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| 1 | T4 cervical esophageal cancer cured with modern chemoradiotherapy: A case report显示文摘BACKGROUND T4 esophageal cancer portends a poor prognosis,particularly when it is complicated by a tracheoesophageal fistula(TEF)either resulting from disease or occurring as a complication of treatment.Patients with TEF that occurs during treatment are commonly treated with palliative intent because fistula-associated treatment complications such as aspiration pneumonia and mediastinitis are associated with high morbidity and mortality.To date,there is no clear evidence on the optimal treatment of T4 esophageal cancer,particularly when a TEF formation occurs.CASE SUMMARY A 67-year-old gentleman who presented with dysphagia and weight loss.Endoscopy and imaging revealed a T4N1M0 cervical esophageal squamous cell carcinoma.He received image-guided intensity-modulated radiation therapy,with concurrent weekly carboplatin(area under curve 2 mg/mL per minute)and paclitaxel(50 mg/m2 of body surface area).One week after treatment initiation(16.2 Gy thus far),he developed cough on swallowing.A TEF was detected on image-guided radiation therapy using cone-beam computed tomography during the treatment course,for which a tracheal stent was inserted.After discussing the risks and morbidity of continuing treatment,he resumed chemoradiotherapy with an additional radiation dose of 45 Gy in 25 fractions.Three months after completion of chemoradiotherapy,he developed an esophageal stricture that required esophageal stenting and dilatation.The patient remains cancer-free at two year on follow-up.Complete response of esophageal cancer was evident on post-treatment endoscopy and computed tomography imaging,with successful closure of TEF.CONCLUSION This case highlights that successful curative treatment for esophageal cancer complicated by a TEF is possible using novel chemotherapeutic regimens and modern radiation technologies. | Chia Ching Lee Chong Ming Yeo Wee Khoon Ng Akash Verma Jeremy CS Tey | 2020 | World Journal of Clinical Cases2020，8，10： | 2 |
| 2 | Tripeptide inhibitors ofdengue and West Nile virus NS2B NS3 protease显示文摘 | Schtiller A Yin Z Brian chia CS | 2011 | Antiviral Res2011，92，1： | 1 |
| 3 | Combining grey relation analysis and entropy model for evalu- ating the operational performance: An empirical study 显示文摘 | Chia CS | 2014 | Qual Quant2014，48，5： | 1 |
| 4 | Expression of interleukin- 18, interferon-3, and interleukin-10 in hepatocellular carcinoma显示文摘 | Chia CS Ban K Ithnin H | 2002 | Immunol Lett2002，84，3： | 1 |
| 5 | Expression of interleukin-18,interferon-gamma and interleukin-10 in hepatocellular carcinoma显示文摘 | Chia CS Ban K Ithnin H | | 0，，： | 1 |
| 6 | Incidence, mortality and five- year relative survival ratio of prostate cancer among Chinese residents in Singapore from 1968 to 2002 by metastatic staging 显示文摘 | Chia SE Tan CS Lim GH | 2010 | Ann Acad Med Singapore2010，39，6： | 1 |
| 7 | Expression of interleukin-18, interferon-gamma and interleukin-10 in hepatocellular carcinoma显示文摘 | Chia CS Ban K Ithnin H | 2002 | Immunol Lett2002，84，： | 1 |
| 8 | Thallium acetate induces c6 glioma cell apoptosis显示文摘 | Chia CF Chen SC Chen CS | 2005 | Ann N Y Acad Sci2005，1042，： | 1 |
| 9 | Profound changes in breast cancer incidence may reflect changes into a Westernized lifestyle:a comparative population-based study in Singapore and Sweden显示文摘 | Chia KS Reilly M Tan CS | 2005 | Int J Cancer2005，113，2： | 1 |
| 10 | The lipoprotein lipase S447X polymorphism and plasma lipids:interactions with APOE polymorphisms,smoking,and alcohol consumption显示文摘 | Lee J Tan CS Chia KS | 2004 | J Lipid Res2004，45，6： | 1 |
| 11 | The lipoprotein lipase S447X polymorphism and plasma lipids: interactions with APOE polymorphisms, smoking, and alcohol consumption 显示文摘 | Lee J Tan CS Chia KS | 2004 | J Lipid Res2004，45，6： | 1 |
| 12 | The lipoprotein lipase S447X polymorphism and plasmalipids: interactions with APOE polymorphisms, smoking, and alcohol consumption显示文摘 | Lee J Tan CS Chia KS a al | 2004 | J Lipid Res2004，45，2： | 1 |
| 13 | Eradication of helicobacter py- lori for prevention of ulcer recurrence after simple closure of perfo- rated peptic ulcer: A meta-analysis of randomized controlled trials 显示文摘 | Wong CS Chia CF Lee I-IC | 2013 | J Surg Res2013，182，2： | 1 |
| 14 | Salivary and serum antibody response to Streptococcus mutans antigens in humans显示文摘 | Chia JS Chang WC Yang CS | 2000 | Oral Microbiol Immunol2000，15，2： | 1 |
| 15 | Quality of life after cytmduc- tire surgery and hyperthermic intraperitoneal chemotherapy: an Asian perspective 显示文摘 | Tan W J Wong JF Chia CS | 2013 | Ann Surg Oncol2013，20，13： | 1 |
| 16 | Development of a multiplex PCR and SHV melting curve mutation detection system for detection of some SHV and CTX-M β-lactamases of Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae in Taiwan显示文摘 | Chia JH Chu CS Su LH | 2005 | J Clin Microbiol2005，43，9： | 1 |
| 17 | Expression of interleukin-18,interferon-gamma and interleukin-10 in hepatocellular carcinoma显示文摘 | Chia CS Ban K Ithnin H | 2002 | Immunol Lett2002，84，3： | 1 |
| 18 | Eradication of Helicobacter pylori for prevention of ulcer recurrence after simple closure of perforated peptic ulcer: A meta-analysis of randomized controlled trials显示文摘 | Wong CS Chia CELee HC | 2013 | J Surg Res2013，182，2： | 1 |
| 19 | Quality of life in patients with peri- toneal surface malignancies after cytoreductive surgery and hyperther- mic intraperitoneal chemotherapy 显示文摘 | Chia CS Tan WJ Wong JF | 2014 | Eur J Surg Oncol2014，40，8： | 1 |
| 20 | Functional analyses of a conserved region in glucosyltransferases of Streptococcus mutans 显示文摘 | Chia JS Yang CS Chen JY | 1998 | Infect Immun1998，66，10： | 1 |
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