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| 1 | 配电网大数据技术分析与典型应用案例(英文)显示文摘以美国Auto Grid公司及其2个产品(能量数据平台EDP和需求侧优化管理系统DROMS)为例,分析了大数据技术在配电网数据分析中的应用。首先,简要介绍了主动配电网中大数据的典型特点;然后列举了EDP和DROMS的关键技术和主要功能,并介绍了Auto Grid公司的4个典型应用案例;最后,结合配电网的设备水平和运行水平,总结归纳了配电网大数据应用的关键技术,提出配电网大数据应用的实施路线图。 | 王璟 杨德昌 李锰 范征 Mark Chew | 2015 | 电网技术2015，39，11： | 29 |
| 2 | Conventional processes and membrane technology for carbon dioxide removal from natural gas:A review显示文摘Membrane technology is becoming more important for CO 2 separation from natural gas in the new era due to its process simplicity,relative ease of operation and control,compact,and easy to scale up as compared with conventional processes.Conventional processes such as absorption and adsorption for CO 2 separation from natural gas are generally more energy demanding and costly for both operation and maintenance.Polymeric membranes are the current commercial membranes used for CO 2 separation from natural gas.However,polymeric membranes possess drawbacks such as low permeability and selectivity,plasticization at high temperatures,as well as insufficient thermal and chemical stability.The shortcomings of commercial polymeric membranes have motivated researchers to opt for other alternatives,especially inorganic membranes due to their higher thermal stability,good chemical resistance to solvents,high mechanical strength and long lifetime.Surface modifications can be utilized in inorganic membranes to further enhance the selectivity,permeability or catalytic activities of the membrane.This paper is to provide a comprehensive review on gas separation,comparing membrane technology with other conventional methods of recovering CO 2 from natural gas,challenges of current commercial polymeric membranes and inorganic membranes for CO 2 removal and membrane surface modification for improved selectivity. | Zee Ying Yeo Thiam Leng Chew Abdul Rahman Mohamed Siang-Piao Chai | 2012 | Journal of Natural Gas Chemistry2012，21，3： | 17 |
| 3 | Effects of miR-219/miR-338 on microglia and astrocyte behaviors and astrocyte-oligodendrocyte precursor cell interactions显示文摘MiR-219 and miR-338(miR-219/miR-338)are oligodendrocyte-specific microRNAs.The overexpression of these miRs in oligodendrocyte precursor cells promotes their differentiation and maturation into oligodendrocytes,which may enhance axonal remyelination after nerve injuries in the central nervous system(CNS).As such,the delivery of miR-219/miR-338 to the CNS to promote oligodendrocyte precursor cell differentiation,maturation and myelination could be a promising approach for nerve repair.However,nerve injuries in the CNS also involve other cell types,such as microglia and astrocytes.Herein,we investigated the effects of miR-219/miR-338 treatment on microglia and astrocytes in vitro and in vivo.We found that miR-219/miR-338 diminished microglial expression of pro-inflammatory cytokines and suppressed astrocyte activation.In addition,we showed that miR-219/miR-338 enhanced oligodendrocyte precursor cell differentiation and maturation in a scratch assay paradigm that re-created a nerve injury condition in