|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | In vitro cytocompatibility evaluation of poly(octamethylene citrate) monomers toward their use in orthopedic regenerative engineering显示文摘Citrate based polymer poly(octamethylene citrate)(POC)has shown promise when formulated into composite material containing up to 65 wt%hydroxylapatite(HA)for orthopedic applications.Despite significant research into POC,insufficient information about the biocompatibility of the monomers 1,8-Octanediol and Citrate used in its synthesis is available.Herein,we investigated the acute cytotoxicity,immune response,and long-term functionality of both monomers.Our results showed a cell-type dependent cytotoxicity of the two monomers:1,8-Octanediol induced less acute toxicity to 3T3 fibroblasts than Citrate while presenting comparable cytotoxicity to MG63 osteoblast-like cells;however,Citrate demonstrated enhanced compatibility with hMSCs compared to 1,8-Octanediol.The critical cytotoxic concentration values EC30 and EC50,standard for comparing cytotoxicity of chemicals,were also provided.Additionally,Citrate showed slower and less inhibitory effects on long-term hMSC cell proliferation compared with 1,8-Octanediol.Furthermore,osteogenic differentiation of hMSCs exposure to Citrate resulted in less inhibitory effect on alkaline phosphatase(ALP)production.Neither monomer triggered undesired pro-inflammatory responses.In combination with diffusion model analysis of monomer release from cylindrical implants,based on which the maximum concentration of monomers in contact with bone tissue was estimated to be 2.2104 mmol/L,far lower than the critical cytotoxic concentrations as well as the 1,8-Octanediol concentration(0.4 mg/mL or 2.7 mmol/L)affecting hMSCs differentiation,we provide strong evidence for the cytocompatibility of the two monomers degraded from citrate-based composites in the orthopedic setting. | Chuying Ma Ethan Gerhard Qiaoling Lin Silun Xia April Dawn Armstrong Jian Yang | 2018 | Bioactive Materials2018，3，1： | 2 |
| 2 | Relationship of age and flex to health-related quality of life in patients with heart failure显示文摘 | Chui MA Eckert GJ | 2004 | Am JCrit Care2004，13，2： | 1 |
| 3 | Relationship of age and sex to health related quality of life in patients with heart failure显示文摘 | Hou N Chui MA Eckert GJ | 2004 | Am J Crit Care2004，13，2： | 1 |
| 4 | ToU receptor 4 expression and significance in acute necrotic pancreatitis 显示文摘 | MA JM CHUI J YANG ZJ | 2007 | Journal of Central South University (Science and Technology)2007，26，6： | 1 |
| 5 | Recent developments in therapeutic cancer vaccines显示文摘 | Morse MA Chui S Hobeika A | 2005 | Nat Clin Pract Oncol2005，2，2： | 1 |
| 6 | Relationship of age and sex to health related quality of life in patients with heart failure显示文摘 | Hou N Chui MA Eckert GJ | 2004 | Am J Crit Care2004，13，2： | 1 |
| 7 | PPARgamma regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1显示文摘 | Chui PC Guan HP Lehrke M Lazar MA | 2005 | J Clin Invest2005，115，8： | 1 |
| 8 | Identifying prediabetes using fasting insulin levels显示文摘 | Johnson JL Duick DS Chui MA | 2010 | Endocr Pract2010，16，1： | 1 |
| 9 | Exploring the impact of an automated prescription-filling device on community pharmacy techni- cian worktlow显示文摘 | Walsh KE Chui MA Kieser MA | 2011 | J Am Pharm Assoc2011，51，5： | 1 |
| 10 | Modeling of oxy-fuel com- bustion for a western Canadian sub-bituminous coal显示文摘 | CHUI EH DOUGLAS MA TAN Y W | 2003 | Fuel2003，82，10： | 1 |
| 11 | Vaccines and gene therapy for colorectal cancer显示文摘 | Chui SY Morse MA | | 0，，： | 1 |
| 12 | Relationship of age and sex to healthrelated quality of life in patients with heart failure显示文摘 | Hou N Chui MA Eckert GJ | 2004 | Am J Crit Care2004，13，2： | 1 |
| 13 | A qualitati-e assessment of a com- munity pharmacy cogniti-e pharmaceutical ser-ices program, using a work system approach 显示文摘 | Chui MA Mott DA Maxwell L | 2012 | Research in Social and Administrati-e Pharmacy2012，8，3： | 1 |
| 14 | Facilitating col- laboration between pharmacists and physicians using an it- erative interview process显示文摘 | Chui MA Stone JA Odukoya OK | 2014 | J Am Pharm Assoc2014，54，1： | 1 |
| 15 | Development of a scale to measure pharmacists' self-efficacy in performing medication therapy management services显示文摘 | Martin BA Chui MA Thorpe JM | 2010 | Res Social Adm Pharrn2010，6，2： | 1 |
| 16 | Immunoglobulin mimicry by Hepatitis C Virus envelope protein E2显示文摘 | Yu-Wen Hu Lynda Rocheleau Bryce Larke Linda Chui Bonita Lee Mang Ma Song Liu Teye Omlin Martin Pelchat Earl G. Brown | 2004 | Virology2004，，2： | 1 |
| 17 | A qualitative assessment of a community pharmacy cognitive pharmaceutical services program,using a work system approach显示文摘 | Chui MA Mott DA Maxwell L | | 0，，03： | 1 |
| 18 | Regulatory and effector T cell subsets and dendritic cells in breast cancer显示文摘 | Morse MA Doldo T | 2004 | J Clin Onco2004，22，14： | 1 |
| 19 | Modeling of oxy-fuel combustion for a western Canadian sub-bituminous coal 显示文摘 | CHUI EH DOUGLAS MA TAN Y | 2003 | Fuel2003，82，10： | 1 |
| 20 | A specific cell - penetrat- ing peptide induces apoptosis in SKOV3 ceils by down - regulation of Bcl - 2 显示文摘 | Ma Chuying Yin Guangfu You Fei | 2013 | Biotechnol Lett2013，35，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员