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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | Mechanical properties of oxidation resistant Ni-Cr foams 显示文摘 | CHOE H DUNAND D C | 2004 | Materials Science and Engineering A2004，384，12： | 1 |
| 3 | The Economic Benefits of Surface Water Quality Improvements in Development Countries:a Case Study of Davao Philippine显示文摘 | Choe K Whittington D | | 0，，72： | 1 |
| 4 | Cathodoluminescence Study of Novel Sol-gel Derived Y3-xAl5O12:Tbx Phosphors显示文摘 | Choe J Y Ravichandran D Blomquist S M | 2001 | Journal of Luminescence2001，93，： | 1 |
| 5 | Association of visceral obesity and early colorectal neoplasia显示文摘 | Choe EK Kim D Kim HJ | 2013 | World J Gastmenterol2013，19，45： | 1 |
| 6 | The multifunctional fish gill:dominant site of gas exchange,osmoregulation,acid-base regulation,and excretion of nitrogenous waste显示文摘 | EVANS D H PIERMARINI P M CHOE K P | 2005 | Physicalogical Reviews2005，85，： | 1 |
| 7 | Sediment-water exchange of total mercury and monomethyl in the San Francisco Bay-Delta显示文摘 | Choe K Y Gill G A Lehman R D | 2004 | Limnology and Oceanography2004，49，： | 1 |
| 8 | The multifunctional fish gill : dominant site of gas exchange, osmoregulation, acid-base regulation, and excretion of nitrogenous waste 显示文摘 | Evans D H Pierrnarini P M Choe K P | 2005 | Physiol Rev2005，85，1： | 1 |
| 9 | The multifunctional fish gill: Dominant site of gas exchange, osmoregulation, acid-base regulation, and excretion of nitrogenous waste显示文摘 | Evans D H Piermarini P M Choe K P | 2005 | Physiol Rev2005，85，1： | 1 |
| 10 | 显示文摘 | Choe H Dunand D C | 2004 | Materials Science and Engineering A2004，384，12： | 1 |
| 11 | C T findings in primary thymic carcinoma显示文摘 | Lee J D Choe K O Kim S J | 1991 | J Comput Assist Tomogr1991，15，3： | 1 |
| 12 | The Arabidopsis dwarf1 mutant is defective in the conversion of 24-methylenecholesterol to eampesterol in brassinosteroid biosynthesis显示文摘 | Choe S Dilkes B P Gregory B D | 1999 | Plant Physiology1999，119，3： | 1 |
| 13 | The muhifuncfional fish gill: dominant site of gas exchange, osmoregulation, acid-base regulation, and excretion of nitrogenous waste 显示文摘 | EVANS D H PIERMARINI P M CHOE K P | 2005 | Physiological Reviews2005，85，1： | 1 |
| 14 | Analysis of the complete genome sequence and capsid region of black queen cell viruses from infected honeybees (Apis me llifera) in Korea显示文摘 | REDDY KE NOH JH CHOE SE KWEON CH YOO MS DOAN HT RAMYA M YOON BS NGUYEN LT NGUYEN TT VAN QUYEN D JUNG SC CHANG KY KANG SW | 2013 | Virus Genes2013，47，1： | 1 |
| 15 | Expanding the degree of freedom of observation on depth-direction by the triple-separated slant- ed parallax barrier in autostereoscopic 3-D display显示文摘 | LEE K H CHOE Y S LEE D K | 2013 | Proccedings of the SPIE2013，8738，87： | 1 |
| 16 | The multifunctional fish gill: dominant site of gas exchange, osmoregulation, acid-base regulation, and excretion of nitrogenous waste 显示文摘 | EVANS D H PIERMARINI P M CHOE K P | 2005 | Physiology Reviews2005，85，1： | 1 |
| 17 | Impaired synaptic vesicle release and immaturity of neuromuscular junc- tions in spinal muscular atrophy mice 显示文摘 | Kong L Wang X Choe D W | 2009 | J Neurosci2009，29，3： | 1 |
| 18 | As- caroside signaling is widely conserved among nema- todes显示文摘 | CHOE A VON REUSS S H KOGAN D | 2012 | Curr Bio12012，22，9： | 1 |
| 19 | Polyacrylonitrile electrolyte-based Li ion batteries显示文摘 | Abraham K M Choe H S Pasquariello D M | 1998 | Electrochim Acta1998，43，： | 1 |
| 20 | The multifunctional fish gill: Dominant site of gas exchange, osmoregulation, acid-base regulation, and excretion of nitrogenous waste 显示文摘 | Evans D H Piermarini P M Choe K P | 2005 | Physiological Reviews2005，85，1： | 1 |
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