vitro.Collectively,our results suggest miR-219/miR-338 as a promising treatment for axonal remyelination in the CNS following nerve injuries.All experimental procedures were approved by the Institutional Animal Care and Use Committee(IACUC),Nanyang Technological University(approval No.A0309 and A0333)on April 27,2016 and October 8,2016. | Lan Huong Nguyen William Ong Kai Wang Mingfeng Wang Dean Nizetic Sing Yian Chew | 2020 | Neural Regeneration Research2020，15，4： | 11 |
| 4 | Microglial migration mediated by ATP-induced ATP release from lysosomes显示文摘Microglia 是在中央神经系统充当活跃有免疫力的防卫的主要形式的高度能动的房间。由免除损坏房间的因素吸引了, microglia 向损坏或感染的地点被招募,在他们涉及退化、再生的回答和房间碎片的 phagocytotic 清理的地方。从损坏神经纸巾的 ATP 版本被建议了调停向损害的地点的 microglial 过程的快速的延期。然而, microglia 的远程的迁居的机制尚待被澄清。这里,我们发现在 microglia 的 lysosomes 响应各种各样的刺激包含丰富的 ATP 和展览 Ca 2+-dependent exocytosis。由建立一在 vitro 趋化性试金有效,我们证明从 microglia 的 释放endogenously 的 ATP 由 ATPγ 的本地 microinjection 被触发; S 为 microglia 的远程的趋化性是批评的,显著地在与导致 lysosome osmodialysis 的一个代理人或在房间对待的 microglia 被禁止的回答源于在 Rab 27a (灰老鼠)缺乏的老鼠,为能分泌的 lysosomes 的 trafficking 和 exocytosis 要求的小 GTPase 。这些结果建议 microglia 由通过 lysosomal exocytosis 自己释放 ATP 对细胞外的 ATP 作出回应,从而提供积极反馈机制为吸引远 microglia 移居向并且在损害的地点积累产生一个远程的细胞外的信号。 | Ying Dou Hang-jun wu Hui-quan Li Song Qin Yin-er Wang Jing Li Hui-fang LOU Zhong Chew Xiao-ming Li Qing-ming Luo Shumin Duan | 2012 | Cell Research2012，22，6： | 10 |
| 5 | Hypoxia increases adipogenesis and affects adipocytokine production in orbital fibroblasts-a possible explanation of the link between smoking and Graves' ophthalmopathy显示文摘AIM:To assess the effects of hypoxia on human orbital fibroblasts(OF)on adipogenesis and adipocytokine production.METHODS:Human OF were derived from tissues obtained from patients with Graves'ophthalmopathy(GO)and from patients without known thyroid diseases undergoing blepharoplasty.The OF were cultured separately under normoxic and hypoxic conditions.Comparisons of adipocytokine concentrations using multiplex ELISA and lipid accumulation in the cells using Oil Red O staining were subsequently performed.RESULTS:There was increased adipogenesis in OF from GO subject when exposed to hypoxic culture conditions.This was not observed in OF from normal controls.Hypoxia led to an increase in leptin and a decrease in MCP-1 secretion in OF cultures.CONCLUSION:Hypoxia induces adipogenesis in OF and may represent a mechanism by which smoking contributes to deterioration of GO.We also found novel changes to leptin and MCP-1 production in OF cultures exposed to hypoxia suggesting important roles of these cytokines in the disease process. | Chiaw Ling Chng Oi Fah Lai Charmaine Sze-Min Chew Yu Pei Peh Stephanie Man-Chung Fook-Chong Lay Leng Seah Daphne Hsu-Chin Khoo | 2014 | International Journal of Ophthalmology(English edition)2014，7，3： | 10 |
