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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | Sonochemical synthesis of amorphous iron显示文摘 | SUSLICK K S CHOE S B CICHOWLAS A A | 1991 | Nature1991，353，： | 1 |
| 3 | Sediment-water exchange of total mercury and monomethyl in the San Francisco Bay-Delta显示文摘 | Choe K Y Gill G A Lehman R D | 2004 | Limnology and Oceanography2004，49，： | 1 |
| 4 | Oxidative and color stability of cooked ground pork containing lotus leaf(Nelumbo nucifera) and barley leaf (Hordeum vulgare) powder during refrigerated storage显示文摘 | CHOE J H JANG A LEE E S | 2011 | Meat Science2011，87，1： | 1 |
| 5 | Delayed ICU admis-sion with community- acquired severe sepsis greatly increas- es mortality and resource use 显示文摘 | A Shorr Y Choe W Linde- Zwirble | 2011 | Critical Care2011，15，1： | 1 |
| 6 | Apolipoprotein E and other eerebrospinal fluid proteins differentiate ante mortem variant Creutzfeldt-Jakob disease from ante mortem sporadic Creutzfeldt - Jakob disease 显示文摘 | Choe LH Green A Knight RS | 2002 | Electrophoresis2002，23，14： | 1 |
| 7 | Sex-specific mating pheromones in the nematode Panagrellus redivivus显示文摘 | CHOE A CHUMAN T VON REUSS S H | 2012 | Proc Natl Acad Sci U S A2012，109，20： | 1 |
| 8 | Antioxidant activities of lotusleaves (nelumbo nucifera) and barley leaves (hordeumvulgare) extracts 显示文摘 | Choe J Jang A Choi J | 2010 | Food Science and Biotechnology2010，19，3： | 1 |
| 9 | As- caroside signaling is widely conserved among nema- todes显示文摘 | CHOE A VON REUSS S H KOGAN D | 2012 | Curr Bio12012，22，9： | 1 |
| 10 | Thromboeytosis after major lower extremity trauma:mechanism and possible role in free flap failure显示文摘 | Choe E I Kasabian A K Ko lker A R | 1996 | Ann Plast Surg1996，36，5： | 1 |
| 11 | Functional expression of the seven-transmembrane HIV-1 co-receptor APJ in neural cells 显示文摘 | Choe W Albright A Sulcove J | 2000 | J Neurovirol2000，6，1： | 1 |
| 12 | Oxidative and color stability of cooked ground pork containing lotus leaf (Nelumbo nucifera ) and barley leaf ( Hordettm vulgare ) powder during refrigerated storage显示文摘 | Choe J H Jang A Lee E S | 2011 | Meat Science2011，87，1： | 1 |
| 13 | Isolation of colloidal monomethyl mercury in natural waters using cross-flow ultrafiltration techniques 显示文摘 | CHOE Key-young GARY A G | 2001 | Marine Chemistry2001，76，： | 1 |
| 14 | Uptake and biotransformation of trichloroethylene byhybrid poplars显示文摘 | Newman L A Strand S E Choe N | 1997 | Environmental Science Technology1997，31，： | 1 |
| 15 | Uptake and biotranslorma- tion of triehloroethylene by hybrid poplars 显示文摘 | Newman L A Strand S E Choe N | 1997 | Environmental Science & Technology1997，31，4： | 1 |
| 16 | Financial system and economic growth: the korean experience显示文摘 | Choe C Moosa I A | 1999 | World Development1999，27，6： | 1 |
| 17 | C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon 显示文摘 | Choe CU Schulze-Bahr E Neu A | 2006 | Hum Mol Cenet2006，15，19： | 1 |
| 18 | Tumor cavitation in stage I nonsmall cell lung cancer: epidermal growth factor receptor expression and prediction of poor outcome 显示文摘 | Onn A Choe DH Herbst RS | 2005 | Radiology2005，237，1： | 1 |
| 19 | C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon显示文摘 | Choe CU Schulze-Bahr E Neu A | 2006 | Hum Mol Genet2006，15，19： | 1 |
| 20 | The Korean American women's face:anthropometric measurements and quan titative analysis of facial aesthetics显示文摘 | CHOE K S SCLAFANI A P LITNER J A | 2004 | Arch Facial Plast Surg2004，6，4： | 1 |
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