果证明在肺腺癌 A549 房间的 miR-30a 的 overexpression 能禁止房间移植和侵略,它部分被归因于 EYA2 的减少表示。我们的调查结果建议 miR-30a 以后可以为肺腺癌的治疗被用作一个新潜在的目标。 | Yuncang Yuan Shangyong Zheng Qian Li Xudong Xiang Tangxin Gao Pengzhan Ran Lijuan Sun Qionglin Huang Fei Xie Jing Du Chunjie Xiao | 2016 | Acta Biochimica et Biophysica Sinica2016，48，3： | 12 |
| 10 | An overview of hydrodynamic studies of mineralization显示文摘液体流动是热水的矿化作用的不可分的部分,并且它的分析和描述组成一个矿化作用模型的重要部分。矿化作用的水动力学学习处理分析驱动力,液体压力政体,液体流动率和方向,并且他们与矿化作用的本地化的关系。这份报纸考察矿化作用的水动力学研究的原则和方法,并且为矿石沉积物研究和矿物质探索讨论他们的意义和限制。流动可能与液体过压,地志的消除,构造变丑,和液体密度有关的液体的驱动力由于加热或咸度变化变化,取决于特定的地质的环境和矿化作用过程。学习方法可以被分类进三种类型,放大了(领域) 观察,显微镜的分析,并且数字建模。放大了的特征陈述语气显著地 overpressured (特别 lithostatic 或 supralithostatic ) 液体系统包括水平静脉,沙注射堤,和水力的角砾岩。显微镜的研究,特别液体包括的 microthermometry 和液体包括飞机(联邦信息处理标准) 的 microthermometry 能关于液体温度,压力,和液体结构的关系提供重要信息,因此抑制液体流动模型。数字建模能被执行解决管理液体流动,热转移,岩石变丑和化学反应的部分微分方程,以便模仿液体的分发在 2D 或 3D 空间并且整个时间的压力,温度,液体流动率和方向,和矿物质降水或溶解。矿化作用的水动力学研究的结果能提高我们热水的沉积物的形成过程的理解,并且能在矿物质探索直接或间接地被使用。 | Guoxiang Chi Chunji Xue | 2011 | Geoscience Frontiers2011，2，3： | 11 |
| 11 | Construction of an integrated map and location of a bruchid resistance gene in mung bean显示文摘Bruchid beetle(Callosobruchus chinensis) poses a serious threat to the production and storage of mung bean(Vigna radiata). Mapping bruchid resistance(Br) will provide an important basis for cloning the responsible gene(s) and elucidating its functional mechanism, and will also facilitate marker-assisted selection in mung bean breeding. Here, we report the construction of the genetic linkage groups of mung bean and mapping of the Br1 locus using an RIL population derived from a cross between Berken, a bruchid-susceptible line, and ACC41, a bruchid-resistant line. A total of 560 markers were mapped onto 11 linkage groups,with 38.0% of the markers showing distorted segregation. The lengths of the linkage groups ranged from 45.2 to 117.0 c M with a total coverage of 732.9 c M and an average interval of1.3 c M between loci. Br1 was located on LG9 between BM202(0.7 c M) and Vr2-627(1.7 c M).Based on 270 shared SSR markers, most of the linkage groups were assigned to specific chromosomes. These results should further accelerate the genetic study of this crop. | Lixia Wang Chuanshu Wu Min Zhong Dan Zhao Li Mei Honglin Chen Suhua Wang Chunji Liu Xuzhen Cheng | 2016 | The Crop Journal2016，4，5： | 9 |
| 12 | Provable Efficient Certificateless Group Key Exchange Protocol显示文摘Certificateless public key cryptography (CL-PKC) avoids the inherent escrow of identity-based cryptography and does not require certificates to guarantee the authenticity of public keys. Based on CL-PKC, we present an efficient constant-round group key exchange protocol, which is provably secure under the intractability of computation Diffie-Hellman problem. Our proto- col is a contributory key exchange with perfect forward secrecy and has only two communication rounds. So it is more efficient than other protocols. Moreover, our protocol provides a method to design efficient constant-round group key exchange protocols and most secret sharing schemes could be adopted to construct our protocol. | CAO Chunjie MA Jianfeng MOON Sangjae | 2007 | Wuhan University Journal of Natural Sciences2007，12，1： | 8 |
