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您的检索式：作者名="Christophe Hitte"
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| 1 | Dog10K: an international sequencing effort to advance studies of canine domestication, phenotypes and health显示文摘Dogs are the most phenotypically diverse mammalian species, and they possess more known heritable disorders than any other non-human mammal. Efforts to catalog and characterize genetic variation across well-chosen populations of canines are necessary to advance our understanding of their evolutionary history and genetic architecture. To date, no organized effort has been undertaken to sequence the world’s canid populations. The Dog10 K Consortium(http://gffzz8e6b994fb05d4249h0nffwx6u9ufc66p5.ffgz.tsg.suse.edu.cn kgenomes.org) is an international collaboration of researchers from across the globe who will generate 20× whole genomes from 10 000 canids in 5 years.This effort will capture the genetic diversity that underlies the phenotypic and geographical variability of modern canids worldwide. Breeds, village dogs, niche populations and extended pedigrees are currently being sequenced, and de novo assemblies of multiple canids are being constructed. This unprecedented dataset will address the genetic underpinnings of domestication, breed formation, aging, behavior and morphological variation. More generally, this effort will advance our understanding of human and canine health. | Elaine A.Ostrander Guo-Dong Wang Greger Larson Bridgett M.vonHoldt Brian W.Davis Vidhya Jagannathan Christophe Hitte Robert K.Wayne Ya-Ping Zhang the Dog10K Consortium | 2019 | National Science Review2019，6，4： | 3 |
| 2 | Development and Characterization of a Scalable Controlled Precipitation Process to Enhance the Dissolution of Poorly Water-Soluble Drugs显示文摘 | True L. Rogers Ian B. Gillespie James E. Hitt Kevin L. Fransen Cindy A. Crowl Christopher J. Tucker Gary B. Kupperblatt Joe N. Becker Deb L. Wilson Clifford Todd Charles F. Broomall Jonathan C. Evans Edmund J. Elder | 2004 | Pharmaceutical Research2004，，11： | 1 |
| 3 | Toward the identi?cation and role of structural variations during dog domestication显示文摘To date, we know little about the genetic diversity and development mechanisms that, through the process of domestication, have made the modern dog emerge. Following the processes of domestication and a phase of intense artificial selection,dogs became our auxiliaries for hunting, guarding and finally our best friends. The range of phenotypic diversity in dogs today greatly exceeds that of its ancestors, the wolves, making dogs the most morphologically diverse species of terrestrial mammals(1)To advance these domestication research questions, studies are now focusing on differences in the content, organization and structure of the genome, called structural variations (SV),as a major source of genetic and phenotypic diversity. | Christophe Hitte | 2019 | National Science Review2019，6，1： | 0 |
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