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您的检索式：作者名="Akash Verma"
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| 1 | T4 cervical esophageal cancer cured with modern chemoradiotherapy: A case report显示文摘BACKGROUND T4 esophageal cancer portends a poor prognosis,particularly when it is complicated by a tracheoesophageal fistula(TEF)either resulting from disease or occurring as a complication of treatment.Patients with TEF that occurs during treatment are commonly treated with palliative intent because fistula-associated treatment complications such as aspiration pneumonia and mediastinitis are associated with high morbidity and mortality.To date,there is no clear evidence on the optimal treatment of T4 esophageal cancer,particularly when a TEF formation occurs.CASE SUMMARY A 67-year-old gentleman who presented with dysphagia and weight loss.Endoscopy and imaging revealed a T4N1M0 cervical esophageal squamous cell carcinoma.He received image-guided intensity-modulated radiation therapy,with concurrent weekly carboplatin(area under curve 2 mg/mL per minute)and paclitaxel(50 mg/m2 of body surface area).One week after treatment initiation(16.2 Gy thus far),he developed cough on swallowing.A TEF was detected on image-guided radiation therapy using cone-beam computed tomography during the treatment course,for which a tracheal stent was inserted.After discussing the risks and morbidity of continuing treatment,he resumed chemoradiotherapy with an additional radiation dose of 45 Gy in 25 fractions.Three months after completion of chemoradiotherapy,he developed an esophageal stricture that required esophageal stenting and dilatation.The patient remains cancer-free at two year on follow-up.Complete response of esophageal cancer was evident on post-treatment endoscopy and computed tomography imaging,with successful closure of TEF.CONCLUSION This case highlights that successful curative treatment for esophageal cancer complicated by a TEF is possible using novel chemotherapeutic regimens and modern radiation technologies. | Chia Ching Lee Chong Ming Yeo Wee Khoon Ng Akash Verma Jeremy CS Tey | 2020 | World Journal of Clinical Cases2020，8，10： | 2 |
| 2 | Atrial fibrillation and coronary artery disease:An integrative review focusing on therapeutic implications of this relationship显示文摘The incidence of both atrial fibrillation(AF)and coronary artery disease(CAD)increases with advancing age.They share common risk factors and very often coexist.Evidence points to an intricate relationship between atrial tissue excitability and neuronal remodeling with ischemia at the microcirculatory level.In this review,we delineated this complex relationship,identified a common theme between the two,and discussed how the knowledge of this relationship translates into a positive and meaningful impact in patient management.Recent research indicates a high prevalence of CAD among AF patients undergoing coronary angiography.Further,the incidence of AF is much higher in those suffering from CAD compared to age-matched adults without CAD underlying this reciprocal relationship.CAD adversely affects AF by promoting progression via re-entry and increasing excitability of atrial tissue as a result of ischemia and electrical inhomogeneity.AF in turn accelerates atherosclerosis via endothelial dysfunctional and inflammation and together with enhanced thrombogenicity and hypercoagulability contribute to micro and macrothrombi throughout cardiovascular system.In a nutshell,the two form a vicious cycle wherein one disease promotes the other.Most AF recommendations focuses on rate/rhythm control and prevention of thromboembolism.Very few studies have discussed the importance of unmasking coexistent CAD and how the treatment of underlying ischemia will impact the burden of AF in these patients.Inflammation and endothelial dysfunction remain central to both disease processes and form a handsome therapeutic target in the management of the two diseases.The relationship between AF and CAD is complex and much more than mere coincidence.The two diseases share common risk factor and pathophysiology.Hence,it is impractical to treat them in isolation.Accordingly,we share the implications of managing underlying ischemia and inflammation to positively impact and improve quality of life among AF patients. | Akash Batta Juniali Hatwal Akshey Batta Samman Verma Yash Paul Sharma | 2023 | World Journal of Cardiology2023，15，5： | 1 |
| 3 | Ground bounce noise reduction aware combinational multi threshold CMOS circuits for nanoscale CMOS multiplier显示文摘多阀值互补 metal-oxide-semiconductor (MTCMOS ) 经常被用来在闲散电路减少漏水流。地面弹起在一个转变模式(sleep-to-active ) 期间生产的噪音是在 MTCMOS 的重要挑战。在这份报纸,各种各样的噪音知道的 combinational MTCMOS 电路被用来评估地面弹起噪音。一个中间的模式在 sleep-to-active 模式转变被使用减少在虚拟线上存储到真实地面的费用。地面的依赖弹起电压,晶体管尺寸和温度上的噪音与不同 MTCMOS 被调查电路技术。地面的山峰振幅弹起噪音被减少直到 78.82% 。电路的漏电流被减少直到 99.73% ,电路的活跃力量被减少直到 62.32% 。模拟更多样地,与不同 MTCMOS,电路技术在 45 nm 互补金属氧化物半导体技术上被执行。 | Bipin Kumar VERMA Shyam Babu SINGH Shyam AKASHE | 2013 | Frontiers of Optoelectronics2013，6，3： | 0 |
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