| 13 | WARFARE COMMAND STRATAGEM ANALYSIS FOR WINNING BASED ON LANCHESTER ATTRITION MODELS显示文摘Lanchester 方程和他们的延期广泛地被用来在战争模型计算摩擦。当攻击方面的全部的战斗能力不比保卫方面的优异时,当前的纸为赢处理战争命令决策问题。为这个问题,相应战争命令计策,能转变战场状况,被考虑战争信息因素的影响求婚并且分析份量上。在军事冲突的申请例子证明建议模型和战争的可行性和有效性为赢命令计策。研究结果可以为战争命令决策提供一本理论参考书。 | Xiangyong CHEN Yuanwei JING Chunji LI Mingwei LI | 2012 | Journal of Systems Science and Systems Engineering2012，21，1： | 8 |
| 14 | Dermal fibroblast expression of stromal cellderived factor-1 (SDF-1) promotes epidermal keratinocyte proliferation in normal and diseased skin显示文摘Stromal 房间为 overlying 上皮提供关键微型环境。这里,我们调查了 stromal 的表示和功能房间特定的蛋白质, stromal 导出房间的 factor-1 (SDF-1 ) ,在正常人的皮肤并且在 diseased 的纸巾皮肤。Immunohistology 和激光俘获 microdissection (最小公倍数) 联合了揭示的量的即时 RT-PCR 那 SDF-1 组成地并且主要在 vivo 在正常人的皮肤在真皮的 stromal 房间被表示。使我们吃惊的是,一极其, SDF-1 抄写的高水平在 vivo 在正常人的皮肤的真皮被观察,比打字由许多更高的 mRNA 表示水平证实了我骨胶原,在人的皮肤的最丰富、高度表示的蛋白质。SDF-1 也是在包括干癣,基础房间癌(电子消息传输方式) ,和有鳞的房间癌(SCC ) 的许多人的皮混乱的纸巾的 upregulated。为 SDF-1 和 HSP47 (热吃惊蛋白质 47 ) 的两倍 immunostaining,成纤维细胞的一个标记,表明成纤维细胞是在正常和 diseased 皮肤的 stroma-cell-derived SDF-1 的主要来源。机能上地, SDF-1 激活 ERK (extracellular-signal-regulated kinases ) 是的小径和功能刺激表皮的 keratinocyte 增长的 mitogen。在有到皮肤等价物文化的 rhSDF-1 的真皮的成纤维细胞和处理的 SDF-1 的两 overexpression 显著地增加了 keratinocyte 层和表皮的厚度的数字。相反地, keratinocyte 增长上的 SDF-1 的刺激功能被防碍 CXCR4 将近完全消除, SDF-1 的特定的受体,或由在成纤维细胞的 SDF-1 击倒。我们的数据揭示那 SDF-1 极其高级处于生理、病理学的皮肤条件为表皮的 keratinocyte 增长提供关键微型环境。 | Chunji Quan Moon Kvun Cho Yuan Shao Laurel E. Mianecki Eric Liao Daniel Perry Taihao Quan | 2015 | Protein & Cell2015，6，12： | 8 |
| 15 | Gene admixture in ethnic populations in upper part of Silk Road revealed by mtDNA polymorphism显示文摘To evaluate the gene admixture on the current genetic landscape in Gansu Corridor (GC) in China, the upper part of the ancient Silk Road which connects the Eastern and Central Asia, we examined mitochondrial DNA (mtDNA) polymorphisms of five ethnic populations in this study. Using PCR-RFLP and sequencing, we analyzed mtDNA haplotypes in 242 unrelated samples in three ethnic populations from the GC region and two ethnic populations from the adjacent Xinjiang Uygur Autonomous Region of China. We analyzed the data in comparison with the previously reported data from Eastern, Central and Western Asia and Europe. We found that both European-specific haplogroups and Eastern Asian-specific haplogroups exist in the Gansu Corridor populations, while a modest matrilineal gene flow from Europeans to this region was revealed. The Gansu Corridor populations are genetically located between Eastern Asians and Central Asians, both of who contributed significantly to the maternal lineages of the GC populations. This study made the landscape of the gene flow and admixture along the Silk Road from Europe, through Central Asia, to the upper part of the Silk Road more complete. | YANG LiuQi, TAN SiJie, YU HaiJing, ZHENG BingRong, QIAO EnFa, DONG YongLi, ZAN RuiGuang & XIAO ChunJie Key Laboratory of Bioresources Conservation and Utilization & Human Genetics Center, Yunnan University, Kunming 650091, China | 2008 | Science China(Life Sciences)2008，51，5： | 7 |
