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| 1 | Role of nitric oxide in the impairment of circular muscle contractility of distended, uninflamed mid-colon in TNBS-induced acute distal colitis in rats显示文摘AIM: To evaluate the role of nitric oxide (NO) in the motor disorders of the dilated uninflamed mid-colon (DUMC)from trinitrobenzene sulfonic acid (TNBS)-induced acute distal colitis in rats.METHODS: Colitis was induced in male Sprague-Dawley rats by a single intracolonic administration of TNBS.Control rats received an enema of 0.9% saline. The rats were killed 48 h after TNBS or saline administration.Macroscopic and histologic lesions of the colon were evaluated. Myeloperoxidase (MPO) and nitric oxide synthase (NOS) activity were measured on the colonic tissue. In TNBS rats, we evaluated spontaneous and evoked contractile activity in circular muscle strips derived from DUMC in comparison to the same colonic segment of control rats, both in the presence and in the absence of a non-selective NOS isoforms inhibitor N-nitro-Larginine (L-NNA). Pharmacological characterization of electric field stimulation (EFS)-evoked contractile responses was also performed.RESULTS: In TNBS rats, the distal colon showed severe histological lesions and a high MPO activity, while the DUMC exhibited normal histology and MPO activity.Constitutive NOS activity was similar in TNBS and control rats, whereas inducible NOS activity was significantly increased only in the injured distal colon of TNBS rats.Isometrically recorded mechanical activity of circular muscle strips from DUMC of TNBS rats showed a marked reduction of the force and frequency of spontaneous contractions compared to controls, as well as of the contractile responses to a contracting stimulus. In the presence of L-NNA, the contractile activity and responses displayed a significantly greater enhancement compared to controls. The pharmacological characterization of EFS contractile responses showed that a cooperative-like interaction between cholinergic muscarinic and tachykinergic neurokinin 1 and 2 receptors mediated transmission in DUMC of TNBS rats vs a simple additive interaction in controls.CONCLUSION: The results of this study show that, during TNBS-induced acute distal colitis, circular muscle intrinsic contractile mechanisms and possible enteric neural excitatory activity are inhibited in the distended uninflamed mid-colon. Suppression of NO synthesis markedly improves spontaneous and evokes muscle contractions, in spite of any evident change in local NO activity. | Luciano Onori Annalisa Aggio Simona D'Alo' Paola Muzi Maria Grazia Cifone Gabriella Mellillo Rachele Ciccocioppo Gennaro Taddei Giuseppe Frieri Giovanni Latella | 2005 | World Journal of Gastroenterology2005，11，36： | 7 |
| 2 | Influence of im- purity elements on electrochemical activity of aluminum activated by indium显示文摘 | Breslin C B Friery L P Carroll W M | 1993 | Corrosion1993，49，11： | 1 |
| 3 | Treatment update for allergic rhinitis显示文摘 | Frieri M | 2000 | Allergy Asthma Proc2000，21，6： | 1 |
| 4 | Efficacy of novel monoclonal antibody belimumab in the treatment of lupus nephritis显示文摘 | Frieri M Heuser W Bliss J | 2015 | J Pharmacol Pharmaeother2015，6，2： | 1 |
| 5 | Neuroimmunology and inflammation:implications for therapy of allergic and autoimmune diseases显示文摘 | Frieri M | 2003 | Ann Allergy Asthma Immunol2003，90，6： | 1 |
| 6 | Long-term oral plus topical mesalazine in frequently relapsing ulcerative colitis显示文摘 | G. Frieri M. Pimpo B. Galletti G. Palumbo G. Corrao G. Latella M. Chiaramonte R. Caprilli | 2004 | Digestive and Liver Disease2004，，： | 1 |
| 7 | The role of Vitamin D in asthmatic children 显示文摘 | Frieri M | 2011 | Curr Allergy Asthma Rep2011，11，： | 1 |
| 8 | Toll-like receptor 9 and vascular endothelial growth factor levels in human kidneys from lupus nephritis patients显示文摘 | Frieri M Samih MA Dzhindzhikhashvili M | | 0，，06： | 1 |
| 9 | Bacterial biofilms and chronic rhinosinusi-tis显示文摘 | MADEO J FRIERI M | 2013 | Allergy Asthma Proc2013，34，4： | 1 |
| 10 | Review : Immunology of sinusitis, trau- ma, asthma, and sepsis 显示文摘 | Frieri M Kumar K Boutin A | 2015 | Allergy Rhinol ( Providence)2015，6，3： | 1 |
| 11 | Long-term oral plus topical mesalazine in frequently relapsing ulcerative colitis显示文摘 | G. Frieri M. Pimpo B. Galletti G. Palumbo G. Corrao G. Latella M. Chiaramonte R. Caprilli | 2004 | Digestive and Liver Disease2004，，2： | 1 |
| 12 | Mechanisms of disease for the clinician:systemic lupus erythematosus显示文摘 | Frieri M | | 0，，： | 1 |
| 13 | Mucosal 5-aminosalicylic acid concentration inversely correlates with severity of colonic inflammation in patients with ulcerative colitis显示文摘 | Frieri G Giacomelli R Pimpo M | 2000 | Gut2000，47，3： | 1 |
| 14 | Rectal and colonic mesalazinc concentration in ulcerative colitis:oral versus oral plus topical treatment显示文摘 | Frieri G Pimpo MT Palumbo GC | 1999 | Aliment Pharmacol Ther1999，13，11： | 1 |
| 15 | Assessment of inflammatory activity in Crohn's disease by means of dynamic contrast - enhanced MRI 显示文摘 | Pupillo VA Di Cesare E Frieri G | 2007 | Radiol Med(Torino)2007，112，6： | 1 |
| 16 | The T-cell immunoglobulin and mucin domain (Tim) gene family in asthma, allergy, and autoimmunity显示文摘 | Li 2 Ju 2 Frieri M | 2013 | Allergy Asthma Proc2013，，： | 1 |
| 17 | Neuroimmunology and inflammation:implications for therapy of allergic and autoimmune diseases显示文摘 | Frieri M | 2003 | Ann Allergy Asthma Immunol2003，90，： | 1 |
| 18 | Nitric oxide in allergic rhinitis and asthma显示文摘 | Frieri M | 1998 | Allergy Asthma Proe1998，19，： | 1 |
| 19 | Mechanisms of disease for the clinician: systemiclupus eryt-hematosus显示文摘 | Frieri M | 2013 | Ann Allergy Asthma Immunol2013，110，4： | 1 |
| 20 | Lupus nephritis: review of the literature显示文摘 | Zubair A Frieri M | 2013 | Curr Allergy Asthma Rep2013，13，6： | 1 |
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