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| 1 | Smad3 knock-out mice as a useful model to study intestinal fibrogenesis显示文摘瞄准:为了在形态学和免疫评估可能的差别, CD3,转变生长因素 beta1 (TGF-beta1 ) , Smad7, alpha 光滑的肌肉肌动朊(alpha-Sma ) ,和骨胶原的组织化学的表示打 I-VII 小并且在 Smad3 空、野类型的老鼠的大肠。方法:十 0 和十只野类型的成年老鼠在年龄和机关的 4 瞬间被牺牲(食管,小、大的肠,输尿管) 为组织学被收集(苏木精和曙红,马森 thrichrome,染色的银) ,形态测定法和免疫组织化学分析。肠的织物 homogenates 的 TGF-beta1 层次被 ELISA 估计。结果:没有宏观的肠的损害在空、野类型的老鼠两个都被检测。组织学并且 morphometric 评估在肌肉层厚度揭示了重要减小小并且在空老鼠的大肠同样与野类型的老鼠相比。Immunohistochemistry 评估显示出染色在的 CD3+ T 房间, TGF-beta1 和 Smad7 的重要增加小并且 Smad3 空老鼠的大肠粘膜同样与野类型的老鼠相比。染色的 Alpha-Sma 和骨胶原 I-VII 小并且大肠没在二组老鼠之间不同。结肠的织物 homogenates 的 TGF-beta1 层次比在野类型的老鼠在空老鼠是显著地更高的。在初步的实验,导致 TNBS 的肠的纤维变性的重要减小作为与野类型的老鼠相比在空老鼠被观察。结论:Smad3 空老鼠是一个有用模型调查在肠的发炎和纤维变性表明小径的 TGF-beta/Smad 的在活体内角色。 | Giuliana Zanninelli Antonella Vetuschi Roberta Sferra Angela D'Angelo Amato Fratticci Maria Adelaide Continenza Maria Chiaramonte Eugenio Gaudio Renzo Caprilli Giovanni Latella | 2006 | World Journal of Gastroenterology2006，12，8： | 3 |
| 2 | Opposing regulatory roles of complement factor 5 in the development of bleomycin-induced pulmonary fibrosis显示文摘 | ADDIS-LIESER E KOHL J CHIARAMONTE MG | 2005 | J Immunol2005，175，3： | 1 |
| 3 | Regulation of hepatic fibrosis and extracellular matrix genes by the Th response:new insight into the role of tissue inhibitors of matrix metallo-proteinases 显示文摘 | VAILLANT B CHIARAMONTE M G CHEEVER A W | 2001 | J Immunol2001，167，12： | 1 |
| 4 | An IL-13 inhibitor blocks the development of hepatic fibrosis during a T- helper type 2-dominated inflammatory response 显示文摘 | Chiaramonte MG Donaldson DD Cheerer AW | 1999 | J Clin Invest1999，104，6： | 1 |
| 5 | An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2- dominated inflammatory response 显示文摘 | Chiaramonte MG Donaldson DD Cheever AW | 1999 | J Clin Invest1999，104，6： | 1 |
| 6 | Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response显示文摘 | Chiaramonte MG Mentink--Kane M Jacobson BA | 2003 | J Exp Med2003，197，6： | 1 |
| 7 | Interleukin-13 in asthma 显示文摘 | Wills-Karp M Chiaramonte M | 2003 | Curr Opin Pulm Med2003，9，1： | 1 |
| 8 | Senescence-dependentregulation of type 1 plasminogen activator inhibitor in human vascular endothelial cells显示文摘 | Chiaramonte R Maier JA | 1995 | Exp Cell Res1995，219，1： | 1 |
| 9 | The Vicenza 'Short' peritoneal catheter:a twenty year experience显示文摘 | Dell'Aquila R Chiaramonte S Rodighiero M P | | 0，，： | 1 |
| 10 | An IL-13 inhibitor blocks the development of hepatic fi- brosisi during a T-helper type 2-dominated inflammatory response显示文摘 | Chiaramonte MG Donaldson DD Cheever AW | 1999 | J Clin Invest1999，104，6： | 1 |
| 11 | Reciprocal regulation of Notch and PI3K/Akt signalling in T-ALL cells in vitro显示文摘 | Cahavara E Chiaramonte R Cesana D | 2008 | J Cell Biochem2008，103，5： | 1 |
| 12 | Ovarian cysts in newborns显示文摘 | Chiaramonte C Piscopo A Catalitti F | 2001 | Pediatr Surg Int2001，17，23： | 1 |
| 13 | Public perception of food allergy显示文摘 | Ahman DR Chiaramonte LT | 1996 | J Allergy Clin Immunol1996，97，： | 1 |
| 14 | Microproteinuria as a marker of renal damage in children 显示文摘 | Chiaramonte C Cigna RM Cataliotti F | 2002 | Minerva Urol Nephrol2002，54，4： | 1 |
| 15 | Chron- ic hepatitis D: a vanishing disease? An Italian multicenter study 显示文摘 | GAETA GB STROFFOLINI T CHIARAMONTE M | 2000 | Hepatology2000，32，41： | 1 |
| 16 | Long-term oral plus topical mesalazine in frequently relapsing ulcerative colitis显示文摘 | G. Frieri M. Pimpo B. Galletti G. Palumbo G. Corrao G. Latella M. Chiaramonte R. Caprilli | 2004 | Digestive and Liver Disease2004，，： | 1 |
| 17 | Opposing regulatory roles of complement factor 5 in the development of bleomycin induced pulmonary fibrosis显示文摘 | Addis-Lieser E Kohl J Chiaramonte M G | 2005 | J Immunol2005，175，3： | 1 |
| 18 | Regulation and function of the interleukin 13 receptor α2 during a T helper cell type 2-dominant immune response 显示文摘 | Chiaramonte MG Mentink-Kane Jacobson BA | 2003 | J Exp Med2003，197，70： | 1 |
| 19 | Primary biliary cirrhosis in the elderly 显示文摘 | Floreani A Chiaramonte M Fabris P | 1991 | Recenti Prog Med1991，82，5： | 1 |
| 20 | Regulation of he- patic fibrosis and extracellular matrix genes by the th response : new insight into the role of tissue inhibitors of matrix metalloproteinases 显示文摘 | Vaillant B Chiaramonte MG Cheerer AW | 2001 | J Immunol2001，167，12： | 1 |
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