| 6 | 中亚造山带东南缘二叠纪-三叠纪花岗质岩浆演化对增生-碰撞过程的制约显示文摘全球许多造山带都不同程度地经历了增生和碰撞造山阶段,作为全球最大的显生宙增生型造山带,中亚造山带是如何从俯冲增生演化到碰撞拼合是一个值得探究的问题.文章报道了位于中亚造山带东南缘内蒙古中部地区二叠纪-三叠纪花岗岩新的锆石U-Pb年龄(266~235Ma)、地球化学和同位素数据,并系统梳理了区域内已有资料,从岩浆性质随时间演化的角度,厘定出该地区从早二叠世俯冲到晚二叠世(软)碰撞的构造-岩浆演化特征.从早二叠世到晚二叠世,花岗岩类全岩εNd(t)值和锆石εHf(t)值逐渐从正值演化到出现负值(ε_(Nd)(t)值:2.4~-19.5;εHf(t)值:11.6~-33.7),表明从增生演化到碰撞阶段,岩浆源区的古老陆壳组分逐渐增多.结合区域资料,进一步确认了中亚造山带演化到晚期发生(软)碰撞的岩浆标志为仅沿索伦-西拉木伦缝合带零星线性展布的增厚下地壳来源的中-晚二叠世至中三叠世高Sr/Y花岗岩类.同时,沿索伦-西拉木伦缝合带自西向东,增生-碰撞转换时期的花岗质岩浆活动的峰期年龄分别为约264和251Ma,也反映了古亚洲洋自西向东'剪刀'状闭合的过程.综合前人研究,将中亚造山带东南缘二叠纪至三叠纪从增生到碰撞的岩浆-构造演化过程总结为三个阶段.(1)早二叠世(约285Ma前):古亚洲洋双向俯冲,新生弧岩浆作用发育阶段;(2)中二叠世到中三叠世(约285~235Ma):俯冲增生到碰撞拼合的构造-岩浆转换阶段,由于造山带挤压汇聚导致板片断离而引发岩浆物源从年轻地壳向古老地壳转变;(3)晚三叠世(约235Ma后),后造山伸展相关的A型花岗岩和碱性岩浆作用发育阶段. | 吴迪迪 李舢 David CHEW 刘铁翊 郭东海 | 2021 | 中国科学:地球科学2021，51，6： | 10 |
| 7 | Microalgae:A potential alternative to health supplementation for humans显示文摘Microalgae has been consumed in human diet for thousands of years.It is an under-exploited crop for production of dietary foods.Microalgae cultivation does not compete with land and resources required for traditional crops and has a superior yield compared to terrestrial crops.Its high protein content has exhibited a huge potential to meet the dietary requirements of growing population.Apart from being a source of protein,presence of various bio-active components in microalgae provide an added health benefit.This review describes various microalgal sources of proteins and other bio-active components.One of the heavily studied group of bio-active components are pigments due to their anticarcenogenic,antioxidative and antihypertensive properties.Compared to various plant and floral species,microalgae contain higher amounts of pigments.Microalgal derived proteins have complete Essential Amino Acids(EAA)profiles and their protein content is higher than conventional sources such as meat,poultry and dairy products.However,microalgal based functional foods have not flooded the market.The lack of awareness coupled with scarce incentives for producers result in under-exploitation of microalgal potential.Application of microalgal derived components as dietary and nutraceutical supplements is discussed comprehensively. | Apurav Krishna Koyande Kit Wayne Chew Krishnamoorthy Rambabu Yang Tao Dinh-Toi Chu Pau-Loke Show | 2019 | Food Science and Human Wellness2019，8，1： | 10 |
| 8 | 施工现场安全危险源实时监控与安全风险预测方法研究显示文摘对国内外建筑业施工现场安全风险的研究进行了文献综述,针对目前研究的不足之处,提出了施工现场安全危险源实时监控和安全风险实时预测的示意性模型,并详细解释了该模型的含义和方法。研究将提供一种基于前馈信号的施工现场安全危险源实时监控和安全风险实时预测的方法;并通过将现有研究的视角引入到施工现场关键安全危险源的前馈信号上,为进一步的研究打下良好的理论基础。 | 吴伟巍 Patrick T.I. LAM 李启明 Michael C.H. YAM David A.S. CHEW | 2010 | 中国工程科学2010，12，3： | 9 |
| 9 | The breast tumor microenvironment alters the phenotype and function of natural killer cells显示文摘生来的杀手(NK ) 房间是有识别并且消除转变房间的能力的天生的有免疫力的房间。在肿瘤以内,然而,许多研究把 NK 房间描述了为非功能。联系肿瘤的 NK 房间的发展阶段并且这怎么可以联系到功能,没被探索。我们从 polyoma 中间 T 抗原(pyMT ) 检验了 NK 房间的发展状态转基因的老鼠(MMTV-pMT ) 胸肿瘤。在 pyMT 肿瘤, NK 房间是不成熟的是由他们 DX5 和他们的 CD27 低 CD11b 低 显型。这些不成熟的 NK 房间也增加了 NKG2A 的表示并且表示了 NKp46, perforin,和 granzyme B 的底层。相反,从一样的老鼠孤立的脾的 NK 房间维持了他们的成熟和他们激活标记的表示。描出肿瘤微型环境是否直接改变 NK 房间,我们采纳地转移了标记的 NK 房间并且在怒气和肿瘤跟随了他们的激活地位。到达了肿瘤的 NK 房间与到达了怒气的那些相比在三天转移以内有 NKp46 的半表示。以修改肿瘤微型环境并且估计 intratumoral NK 房间的粘性,我们与 IL-12 和 anti-TGF-β 治疗了 pyMT 肿瘤;。在一星期处理以后,联系肿瘤的 NK 房间的成熟被增加;因此,显示这些房间拥有能力成熟并且变得激活。NK 房间怎么被肿瘤微型环境修改的更好的理解将帮助开发策略的 A 瞄准了对肿瘤支持有免疫力的回答。 | Tamara Krnetal Amy Gillgrass Marianne Chew Ali A. Ashkar | 2016 | Cellular & Molecular Immunology2016，13，5： | 7 |
