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| 1 | Oroclinal bending and block rotations in South China since the Mesozoic——Geological and paleomagnetic evidence显示文摘THE South China Block exhibits a complex structural pattern in its Neoproterozoic-Mesozoic sedimentary cover. The lack of knowledge about the formation of this pattern hinders our understanding of the regional tectonic evolution and paleogeography, and the reconstruction of Phanerozoic apparent polar wander path(s). In this note we present a synthesis based on a paleomagnetic and tectonic analysis, which suggests that (i) the structural pattern over | LI Zhengxiang, FANG Dajun, Christopher McA. Powell and LOU Gang1. Department of Geology and Geophysics, The University of Western Australia, Nedlands WA 6907, Australia 2. Department of Earth Sciences, Zhejiang University, Hangzhou 310027, China | 1997 | Chinese Science Bulletin1997，42，2： | 7 |
| 2 | Protein kinase C-θ:signaling from the center of the T cell synapse显示文摘 | Christopher WA Bjorn A Timothy JS | 2002 | Current Opinion in Immunology2002，14，2： | 1 |
| 3 | Residual Embryonic Cells as Precursors of a Barrett’s-like Metaplasia显示文摘 | Xia Wang Hong Ouyang Yusuke Yamamoto Pooja Ashok Kumar Tay Seok Wei Rania Dagher Matthew Vincent Xin Lu Andrew M. Bellizzi Khek Yu Ho Christopher P. Crum Wa Xian Frank McKeon | 2011 | Cell2011，，7： | 1 |
| 4 | A novel blueprint for ‘top down’ differentiation defines the cervical squamocolumnar junction during development, reproductive life, and neoplasia显示文摘 | Michael Herfs Sara O Vargas Yusuke Yamamoto Brooke E Howitt Marisa R Nucci Jason L Hornick Frank D Mckeon Wa Xian Christopher P Crum | 2013 | J. Pathol2013，，3： | 1 |
| 5 | Establishment of head and neck squamous cell carcinoma mouse models for cetuximab resistance and sensitivity显示文摘Aim:Acquired resistance to the targeted agent cetuximab poses a significant challenge in finding effective anti-cancer treatments for head and neck squamous cell carcinoma(HNSCC).To accurately study novel combination treatments,suitable preclinical mouse models for cetuximab resistance are key yet currently limited.This study aimed to optimize an acquired cetuximab-resistant mouse model,with preservation of the innate immunity,ensuring intact antibody-dependent cellular cytotoxicity(ADCC)functionality.Methods:Cetuximab-sensitive and acquired-resistant HNSCC cell lines,generated in vitro,were subcutaneously engrafted in Rag2 knock-out(KO),BALB/c Nude and CB17 Scid mice with/without Matrigel or Geltrex.Once tumor growth was established,mice were intraperitoneally injected twice a week with cetuximab for a maximum of 3 weeks.In addition,immunohistochemistry was used to evaluate the tumor and its microenvironment.Results:Despite several adjustments in cell number,cell lines and the addition of Matrigel,Rag2 KO and BALB/C Nude mice proved to be unsuitable for xenografting our HNSCC cell lines.Durable tumor growth of resistant SC263-R cells could be induced in CB17 Scid mice.However,these cells had lost their resistance phenotype in vivo.Immunohistochemistry revealed a high infiltration of macrophages in cetuximab-treated SC263-R tumors.FaDu-S and FaDu-R cells successfully engrafted into CB17 Scid mice and maintained their sensitivity/resistance to cetuximab.Conclusion:We have established in vivo HNSCC mouse models with intact ADCC functionality for cetuximab resistance and sensitivity using the FaDu-R and FaDu-S cell lines,respectively.These models serve as valuable tools for investigating cetuximab resistance mechanisms and exploring novel drug combination strategies. | Hannah Zaryouh Ines De Pauw Hasan Baysal Joran Melis Valentin Van den Bossche Christophe Hermans Ho Wa Lau Hide Lambrechts Celine Merlin Cyril Corbet Marc Peeters Jan Baptist Vermorken Jorrit De Waele Filip Lardon An Wouters | 2023 | Cancer Drug Resistance2023，6，4： | 0 |
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