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| 1 | Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one- compound peptide libraries显示文摘one-bead-one-compound (OBOC ) 组合的肽图书馆是一个强大的工具识别 ligand 和受体相互作用。这里,我们使用了 OBOC 图书馆技术识别对主要贝壳变应原 tropomyosin 的免疫球蛋白 E (IgE ) epitopes 特定的 mimotopes。有 8-12 氨基酸残余的 OBOC 肽图书馆为 tropomyosin 的 IgE mimotopes 与贝壳过敏症从病人与浆液样品被屏蔽。25 mimotopes 从屏蔽被识别,他们到 tropomyosin 特定的 IgE 的有约束力的反应被肽 ELISA 证实。这些 mimotopes 能基于顺序相同被划分成七簇,并且由聚类的 mimotopes 的 EpiSearch 印射的 epitope 被执行描绘并且证实 mimotopes 的有效性。五从六预言的 epitopes 被发现与 tropomyosin 的以前识别的 epitopes 重叠。为了推进,证实 mimotopes 的模仿潜力, BALB/c 老鼠被使免疫, mimotopes 结合了到锁眼恋栈者 hemocyanin 和 assayed 让他们的能力导致 tropomyosin 特定的抗体。那收到的 mimotope 免疫被发现有 tropomyosin 特定的免疫球蛋白 G 的提高的水平的 BALB/c 老鼠,然而并非收到了无关的 mimotope 的老鼠。这研究用整个 sera 开创 OBOC 图书馆的成功的申请屏蔽并且识别多重虾变应原 mimotopes 并且验证他们在 vitro 使用的模仿潜力,在 vivo,并且在 silico 方法。 | Nicki YH Leung Christine YY Wai Marco HK Ho Ruiwu Liu Kit S Lam Jin Jun Wang Shang An Shu Ka Hou Chu Patrick SC Leung | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
| 2 | Phacoemulsification versus combined phacotrabeculectomy in medically uncontrolled chrconic angle closure glaucoma with cataracts显示文摘 | Tham CC Kwong YY Leung DY | 2009 | Ophthalmology2009，，4： | 1 |
| 3 | Phacoemulsification vs- phacotrabeculectomy in chronic angle-closure glaucoma with cataract: complications 显示文摘 | Tham CC Kwong YY Leung DY | 2010 | Arch Ophthalmol2010，128，3： | 1 |
| 4 | Phacoemulsificationvs phacotabecutomy in chronic angle-closure glaucoma with cataract ;complications[corrected]显示文摘 | Tham CC Kwong YY Leung DY | | 0，，： | 1 |
| 5 | Incidence ofneurosensory deficits and recovery after lower third molarsurgery:a prospective clinical study of 4338 cases显示文摘 | Cheung LK Leung YY Chow LK | 2010 | IntJ Oral Maxillofac Surg2010，39，4： | 1 |
| 6 | Incidence of neurosensory deficits and recovery after lower third molar surgery: a prospective clinical study of 4338 cases 显示文摘 | Cheung LK Leung YY Chow LK | 2010 | Int J Oral Maxillofac Surg2010，39，4： | 1 |
| 7 | Safety of coronectomy versus excision of wis- dom teeth:a randomized controlled triM显示文摘 | Leung YY Cheung LK | 2009 | Oral Surg Oral Med O- ral Patbol Oral Radiol Endod2009，108，6： | 1 |
| 8 | Reconstruction of proximal femoral defects with a vascular-pedicled graft显示文摘 | Leung PC Chow YY | 1984 | J Bone Joint Surg Br1984，66，1： | 1 |
| 9 | Phacoemulsification versus combined phacotrabeculectomy in medically un- controlled chronic angle closure glaucoma with cataracts显示文摘 | Tham CC Kwong YY Leung DY | 2009 | Ophthalmology2009，116，4： | 1 |
| 10 | Safety of coronectomy versus excision of wisdom teeth:a randomized controlled trial显示文摘 | Leung YY Cheung LK | | 0，，06： | 1 |
| 11 | Phaeoemulsification vs phacotrabeculectomy in chronic angle - closure glaucoma with ca- laract : complications 显示文摘 | Tham CC Kwong YY Leung DY | 2010 | Arch Ophthalmol2010，128，3： | 1 |
| 12 | Phacoemulsification vs phacotrabeculectomy in chronic angle-closure glaucoma with cataract:complications 显示文摘 | Tham CC Kwong YY Leung DY | 2010 | Arch Ophthalmol2010，128，3： | 1 |
| 13 | Phaeoemulsification versus combined phacotrabeculectomy in medically uncon- trolled chronic angle closure glaucoma with cataracts显示文摘 | Tham CC Kwong YY Leung DY | 2009 | Oph- thalmology2009，116，4： | 1 |
| 14 | Phacoemulsification versus combined phacotrabeculectomy in medically uncontrolled chronic angle closure glaucoma with cataracts 显示文摘 | Tham CC Kwong YY Leung DY | 2009 | Ophthalmology2009，116，： | 1 |
| 15 | Secular changes in standing height,sitting height and sexual maturation of Chinese-the Hong Kong GrowthStudy, 1993显示文摘 | Leung SS Lau JT Xu YY | 1996 | AnnHum Biol1996，23，4： | 1 |
| 16 | Surgical ciliated cysts may mimic radicular cysts or residual cysts of maxilla: report of 3 cases显示文摘 | Leung YY Wong WY Cheung LK | 2012 | J Oral Maxillofac Surg2012，70，4： | 1 |
| 17 | Effects of phacoemulsification versus combined phacotrabeculectomy on drainage angle status in primary angle closure glaucoma (PACG)显示文摘 | Tham CC Leung DY Kwong YY Li FC LaiJS Lam DS | 2010 | J Glaucoma2010，19，2： | 1 |
| 18 | Urine protein-to-creatinine ratio in an untimed urine collection is a reliable measure of proteinuria in lupus nephritis显示文摘 | Leung YY Szeto CC Tam LS | | 0，，： | 1 |
| 19 | The outcome of 48 eyes with indirect traumatic optic neuropathy and periorbital facial bone fracture显示文摘 | Leung DY Kwong YY Lam DS | 2006 | J Trauma2006，60，3： | 1 |
| 20 | Phacoemulsification vs phacotrabeculectomy in chronic angle-closure glaucoma with cataract:complications显示文摘 | Tham CC Kwong YY Leung DY | 2010 | Arch Ophthalmol2010，128，： | 1 |
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