| 10 | Post-operative strabismus control and motor alignment for basic intermittent exotropia显示文摘AIM:To assess strabismus control and motor ocular alignment for basic exotropia surgery at 5y follow-up.METHODS:The medical records of 80 consecutive patients aged less than 17 years of age,who underwent surgery for basic exotropia by a single surgeon between years 2000 to 2009 and completed a minimum of 5y follow-up post-operatively were reviewed.Pre- and post-operative characteristics were documented at 1wk,6mo,1,3 and 5y follow-up.Subjects at 5-year follow-up were assigned to the success group if they had a postoperative angle of deviation within 10 prism diopters of exotropia or within 5 prism diopters of esotropia for distance on prism cover test,and had moderate to good strabismus control.The remaining subjects were assigned to the failure group.RESULTS:Post-operative surgical success at one week was 75%,which decreased to 41% at 5y follow-up.The success group was noted to have more patching pre-operatively(P=0.003).The duration of patching a day(P=0.020) and total duration of patching preoperatively(P=0.030) was higher in the success group.Surgical success at 1y(P=0.004) and 3y(P=0.002) were associated with higher surgical success at 5y follow-up.CONCLUSION:Post-operative motor alignment and strabismus control for basic exotropia surgery at 1y and beyond is associated with higher exotropia surgery success at 5-year follow-up.There is an association between pre-operative patching and 5-year surgical success of basic intermittent exotropia surgery. | Fiona Chew Lee Min Bhambi Uellyn Gesite-de Leon Boon Long Quah | 2016 | International Journal of Ophthalmology(English edition)2016，9，7： | 7 |
| 11 | Review of sustainability, pretreatment, and engineering considerations of asphalt modifiers from the industrial solid wastes显示文摘The escalating mass of solid waste at an overwhelming sum requires a global attention to strive for efficient waste management and to outsource the ecological treatments. The asphalt pavement industry that consumes a vast scale of natural resources while contributing to thermal and greenhouse emissions is viewed as a high potential alternative for the application of solid waste as asphalt modifier and substantial waste reduction. In efforts to urge for cleaner and greener asphalt production, a growing trend towards usage of solid waste as a renewable material is paving a sustainable future for the asphalt pavement industry. The economic options of incorporating solid waste into the asphaltic mixture coupled with proven effective performances are a green and cost-effective alternative to mitigate various pavement distresses. Various options either as coarse or fine aggregates and as fillers in powder, ash, or fibre form are to stimulate further research interest to incorporate a diversified range of solid waste into the asphalt binder and asphalt mixture. Prior to incorporating solid waste into the asphaltic mixture through the selected options, prerequisite tests in addressing engineering limitations due to the unknown properties of solid waste are reviewed. The