| 16 | Association of WNK1 exon 1 polymorphisms with essential hypertension in Hani and Yi minorities of China显示文摘在有在少数的必要高血压的 1 WNK1 基因中国的 Hani 和 Yi 组织的 exon 的多型性的协会在盒子控制学习被调查。包含 WNK1 基因 exon 的 1257 bp 的顺序 1 在 1307 个个人(649 个必要高血压题目和 658 控制) 被决定在 Hani 和 Yi 少数组识别 SNP。十一以前已知的 SNP (rs3168640, rs11885, rs11554421 和 rs34880640 ) 中的四个被识别。SNP 分析显示 SNP rs11885 和 rs11554421 显著地在 Hani 和 Yi 人口与高血压被联系,并且 rs34880640 显著地在 Hani 然而并非在 Yi 人口与高血压被联系,为 covariates 调整了。Haplotype 分析显示 haplotype H1 显著地减少了在两张人口的高血压的风险。这些结果建议 WNK1 多型性在 Hani 和 Yi 人口涉及必要高血压的倾向,它的效果显示出清楚的人口特性。这发现在决定基因因素把疾病治疗与疾病并且这样联系了支持了人口特性的重要性。 | Yina Cun Jin Li Wenru Tang Xiaozhi Sheng Haijing Yu Bingrong Zheng Chunjie Xiao | 2011 | Journal of Genetics and Genomics2011，38，4： | 7 |
| 17 | Hydrodynamic regime as a major control on localization of uranium mineralization in sedimentary basins显示文摘Uranium deposits in sedimentary basins can be formed at various depths,from near surface to the basement.While many factors may have played a role in controlling the location of mineralization,examination of various examples in the world,coupled with numerical modeling of fluid flow,indicates that the hydrodynamic regime of a basin may have exerted a major control on the localization of uranium deposits.If a basin is strongly overpressured,due to rapid sedimentation,abundance of low-permeability sediments or generation of hydrocarbons,fluid flow is dominantly upward and uranium mineralization is likely limited at shallow depths.If a basin is moderately overpressured,upward moving fluids carrying reducing agents may meet downward moving,oxidizing,uranium-bearing fluids in the middle of the basin,forming uranium deposits at moderate depths.If a basin is weakly or not overpressured,either due to slow sedimentation or dominance of high-permeability lithologies,minor topographic disturbance or density variation may drive oxidizing fluids to the bottom of the basin,leaching uranium either from the basin or the basement,forming unconformity-type uranium deposits.It is therefore important to analyze the hydrodynamic regime of a basin in order to predict the most likely type and location of uranium deposits in the basin. | CHI GuoXiang XUE ChunJi | 2014 | Science China Earth Sciences2014，57，12： | 6 |
| 18 | Distribution of isotopes and chemicals in precipitation in Shule River Basin,northwestern China:an implication for water cycle and groundwater recharge显示文摘The distribution of stable isotopes and ions in precipitation in the Shule River Basin,northwestern China,were investigated to understand the regional water cycle and precipitation input to groundwater recharge.The study found that the mean annual concentrations of Ca2+,Na+,SO42–,Cl–,Mg2+,NO3–,and K+ in the basin were lower than those in other arid areas of northwestern China.The average concentrations of ions in the lower reaches of the Shule River were higher than those in the upper reaches.The results showed that the main ionic concentrations decreased with the increase of precipitation amount,indicating that heavy precipitation cannot only wash crustal aerosols out of the atmosphere,but also create a dilution effect.Cl– and Na+ in precipitation had a strong and positive correlation,suggesting a common origin for the two ions.However,the excess of Na+,combined with non-marine SO42– and NO3–,indicated that some ions were contributed by terrestrial origins.In the extremely arid regions of northwestern China,the evaporation process obviously changes the original relationship between δ2H and δ18O in precipitation,and leads to dexcess values <8‰.