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| 1 | System Design and Analysis of Hydrocarbon Scramjet with Regeneration Cooling and Expansion Cycle显示文摘A new expansion cycle scheme of the scramjet engine system including a hydrocarbon-fuel-based(kerosene)regenerative cooling system and supercritical/cracking kerosene-based turbo-pump was proposed in this paper.In this cycle scbeme,the supercritical/cracking kerosene with high pressure and high temperature is formed through the cooling channel.And then,in order to make better use of the high energy of the supercritical/cracking fuel,the supercritical/cracking kerosene fuel was used to drive the turbo-pump to obtain a high pressure of the cold kerosene fuel at the entrance of the cooling channel.In the end,the supercritical/cracking kerosene from the turbine exit is injected into the scramjet combustor.Such supercritical/cracking kerosene fuel can decrease the fuel-air mixing length and increase the combustion efficiency,due to the gas state and low molecular weight of the cracking fuel.In order to ignite the cold kerosene in the start-up stage,the ethylene-assisted ignition subsystem was applied.In the present paper,operating modes and characteristics of the expansion cycle system are first described.And then,the overall design of the system and the characterisitics of the start-up process are analyzed numerically to investigate effects of the system parameters on the scramjet start-up performance.The results show that the expansion cycle system proposed in this paper can work well under typical conditions.The research work in this paper can help to make a solid foundation for the research on the coupling characteristics between the dynamics and thermodynamics of the scramjet expansion cycle system. | WU Xianyu YANG Jun ZHANG Hua SHEN Chibing | 2015 | Journal of Thermal Science2015，24，4： | 6 |
| 2 | Neutralization of interleukin-17A alleviates burn-induced intestinal barrier disruption via reducing pro-inflammatory cytokines in a mouse model显示文摘Background:The intestinal barrier integrity can be disrupted due to burn injury,which is responsible for local and systemic inflammatory responses.Anti-inflammation strategy is one of the proposed therapeutic approaches to control inflammatory cascade at an early stage.Interleukin-17A(IL-17A)plays a critical role in inflammatory diseases.However,the role of IL-17A in the progression of burn-induced intestinal inflammation is poorly understood.In this study,we aimed to investigate the effect of IL-17A and associated pro-inflammatory cytokines that were deeply involved in the pathogenesis of burn-induced intestinal inflammatory injury,and furthermore,we sought to determine the early source of IL-17A in the intestine.Methods:Mouse burn model was successfully established with infliction of 30%total body surface area scald burn.The histopathological manifestation,intestinal permeability,zonula occludens-1 expression,pro-inflammatory cytokines were determined with or without IL-17A-neutralization.Flow cytometry was used to detect the major source of IL-17A^(+)cells in the intestine.Results:Burn caused intestinal barrier damage,increase of intestinal permeability,alteration of zonula occludens-1 expressions,elevation of IL-17A,IL-6,IL-1βand tumor necrosis factor-α(TNF-α),whereas IL-17A neutralization dramatically alleviated burn-induced intestinal barrier disruption,maintained zonula occludens-1 expression,and noticeably,inhibited pro-inflammatory cytokines elevation.In addition,we observed that the proportion of intestinal IL-17A^(+)Vγ4^(+)T subtype cells(but not IL-17A^(+)Vγ1^(+)T subtype cells)were increased in burn group,and neutralization of IL-17A suppressed this increase.Conclusions:The main original findings of this study are intestinal mucosa barrier is disrupted after burn through affecting the expression of pro-inflammatory cytokines,and a protective role of IL-17A neutralization for intestinal mucosa barrier is determined.Furthermore,Vγ4^(+)T cells are identified as the major early producers of IL-17A that orchestrate an inflammatory response in the burn model.These data suggest that IL-17A blockage may provide a unique target for therapeutic intervention to treat intestinal insult after burn. | Yajun Song Yang Li Ya Xiao Wengang Hu Xu Wang Pei Wang Xiaorong Zhang Jiacai Yang Yong Huang Weifeng He Chibing Huang | 2019 | Burns & Trauma2019，7，1： | 5 |
| 3 | Osteosarcoma metastasis: prospective role of ezrin显示文摘 | Yuanjin Zhang Ling Zhang Guofu Zhang Songbai Li Jun Duan Jie Cheng Guozhen Ding Chibing Zhou Jie Zhang Pengcheng Luo Dongbing Cai Lianghong Kuang Yichun Zhou Liqun Tong Xiangdong Yu Lifang Zhang Lijun Xu Li Yu Xiaomei Shi Aihong Ke | 2014 | Tumor Biology2014，，6： | 1 |
| 4 | Dynamic etching method for fabrication a variety of tip shapes in the optical fibre probe of a scanning near-field optical microscope显示文摘 | Muramatsu H Homma K Chibe N | 1999 | J Microsc1999，194，2： | 1 |
| 5 | Product form identification technology based on cognitive thinking 显示文摘 | Zhang Shutao Su Jianning Hu Chibing | 2013 | Telkomnika2013，11，10： | 1 |
| 6 | Simo decoction promotes contrac- tion of antral circular smooth muscle mainly via muscarinic M3 recep- tor显示文摘 | Chibing Dai Na Liu Wenmei Chen | 2012 | Journal of Ethnopharmacology2012，144，2： | 1 |
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