concerns on environmental impact are given heavy metals leaching possibilities into water sources are addressed by Toxicity Characterization Leaching Procedure test, to leverage further the systematic reuse of solid waste in steering towards the cleaner production of the asphalt mixture. The microcosmic traits of solid waste namely surface morphology, mineralogical composition and chemical composition are summarized based on the usage of Scanning Electron Microscope, X-Ray Diffraction, and X-Ray Fluorescence, respectively. This systematic review is an enactment and stimulus for researchers to have a general overview before incorporating solid waste into asphalt mixture. | Mohd Rosli Mohd Hasan J-Wei Chew Ali Jamshidi Xu Yang Meor Othman Hamzah | 2019 | Journal of Traffic and Transportation Engineering(English Edition)2019，6，3： | 7 |
| 12 | Additive manufacturing of steel–copper functionally graded material with ultrahigh bonding strength显示文摘Additive manufacturing enables processing of functionally graded materials(FGMs)with flexible spatial design and high bonding strength.A steel-copper FGM with high interfacial strength was developed using laser powder bed fusion(LPBF).The effect of laser process parameters on interfacial defects was evaluated by X-ray tomography,which indicates a low porosity level of 0.042%therein.Gradient/fine dendritic grains in the interface are incited by high cooling rates,which facilitates interface strengthening.Multiple mechanical tests evaluate the bonding reliability of interface;and the fatigue tests further substantiate the ultrahigh bonding strength in FGMs,which is superior to traditional manufacturing methods.Mechanisms of the high interfacial bond strength were also discussed. | Chaolin Tan Youxiang Chew Guijun Bi Di Wang Wenyou Ma Yongqiang Yang Kesong Zhou | 2021 | Journal of Materials Science & Technology2021，，13： | 7 |
| 13 | Effects of Potassium and Manganese Promoters on Nitrogen-Doped Carbon Nanotube-Supported Iron Catalysts for CO_2 Hydrogenation显示文摘氮掺杂碳纳米管(NCNTs)作为载体负载铁(Fe)纳米颗粒,可应用于CO_2多相催化加氢反应(633 K和25 bar)。当将钾(K)和锰(Mn)作为助催化剂时,Fe/NCNT展现出优异的CO_2加氢性能,在体积空速(GHSV)为3.1 L·g^(–1)·h^(–1)时转化率可达34.9%。当使用K作为助催化剂时,反应对烯烃和短链烷烃具有高的选择性。当K和Mn同时作为助催化剂时,其催化活性能够稳定地维持60 h。助催化剂Mn的结构效应通过X射线衍射、氢气程序升温还原以及近边X射线吸收精细结构进行表征。助催化剂Mn不仅能够稳定中间态FeO,且能降低程序升温还原的起始温度。通过探针反应NH3的催化分解来表征助催化剂效应。当K和Mn作为助催化剂时,Fe/NCNT具有最好的催化活性。在还原条件下,当K作为助催化剂时,Fe/NCNT具有最优异的热稳定性。 | Praewpilin Kangvansura Ly May Chew Chanapa Kongmark Phatchada Santawaja Holger Ruland Wei Xia Hans Schulz Attera Worayingyong Martin Muhler | 2017 | Engineering2017，3，3： | 6 |
| 14 | Two Potent α3/5 Conotoxins from Piscivorous Conus achatinus显示文摘每个锥蜗牛生产不同 conotoxins 的混合物并且分泌他们使他们的猎物和食肉动物不能调动。α 3 /5 Conotoxins,从狩猎鱼的锥蜗牛孤立,目标肌肉烟碱的醋胆素受体。从食鱼的 Conus achatinus 的α 3 /5 conotoxin 的结构和功能没被学习。我们综合了二 pentadecamer 肽, Ac1.1a 和 Ac1.1b 与适当二硫化物结合,基于α 3 /5 conotoxinsfrom C 的 cDNA 序列。achatinus。Ac1.1a 和 Ac1.1b 由一仅仅氨基酸残余不同。他们分别地在堵住在 Xenopus laevisoocytes 表示的 recombinant 老鼠肌肉醋胆素受体上有类似的力量,与 36 nM 和 26 nM 的 IC_(50 ) 价值。为 Ac1.1b,开始的三 N 终端氨基酸的删除没改变它的活动,显示 N 终点不涉及和它的受体的相互作用。而且,我们的实验显示两毒素强烈在老鼠肌肉上比较喜欢α _1- δ子单元接口而不是α _1- γ结合部位烟碱的醋胆素受体。这些肽为结构的学习和烟碱的受体的功能提供另外的工具。 | Li LIU Geoffrey CHEW Edward HAWROT Chengwu CHI Chunguang WANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，6： | 5 |