δ18O and temperature were significantly correlated,suggested that temperature strongly affected the characteristics of isotopes in the study area.The δ18O value indicates a dominant effect of westerly air masses and southwest monsoon in warm months,and the integrated influence of westerly and Siberian-Mongolian polar air masses in cold months.The d-excess values were generally lower in warm months than those in cold months,indicating that post-condensation processes played a significant role in the water cycle.The results provide reliable precipitation input information that can be used in future groundwater recharge calculations in the study area. | ZHAO Wei MA Jinzhu GU Chunjie QI Shi ZHU Gaofeng HE Jiahua | 2016 | Journal of Arid Land2016，8，6： | 6 |
| 19 | A new sorbent that simultaneously sequesters multiple classes ofpollutants from water: Surfactant modified zeolite显示文摘A zeolite (ZFA) was synthesized from coal fly ash and then modified using hexadecyltrimethylammonium. The surfactant modified ZFA (SMZFA) was evaluated for its versatility to sequester multiple classes of pollutants from water. The target pollutants include ionic inorganic pollutants (ammonium and phosphate), ionic organic pollutants (methylene blue and humic acid), ionizable organic pollutants (bisphenol A,-chlorophenol and phenol, with different pKa), and electrically neutral or-ganic pollutants (aniline, nitrobenzene, and naphthalene, with different hydrophobicity). The SMZFA showed high potential for the retention of ammonium and phosphate, being comparable with ZFA. While the negative charge in the internal pores of zeolite was responsible for the retention of ammonium, the oxides of CaO, Al2O3and Fe2O3in the non-zeolite fraction, which originated from coal fly ash but received modification during zeolite synthesis, accounted for the removal of phosphate. Results also showed that while ZFA had little affinity for humic acid, the ionizable, and the electrically neutral organic compounds, SMZFA exhibited greatly enhanced adsorption capacity. Thus, the surfactant modified external surface, which formed a bilayer micelle of zeolite, imparts a hydrophobic characteristic that enables the uptake of the organic pollutants. We showed that SMZFA is a promising versatile sorbent for water treatment. | XIE Qiang XIE Jie CHI LiNa LI ChunJie WU DeYi ZHANG ZhenJia KONG HaiNan | 2013 | Science China(Technological Sciences)2013，56，7： | 5 |
| 20 | Hydrodynamic analysis of clastic injection and hydraulic fracturing structures in the Jinding Zn-Pb deposit,Yunnan,China显示文摘Jinding Zn-Pb 存款通常被考虑了以一个相对被动的方法从传播 basinal 液体形成了,与液体流动被结构和沉积外形正在控制,类似于许多另外的招待沉积的底金属存款。然而,几最近的研究在 Jinding 存款的开的坑揭示了沙注射结构,恼人的角砾岩,和水力的破裂的存在并且建议存款从 overpressured 液体的爆炸版本被形成。这研究报导液体的新观察过压相关从地下的活动方式(Paomaping 和 Fengzishan ) 组织,它比在开的坑显示出更清楚的横切的关系。观察结构包括:1 ) 沙(楳湧晩捩湡汴 ? 潣瑮楲畢整琠? 桴 ? 潴慴? 票牤 ' 夷典? | Guoxiang Chi Chunji Xue Hairuo Qing Wei Xue Jiangwei Zhang Yunqiang Sun | 2012 | Geoscience Frontiers2012，3，1： | 5 |
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