| 15 | 直肠癌根治术中的盆腔自主神经保护:30年变迁显示文摘全直肠系膜切除(TME)理念及微创技术(如腹腔镜结直肠手术和机器人手术)的出现大大提高直肠癌的外科疗效。然而,术后排尿功能和性功能障碍率仍然较高,从而给患者造成巨大的痛苦,同时也会给手术医生带来困扰。新辅助和辅助放疗应用的增多也带来了更多的功能问题。在本文中,我们对盆腔神经解剖的目前认识进行了评价,将盆腔神经分为肠系膜下动脉根部、侧盆壁及泌尿生殖器官周围等区域,探讨了在这些区域如何进行手术操作。同时,我们也讨论了过去30年不同手术方式(包括开腹、腹腔镜和机器人)的功能状况。 | Min-Hoe Chew Yu-Ting Yeh Evan Lim Francis Seow-Choen | 2016 | Gastroenterology Report2016，4，3： | 5 |
| 16 | Psychological aspects of diabetes care: Effecting behavioral change in patients显示文摘Patients with diabetes mellitus(DM) need psychological support throughout their life span from the time of diagnosis. The psychological make-up of the patients with DM play a central role in self-management behaviors. Without patient's adherence to the effective therapies, there would be persistent sub-optimal contro of diseases, increase diabetes-related complications,causing deterioration in quality of life, resulting in increased healthcare utilization and burden on healthcare systems. However, provision of psychosocial support is generally inadequate due to its challenging nature of needs and demands on the healthcare systems. This review article examines patient's psychological aspects in general, elaborates in particular about emotion effects on health, and emotion in relation to other psychological domains such as cognition, self-regulation,self-efficacy and behavior. Some descriptions are also provided on willpower, resilience, illness perception and proactive coping in relating execution of new behaviors,coping with future-oriented thinking and influences of illness perception on health-related behaviors. These psychological aspects are further discussed in relationto DM and interventions for patients with DM. Equipped with the understanding of the pertinent nature of psychology in patients with DM; and knowing the links between the psychological disorders, inflammation and cardiovascular outcomes would hopefully encourages healthcare professionals in giving due attention to the psychological needs of patients with DM. | Boon-How Chew Sazlina Shariff-Ghazali Aaron Fernandez | 2014 | World Journal of Diabetes2014，5，6： | 5 |
| 17 | Antioxidant and antibacterial activity of different parts of Leucas aspera显示文摘Objective:To evaluate antioxidant,antimicrobial and cytotoxic activity of different parts(root, flower,leaf and stem)of Leucas aspera(L.aspera)(Labiatae).Methods:Different parts of L.aspera were extracted with 80%(v/v)methanol.The methanol extracts were subjected to antioxidant, antimicrobial and brine shrimp lethality assay.Results:All the extracts showed moderate to potent antioxidant activity,among which the root extract demonstrated the strongest antioxidant activity with the IC_(50)value of 6.552μg/mL.Methanol extract of root possessed antioxidant activity near the range of vitamin E and thus could be a potential rich source of natural antioxidant.In case of antimicrobial screening,crude extracts of root,flower,leaf and stem showed notable antibacterial activity against tested microorganisms.The root extract showed the highest mean zone of inhibition ranging from 9.0-11.0 mm against tested microorganisms,at a concentration of 100 mg/mL.In the brine shrimp lethality bioassay,it was evident that the methanol root extract did not show significant toxicity.The LC_(50)value for 12 h and 24 h observation was 2.890 mg/mL and 1.417 mg/mL,respectively.Conclusions:The present finding suggests that the methanol root extract of L.aspera could be developed as pharmaceutical products. | Ai Lan Chew Jeyanthi James Antony Jessica Sreenivasan Sasidharan | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，3： | 4 |
| 18 | Conventional laparoscopic versus single-incision laparoscopic right hemicolectomy: a case cohort comparison of short-term outcomes in 144 consecutive cases显示文摘 | Min-Hoe Chew Mei-Huan Chang Wah-Siew Tan Mark Te-Ching Wong Choong-Leong Tang | 2013 | Surgical Endoscopy2013，，2： | 4 |
| 19 | Naloxone attenuates ischemic brain injury in rats through suppressing the NIK/IKKα/NF-κB and neuronal apoptotic pathways显示文摘Although naloxone has been documented to exert neuroprotection in animal model of cerebral ischemia, the mechanism is not well understood. In this present study we investigated whether naloxone affected the mitochondrial apoptotic pathway in ischemic brain injury of rats. SD rats were subjected to a permanent middle cerebral artery occlusion surgery, and received naloxone (0.5, 1, 2 mg/kg, i.v.) immediately after ischemia. Neurological deficits were evaluated 24 h after ischemia using the McGraw Stroke Index, and then the rats were killed, and the brains were collected for further analyses. We show that naloxone treatment dose-dependently decreased the infarction volume and morphological injury, improved motor behavioral function, and markedly curtailed brain edema. Furthermore, naloxone administration significantly inhibited the nuclear translocation of NF-κB p65 and decreased the levels of nuclear NF-κB p65 in the ischemic penumbra. Naloxone administration also dose-dependently increased the NF-κB inhibitory protein (IκBα) levels and attenuated phosphorylated NIK and IKKα levels in the ischemic penumbra. In addition, naloxone administration dose-dependently increased Bcl-2 levels, decreased Bax levels, stabilized the mitochondrial transmembrane potential, and inhibited cytochrome c release and caspase 3 and caspase 9 activation. These results indicate that the neuroprotective effects of naloxone against ischemic brain injury involve the inhibition of NF-κB activation via the suppression of the NIK/IKKα/IκBα pathway and the obstruction of the mitochondrial apoptotic pathway in neurons. | Xuan Wang Zu-jun Sun Jun-lu Wu Wen-qiang Quan Wei-dong Xiao Helen Chew Cui-min Jiang Dong Li | 2019 | Acta Pharmacologica Sinica2019，40，2： | 4 |
| 20 | 建筑垃圾在公路路基填筑中的有效应用显示文摘社会经济飞速发展的时代背景为建筑行业提供了良好的发展机会,虽然建筑不断增多象征着国家综合实力提高,但是在建设过程中会产生很多建筑垃圾,如果不及时处理,就会对居民生活和周边环境造成不利影响。实践表明,将建筑垃圾用于公路路基填筑,可以有效缓解建筑垃圾破坏生态环境的现状。据此相关部门应该加强对建筑垃圾在公路路基填筑中应用策略的研究力度,旨在推动建筑行业更好、更快的发展。 | 尤忆 Chew Boon Cheong | 2021 | 工业建筑2021，51，10： | 3 |
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